ENDOTHELIALIZATION

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Tailored endothelialization enabled by engineered endothelial cell vesicles accelerates remodeling of small-diameter vascular grafts
《Bioactive Materials》2024年第11期127-136,共10页Zihao Wang Mengxue Zhou Mengyu Li Jinyu Li Shengmin Zhang Jianglin Wang 
National Key Research and Development Program of China(2022YFA1105100);National Natural Science Foundation of China(32301102;32171323);Fundamental Research Funds for the Central Universities(YCJJ20230215);Science,Technology and Innovation Commission of Shenzhen Municipality(KCXFZ20211020164544008);Sanming Project of Medicine in Shenzhen(SZSM201812055).
Current gold standard for the replacement of small-diameter blood vessel(ID<4 mm)is still to utilize the autologous vessels of patients due to the limitations of small-diameter vascular grafts(SDVG)on weak endothelial...
关键词：Small-diameter vascular grafts Tailored endothelialization Endothelial cell vesicles Click chemistry Vascular remodeling 
Bilayer vascular grafts with on-demand NO and H_(2)S release capabilities
《Bioactive Materials》2024年第1期38-52,共15页Pengfei Li Fubang Liang Lijuan Wang Dawei Jin Yushuang Shang Xu Liu Yanjun Pan Jiang Yuan Jian Shen Meng Yin 
supported by the National Natural Science Fund of China(81873923);Jiangsu Higher Education Institutions(19KJA310001 and PAPD);Jiangsu Collaborative Innovation Center of Biomedical Functional Materials.
Nitric oxide(NO)and hydrogen sulfide(H_(2)S)gasotransmitters exhibit potential therapeutic effects in the car-diovascular system.Herein,biomimicking multilayer structures of biological blood vessels,bilayer smalldiame...
关键词：Small-diameter vascular grafts Nitric oxide Hydrogen sulfide KERATIN ENDOTHELIALIZATION 
Functionalization of in vivo tissue-engineered living biotubes enhance patency and endothelization without the requirement of systemic anticoagulant administration被引量：2
《Bioactive Materials》2023年第8期292-305,共14页Hongyu Yan Quhan Cheng Jianghua Si Songdi Wang Ye Wan Xin Kong Ting Wang Wenting Zheng Muhammad Rafique Xiaofeng Li Ju He Adam C.Midgley Yi Zhu Kai Wang 
supported by the National Natural Science Foundation of China(NSFC)projects 81921004(D.K.),82127808(D.K.),32222043(K.W.),82250610231(A.C.M.);National Key R&D Program of China 2022YFA1105102(K.W.);Tianjin Natural Science Foundation 20JCYBJC01150(K.W.);Tianjin Natural Science Foundation 18JCZDJC37600(K.W.);NCC Fund NCC2020PY18(K.W.);Tianjin"Project+Team"Key Training Foundation XC202035(K.W.).
Vascular regeneration and patency maintenance,without anticoagulant administration,represent key developmental trends to enhance small-diameter vascular grafts(SDVG)performance.In vivo engineered autologous biotubes h...
关键词：In vivo tissue-engineering Biotube Living tissue modification ANTICOAGULATION Rapid endothelialization 
Fucoidan and topography modification improved in situ endothelialization on acellular synthetic vascular grafts被引量：3
《Bioactive Materials》2023年第4期535-550,共16页Yuan Yao Aung Moe Zaw Deirdre E.J.Anderson YeJin Jeong Joshua Kunihiro Monica T.Hinds Evelyn K.F.Yim 
This work was supported by the National Institutes of Health grants[NIH R01HL130274 and R01HL144113];NSERC-CREATE Training in Global Biomedical Technology Research and Innovation at the University of Waterloo[CREATE-509950-2018];Canada Foundation for Innovation(CFI35573);NSERC Research Tools and Instruments Fund(RTI-2018-00220);the Oregon National Primate Research Center NIH grant award[P51OD011092].
Thrombogenesis remains the primary failure of synthetic vascular grafts.Endothelial coverage is crucial to provide an antithrombogenic surface.However,most synthetic materials do not support cell adhesion,and transana...
关键词：Blood-contacting devices Small diameter vascular graft ENDOTHELIALIZATION TOPOGRAPHY FUCOIDAN 
A TEMPOL and rapamycin loaded nanofiber-covered stent favors endothelialization and mitigates neointimal hyperplasia and local inflammation被引量：4
《Bioactive Materials》2023年第1期666-677,共12页Rui Wang Jian Lu Jiasheng Yin Han Chen Hongmei Liu Fei Xu Tongtong Zang Rende Xu Chenguang Li Yizhe Wu Qilin Wu Xiang Fei Meifang Zhu Li Shen Junbo Ge 
supported by the National Natural Science Foundation of China(No.82170342);the Shanghai Engineering Research Center of Interventional Medicine(No.19DZ2250300);the National Key R&D Program of China(No.2021YFA1201300 and No.2020YFC1316703);the Chinese Academy of Medical Sciences(2019-I2M-5-060,2020-JKCS-0154020);the Shanghai Shenkang Hospital Development Center(SHDC2020CR3023B).
An increased level of reactive oxygen species(ROS)plays a major role in endothelial dysfunction and vascular smooth muscle cell(VSMC)proliferation during in-stent thrombosis and restenosis after coronary artery stenti...
