This editorial discusses Pellegrino and Gravina's essay.Crohn’s disease(CD)is a complex and multifactorial disease that is influenced by a combination of genetic and environmental factors.While genetic factors play a...
Supported by the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(No.ZYYCXTD-C-202006);the Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences(No.CI2021A00601 and CI2021B017-09)。
Objective: To investigate the inhibitory effect of Tanreqing Injection(TRQ) on the activation of nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3(NLRP3) inflammasome in macrophages inf...
This article provides commentary on the article by Zhang et al.In this original research,Zhang et al investigated the therapeutic potential of teneligliptin for diabetic cardiomyopathy(DCM),which was mediated by targe...
supported by the Major Program of the National Natural Science Foundation of China (No. 82192915);the National Key Research and Development Program (No. 2018YFC1704500)
Objective: Chronic atrophic gastritis(CAG) is a complex and burdensome disease. However, side effects and compliance issues cannot be ignored due to the long treatment cycle. Numerous studies have confirmed the effect...
Supported by National Natural Science Foundation of China,No.82104747 and No.82305133;Basic and Applied Basic Research Foundation of Guangdong Province,China,No.2020A1515110947;General Project of Shenzhen Science and Technology Innovation Commission,No.JCYJ20230807094659030,No.JCYJ20230807094805012,No.JCYJ20210324111602007,and No.JCYJ20220531091815034;the Scientific Research Project of Guangdong Provincial Bureau of Traditional Chinese Medicine,No.20221349.
BACKGROUND Gastric intestinal metaplasia(IM)is a precancerous lesion that is associated with an elevated risk of gastric carcinogenesis.Weiwei Decoction(WWD)is a promising traditional Chinese herbal formula widely emp...
supported by grants from the Swiss National Science Foundation (310030_204165 and 310030B_182833);by funding from the University of Zurich.
Plant defense responses to pathogens are induced after direct or indirect perception of effector proteins or their activity on host proteins.In fungal–plant interactions,relatively little is known about whether,in ad...
funding support from the National Natural Science Foundation of China(No.81872749);Shenzhen Science and Technology Innovation Commission(Nos.20200815000631001 and JCYJ20200109120414564);Peking University。
Adenine is an essential building block of genetic material and a range of coenzymes.Chemical probes containing an adenine moiety have been used in kinase profiling studies in cell lysates.Here we report that adenine-d...
supported by the National Research Foundation of Korea(NRF)funded by the Korean Ministry of Education(Global PhD Fellowship Program Project 500–20190213);by the Ministry of Sciences and ICT(Projects 2018R1A5A1023599,2020R1A2C1101419).
Bacterial wilt disease caused by several Ralstonia species is one of the most destructive diseases in Solanaceae crops.Only a few functional resistance genes against bacterial wilt have been cloned to date.Here,we sho...
Supported by the National Key Research and Development Program(Grant 2018YFC1705403):Clinical Effect Evaluation of Chinese Medicine on Moderately Active Ulcerative Colitis;Natural Science Foundation of Tianjin(Grant18JCYBJC26000):Study on the Mechanism of Qingchi San Treating Ulcerative Colitis By Regulating Gut Microflora;Scientific Research Program of Tianjin Education Commission(Grant 2017KJ155):based onγδT-NLRP3 Inflammasome-Caspase Pathway;Qingchi San Regulates Gut Microflora to Treat UC。
OBJECTIVE:To investigate the efficacy of Qingchi San(青赤散,QCS),a preparation of Traditional Chinese Medicine,on ulcerative colitis(UC)in mice by inhibiting the nuclearfactor-kappa B(NF-κB)signaling pathway and nucl...
supported by the National Natural Science Foundation of China(No.81370282).
Objective The ATP responsive P2 purinergic receptors can be subdivided into metabotropic P2X family and ionotropic P2Y family.Among these,P2X3 is a type of P2X receptor which is specifically expressed on nerves,especi...