PURINES

作品数：11被引量：44H指数：3
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Molecular approaches for spinal cord injury treatment被引量：11
《Neural Regeneration Research》2023年第1期23-30,共8页Fernanda Martins de Almeida Suelen Adriani Marques Anne Caroline Rodrigues dos Santos Caio Andrade Prins Fellipe Soares dos Santos Cardoso Luiza dos Santos Heringer Henrique Rocha Mendonça Ana Maria Blanco Martinez 
supported by CAPES;Faperj;CNPq;‘‘National Institute of Science and Technology for Regenerative Medicine”, CNPq, Brazil(to AMBM)
Injuries to the spinal cord result in permanent disabilities that limit daily life activities.The main reasons for these poor outcomes are the limited regenerative capacity of central neurons and the inhibitory milieu...
关键词：axonal regeneration DRUGS ENZYMES growth factors molecular therapy neurotrophic factors PURINES spinal cord injury 
Visible light induced oxidative coupling of purines with arenes
《Chinese Chemical Letters》2023年第1期313-316,共4页Lamei Liao Dongen Lin Gary Histand 
supported by Basic and Applied Basic Research Foundation of Guangdong Province in China(No.2021A1515012349)。
The photocatalyzed synthesis of 9-arylpurines has been developed using 9H-purines and non-activated arenes.This method is highly atom economical using an acridinium photocatalyst induced by visible light under air atm...
关键词：Visible light PHOTOCATALYSIS Purine derivatives C–N bond formation Additive free 
From purines to purinergic signalling:molecular functions and human diseases被引量：17
《Signal Transduction and Targeted Therapy》2021年第5期1463-1482,共20页Zhao Huang Na Xie Peter Illes Francesco Di Virgilio Henning Ulrich Alexey Semyanov Alexei Verkhratsky Beata Sperlagh Shu-Guang Yu Canhua Huang Yong Tang 
This article is dedicated to the memory of recently deceased Professor Geoffrey Burnstock.This work was supported by grants from National Key R&D Programme of China(2019YFC1709101,2020YFA0509400,2020YFC2002705);the National Natural Science Foundation of China(81821002,81790251,81373735,81972665);Guangdong Basic and Applied Basic Research Foundation(2019B030302012);the Project First-Class Disciplines Development of Chengdu University of Traditional Chinese Medicine(CZYHW1901);Sao Paulo Research Foundation(FAPESP 2018/07366-4);NSFC and RFBR(project number 21-54-53018,82111530059);MDT programme of State Administration of Traditional Chinese Medicine;Science and Technology Programme of Sichuan Province,China(2019YFH0108,2021JDGD0037).
Purines and their derivatives,most notably adenosine and ATP,are the key molecules controlling intracellular energy homoeostasis and nucleotide synthesis.Besides,these purines support,as chemical messengers,purinergic...
关键词：METABOLISM DISEASES URINE 
Purines:From Diagnostic Biomarkers to Therapeutic Agents in Brain Injury被引量：2
《Neuroscience Bulletin》2020年第11期1315-1326,共12页Bruno G.Frenguelli Nicholas Dale 
The purines constitute a family of inter-related compounds that serve a broad range of important intracellular and extracellular biological functions.In particular,adenosine triphosphate(ATP)and its metabolite and pre...
关键词：PURINES ADENOSINE ATP Biomarker Stroke Cerebral ischemia Traumatic brain injury ADENINE D-RIBOSE 
Purines Change at Acupoints along the Pericardium Meridian in Healthy and Myocardial Ischemic Rats被引量：3
《Chinese Journal of Integrative Medicine》2019年第4期285-291,共7页ZHOU Yu-mei ZHUANG Yi CAI Ding-jun LV Pei-ran ZHOU Jie WAN Min REN Yu-lan LIANG Fan-rong 
Supported by National Natural Science Foundation of China(No.81590951,81373559,81373561 and 81573885);the State Key Program for Basic Research of China(No.2012CB518501);the Project of the Second Clinical Medical College of Nanjing University of Chinese Medicine(No.RLZZ201605)
Objective: To quantify the purine concentrations of the acupoints along the pericardium and nonpericardium meridians under healthy and myocardial ischemia conditions to investigate the relationship between acupoint pu...