关键词：Electrospun nanofiber membrane In-stent restenosis RE-ENDOTHELIALIZATION Reactive oxygen species 
Advances in coatings on magnesium alloys for cardiovascular stents-A review被引量：17
《Bioactive Materials》2021年第12期4729-4757,共29页Zhao-Qi Zhang Yong-Xin Yang Jing-An Li Rong-Chang Zeng Shao-Kang Guan 
The authors are grateful for the financial support of the National Natural Science Foundation of China(No.U1804251);the National Key Research and Development Program of China(No.2017YFB0702504 and 2018YFC1106703).
Magnesium(Mg)and its alloys,as potential biodegradable materials,have drawn wide attention in the cardiovascular stent field because of their appropriate mechanical properties and biocompatibility.Nevertheless,the occ...
关键词：Magnesium alloy Cardiovascular stent Surface modification Rapid endothelialization Functional properties 
Covalent functionalization of decellularized tissues accelerates endothelialization被引量：1
《Bioactive Materials》2021年第11期3851-3864,共14页Eleonora Dal Sasso Annj Zamuner Andrea Filippi Filippo Romanato Tiziana Palmosi Luca Vedovelli Dario Gregori Jose Luís Gòmez Ribelles Teresa Russo Antonio Gloria Laura Iop Gino Gerosa Monica Dettin 
Padua Heart Program(CA.RI.PA.RO.Foundation);LIFELAB Program,Consorzio per la Ricerca Sanitaria-CORIS,Veneto Region,Via Giustiniani,2-Padova;JLGR acknowledges financial support from the Spanish State Research Agency(AEI)through the PID2019-106099RB-C41/AEI/10.13039/501100011033 project;CIBER-BBN is an initiative funded by the VI National R&D&I Plan 2008-2011,Iniciativa Ingenio 2010,Consolider Program.CIBER Actions are financed by the Instituto de Salud CarlosⅢwith assistance from the European Regional Development Fund.
In the field of tissue regeneration,the lack of a stable endothelial lining may affect the hemocompatibility of both synthetic and biological replacements.These drawbacks might be prevented by specific biomaterial fun...
关键词：Decellularized pericardium Decellularized aorta Covalent functionalization ENDOTHELIALIZATION REDV Mechanical analysis 
Selection of different endothelialization modes and different seed cells for tissue-engineered vascular graft被引量：5
《Bioactive Materials》2021年第8期2557-2568,共12页Qingjin Cai Wanshan Liao Fangchao Xue Xiaochen Wang Weiming Zhou Yanzhao Li Wen Zeng 
supported by The National Science Fund for Outstanding Young Scholars(No:31822021);The Key Research and Development Plan Young Scientists Program(No:2017YFA0106000);The National Key Research and Development Plan(No:2016YFC1101100);National Science Foundation of China(No:31771057).
Tissue-engineered vascular grafts(TEVGs)have enormous potential for vascular replacement therapy.However,thrombosis and intimal hyperplasia are important problems associated with TEVGs especially small diameter TEVGs(...
关键词：Tissue-engineered vascular grafts scaffold materials seed cells vascular endothelialization endothelial heterogeneity 
Coaxial-printed small-diameter polyelectrolyte-based tubes with an electrostatic self-assembly of heparin and YIGSR peptide for antithrombogenicity and endothelialization被引量：7
《Bioactive Materials》2021年第6期1628-1638,共11页Zhiwen Zeng Chengshen Hu Qingfei Liang Lan Tang Delin Cheng Changshun Ruan 
The authors gratefully acknowledge the support for this work from the National Key research and Development Program(Grant No.2018YFA0703100);the National Natural Science Foundation of China(Grant Nos.82072082,31900959);the Youth Innovation Promotion Association of CAS(Grant No.2019350);the Guangdong Natural Science Foundation(Grant No.2019A1515011277);the Shenzhen Fundamental Research Foundation(Grant No.JCYJ20180507182237428).
Low patency ratio of small-diameter vascular grafts remains a major challenge due to the occurrence of thrombosis formation and intimal hyperplasia after transplantation.Although developing the functional coating with...
关键词：Coaxial extrusion printing Electrostatic self-assembly Sequential release ANTITHROMBOGENICITY ENDOTHELIALIZATION 
Challenges and strategies for in situ endothelialization and long-term lumen patency of vascular grafts被引量：14
《Bioactive Materials》2021年第6期1791-1809,共19页Yu Zhuang Chenglong Zhang Mengjia Cheng Jinyang Huang Qingcheng Liu Guangyin Yuan Kaili Lin Hongbo Yu 
This work was funded by the National Natural Science Foundation of China(82072396,81871490,81571022);Shanghai Collaborative Innovation Center for Translational Medicine(TM202010);Program of Shanghai Academic/Technology Research Leader(19XD1434500);Double Hundred Plan(20191819);the Research Fund of Medicine and Engineering of Shanghai Jiao Tong University(YG2017MS06).
Vascular diseases are the most prevalent cause of ischemic necrosis of tissue and organ,which even result in dysfunction and death.Vascular regeneration or artificial vascular graft,as the conventional treatment modal...
关键词：Vascular graft In situ endothelialization THROMBOGENESIS Intimal hyperplasia IMMUNOMODULATION 
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