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Progress of research in the application of ultrasound technology for the treatment of Alzheimer’s disease: 《Neural Regeneration Research》2025年第10期2823-2837,共15页Qiuquan Cai Lianghui Meng Meina Quan Ling Wang Jing Ren Chenguang Zheng Jiajia Yang Dong Ming; supported by the National Natural Science Foundation of China,Nos.82371886(to JY),81925020(to DM),82202797(to LW),and 82271218(to CZ).; Alzheimer’s disease is a common neurodegenerative disorder defined by decreased reasoning abilities,memory loss,and cognitive deterioration.The presence of the blood-brain barrier presents a major obstacle to the dev...; 关键词：Alzheimer’s disease blood-brain barrier DRUGS magnetic resonance imaging-guided focused ultrasound MICROBUBBLES scanning ultrasound ULTRASOUND ultrasound stimulation

Potential role and therapeutic implications of glutathione peroxidase 4 in the treatment of Alzheimer's disease: 《Neural Regeneration Research》2025年第3期613-631,共19页Yanxin Shen Guimei Zhang Chunxiao Wei Panpan Zhao Yongchun Wang Mingxi Li Li Sun; supported by the National Natural Science Foundation of China,No.82071442 (to LS);a grant from the Jilin Provincial Department of Finance,No.JLSWSRCZX2021-004 (to LS)。; Alzheimer's disease is an age-related neurodegenerative disorder with a complex and incompletely understood pathogenesis. Despite extensive research, a cure for Alzheimer's disease has not yet been found. Oxidative st...; 关键词：apoptosis ferroptosis inflammation lipid peroxidation natural plant products neurodegenerative disorder NEUROPROTECTION oxidative stress small-molecule drugs

Sexual dimorphism of G protein-coupled receptor signaling in the brain: 《Neural Regeneration Research》2024年第8期1635-1636,共2页Sara Aljoudi Hamdan Hamdan Khaled S.Abd-Elrahman; supported by a New Investigator grant fram the Alzheimer’s Society of Canada and Alzheimer Disease Research Grant from Djavad Mowafaghian Centre for Brain Health(to KSAE)。; G protein-coupled receptors(GPCRs)represent the most substantial family of membrane receptors that are targeted by U.S.Food and Drug Administration-approved drugs.Much of the preclinical research to understand the pha...; 关键词：DRUGS CLINICAL TARGETED

Use of induced pluripotent stem cell-derived brain cells,organoids,assembloids,and blood-brain barrier models in understanding alcohol and anesthetic-induced brain injuries:an emerging perspective: 《Neural Regeneration Research》2024年第5期953-954,共2页Xiaowen Bai; supported by grants R01 GM112696 and 1R35GM148177 from the National Institutes of Health(to XB);Advancing a Healthier Wisconsin(to XB);Medical College of Wisconsin-Neuroscience Research Center-Alzheimer’s Award(to XB).; Neurological disorders,including developmental disorders,Alzheimer’s disease(AD),and psychiatric conditions,have significant social and economic impacts globally.Despite extensive research into the underlying mechani...; 关键词：INJURIES protective DRUGS

Multiple sclerosis drug repurposing for neuroregeneration: 《Neural Regeneration Research》2024年第3期507-508,共2页Peter Göttle Michael Dietrich Patrick Küry; financially supported by Novartis (to PK); Multiple sclerosis(MS)is an autoimmune disorder of the central nervous system(CNS)and is primarily characterized by immune cell infiltration leading to relapses followed by remission phases and a disease course turnin...; 关键词：DRUGS IMPAIRED IRREVERSIBLE

Historic recurrences in medicinal chemistry:nature-inspired structures as a new opportunity for novel multi-target anti-Alzheimer's drugs被引量：1: 《Neural Regeneration Research》2023年第12期2671-2672,共2页Luca Piemontese; Alzheimer 's disease(AD) is an alarming noncommunicable, multi-factorial, and non-treatable disease. Its underlying neurodegenerative events have not yet been fully explained and its early diagnosis is very difficult....; 关键词：ALZHEIMER DRUGS diagnosis

Emerging non-invasive therapeutic approaches targeting hypocholinergic neural systems in Parkinson's disease: 《Neural Regeneration Research》2023年第4期809-810,共2页Nicolaas I.Bohnen Alison J.Yarnall; supported by the National Institute of Health,No.P50 NS123067;The Farmer Family Foundation;supported by the NIHR Newcastle Biomedical Research Centre(BRC);The NIHR BRC is a partnership between Newcastle Hospitals NHS Foundation Trust and Newcastle University;funded by the National Institute for Health and Care Research(NIHR)。; Cholinergic system associated DOPA-refractory motor and cognitive symptoms-a need for novel therapeutic approaches:Accumulating evidence points to significant motor and non-motor morbidities associated with hypocholin...; 关键词：CHOLINERGIC THERAPEUTIC DRUGS

Nilotinib:from animal-based studies to clinical investigation in Alzheimer's disease patients被引量：1: 《Neural Regeneration Research》2023年第4期803-804,共2页Annalisa Nobili Marcello D’Amelio Maria Teresa Viscomi; supported by Linea D.1.2021 UniversitàCattolica del S.Cuore(to MTV);by the Italian Ministry of Health(IT)[Research Grant:RF-2018-12365527,to MDA and MTV];supported by the American Alzheimer’s Association[AARG-21-851219];by Fondazione Roma(Rome,Italy)。; Since their first description in the brains of patients suffering from Alzheimer ’s disease(AD), more than 100 years ago, extracellular amyloid-β(Aβ) plaques and intracellular neurofibrillary tangles have been the ...; 关键词：ALZHEIMER AΒ DRUGS

Molecular approaches for spinal cord injury treatment被引量：11: 《Neural Regeneration Research》2023年第1期23-30,共8页Fernanda Martins de Almeida Suelen Adriani Marques Anne Caroline Rodrigues dos Santos Caio Andrade Prins Fellipe Soares dos Santos Cardoso Luiza dos Santos Heringer Henrique Rocha Mendonça Ana Maria Blanco Martinez; supported by CAPES;Faperj;CNPq;‘‘National Institute of Science and Technology for Regenerative Medicine”, CNPq, Brazil(to AMBM); Injuries to the spinal cord result in permanent disabilities that limit daily life activities.The main reasons for these poor outcomes are the limited regenerative capacity of central neurons and the inhibitory milieu...; 关键词：axonal regeneration DRUGS ENZYMES growth factors molecular therapy neurotrophic factors PURINES spinal cord injury

How physical and motor training affect cognitive performance: lessons from an inflammatory molecule: 《Neural Regeneration Research》2022年第12期2689-2690,共2页Margherita Maffei Marco Mainardi; Our phenotype includes not only physical features,but also behavioral outputs such as motor schemes and learned skills,and is the result of a complex interaction between genetic background and environment.In fact,a go...; 关键词：instance DRUGS LESSON

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