关键词：acupoint MYOCARDIAL ischemia PERICARDIUM meridian PURINE adenosine MICRODIALYSIS high-performance liquid chromatography 
N-9 Alkylation of purines via light-promoted and metal-free radical relay被引量：1
《Chinese Chemical Letters》2018年第1期61-64,共4页Runze Mao Lifeng Sun Yong-Shi Wang Min-Min Zhou De-Cai Xiong Qin Li Xin-Shan Ye 
financially supported by the National Natural Science Foundation of China(Nos. 21232002. 21572012);Beijing Natural Science Foundation (No. 7152085)
A metal-free and light-promoted approach to the synthesis of N-9 alkylated purine nucleoside derivatives, via a CF3 radical triggered radical relay pathway, has been developed. Purine nucleoside derivatives were prepa...
关键词：PhotochemistryAlkylation of purinesRegioselectivityMetal fleeCF3 radical 
Synthesis of C8-alkyl-substituted purine analogues by direct alkylation of 8-H purines with tetrahydrofuran catalyzed by CoCl2·6H2O被引量：1
《Chinese Chemical Letters》2017年第1期105-108,共4页Hong-Ying Niu Ling-Yun Su Shi-Xia Bai Jian-Ping Li Xi-Lan Feng Hai-Ming Guo 
the National Natural Science Foundation of China (No. 21202039);the Program for Science & Technology Innovation Talents in Universities of Henan Province (No. 13HASTIT013);the Foundation for University Young Key Teacher by Henan Province of China (No. 2011GGJS132)
C8-Alkyl-substituted purine analogues were synthesized through direct alkylation of 8-H purine with tetrahydrofuran in the presence of Co catalyst in one step. The reactions gave a series of novel C8-oxygen heterocycl...
关键词：PURINE C-H activation ALKYLATION TETRAHYDROFURAN Co-catalyzed 
Development and Validation of a Single HPLC Method for Analysis of Purines in Fish Oil Supplements
《Food and Nutrition Sciences》2013年第12期1255-1259,共5页Liton Roy Chad C. Harrell Alan S. Ryan Thorsteinn Thorsteinsson Frederick D. Sancilio 
Gout is one of the most common forms of inflammatory arthritis, affecting over 8 million adults in the US. Individuals with gout are advised to avoid the habitual intake of purine-rich foods such as meats, seafood, pu...
关键词：PURINES CHROMATOGRAPHY GOUT Uric Acid Omega-3 FATTY ACIDS 
Common misconceptions about 5-aminosalicylates and thiopurines in inflammatory bowel disease被引量：9
《World Journal of Gastroenterology》2011年第30期3467-3478,共12页Javier P Gisbert María Chaparro Fernando Gomollón 
Misconceptions are common in the care of patients with inflammatory bowel disease(IBD).In this paper,we state the most commonly found misconceptions in clinical practice and deal with the use of 5-aminosalicylates and...
关键词：Crohn＇ s disease Ulcerative colitis Inflam-matory bowel disease AMINOSALICYLATES STEROIDS AZATHIOPRINE MERCAPTOPURINE Misconceptions 
Tetra-n-butylammonium Hydroxide:an Efficient Catalyst for N-Alkylation of Pyrimidines and Purines
《Chemical Research in Chinese Universities》2006年第4期451-454,共4页ZHANG Zhi-li~ , ZHOU Shou-xin, WANG Xiao-wei, WANG Hong-tao, CHEN Yan-li and LIU Jun-yi Department of Chemical Biology, School of Pharmaceutical Sciences State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, P. R. China 
Supported by the National Natural Science Foundation of China(No. 20172007) and the"985"Programs, Ministry of Educa-tion of China
An efficient procedure for N-alkylation of pyrimidines and purines in the presence of tetra-n-butylammonium hydroxide（TBAH） is described. The method is very practical and the alkylation can occur at room temperature...
关键词：Tetra-n-butylammonium hydroxide N-ALKYLATION Purine Pyrimidine 
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