POLYPHARMACOLOGY

作品数：13被引量：12H指数：2
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相关领域：医药卫生更多>>
相关机构：济宁市第一人民医院更多>>
相关期刊：《World Journal of Cardiology》《Acta Pharmacologica Sinica》《Frigid Zone Medicine》《Computational Molecular Bioscience》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划SA-SIBS优秀人才奖励基金更多>>
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Piecing together aminergic polypharmacology
《Cell Research》2024年第9期599-600,共2页Blake A.Fordyce Bryan L.Roth 
Neuropsychiatric medications are often designed to have affinity for multiple ligand-binding sites across different receptor types to increase therapeutic efficacy. In a recent paper in Cell, Chen and colleagues imple...
关键词：MEDICATION efficacy. THERAPEUTIC 
The big data challenge-and how polypharmacology supports the translation from pre-clinical research into clinical use against neurodegenerative diseases and beyond
《Neural Regeneration Research》2024年第8期1647-1648,共2页Sven Marcel Stefan Muhammad Rafehi 
supported by the Walter Benjamin and Research Grant Programs of the German Research Foundation(Deutsche Forschungsgemeinschaft,DFG,Germany,#446812474,#504079349[PANABC])(to SMS),the DFG(#437446827);the Research Program of the University Medical Center Gottingen(to MR)。
Introductory comments:The identification and validation of disease-modifying proteins are fundamental aspects in drug development.However,the m ultifactority of n eurodegen era tive diseases poses a real challenge for...
关键词：TRANSLATION BEYOND LIKELY 
Pharmacologically significant constituents collectively responsible for anti-sepsis action of XueBiJing,a Chinese herb-based intravenous formulation被引量：4
《Acta Pharmacologica Sinica》2024年第5期1077-1092,共16页Chen Cheng Chao Ren Mu-zi Li Yi-hui Liu Ren-qi Yao Yang Yu Xuan Yu Jian-li Wang Li-xue Wang Yu-chun Leng Hui Zhang Fei-fei Du Ning Dong Feng-qing Wang Yao Wu Fang Xu Xiao-mei Zhu Gui-ping Zhang Kai Dong Si Liu Xiao-qing Yao Chuan Li Yong-ming Yao 
funded by National Natural Science Foundation of China(82192912,82074176,81801935,and 82272187);Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTD-C-202009);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA12050306).
Sepsis,a life-threatening health issue,lacks effective medicine targeting the septic response.In China,treatment combining the intravenous herbal medicine XueBiJing with conventional procedures reduces the 28-day mort...
关键词：Traditional Chinese medicine XUEBIJING SEPSIS mortality pharmacokinetic compatibility POLYPHARMACOLOGY 
Effects of site-directed mutagenesis of GLP-1 and glucagon receptors on signal transduction activated by dual and triple agonists
《Acta Pharmacologica Sinica》2023年第2期421-433,共13页Sanaz Darbalaei Ru-lue Chang Qing-tong Zhou Yan Chen An-tao Dai Ming-wei Wang De-hua Yang 
supported by National Natural Science Foundation of China 81872915(MWI),82073904(MW),82121005(DY),81973373(DY),21704064(QZ);National Science&Technology Major Project of China-Key New Drug Creation and Manufacturing Program 2018ZX09735-001(MW),2018ZX09711002-002-005(DY);National Science&Technology Major Project of China-Innovation 2030 for Brain Science and Brain-Inspired Technology 2021ZD0203400(QZ);the National Key Basic Research Program of China 2018YFA0507000(MW);Novo Nordisk-CAS Research Fund grant NNCAS-2017-1-CC(DY)and SA-SIBS Scholarship Program(IDY).
The paradigm of one drug against multiple targets,known as unimolecular polypharmacology,offers the potential to improve efficacy while overcoming some adverse events associated with the treatment.This approach is bes...
关键词：glucagon-like peptide-1 receptor glucagon receptor dual and triple agonist cAMP PERK1/2 unimolecular polypharmacology 
Kinome-wide polypharmacology profiling of small molecules by multi-task graph isomorphism network approach被引量：1
《Acta Pharmaceutica Sinica B》2023年第1期54-67,共14页Lingjie Bao Zhe Wang Zhenxing Wu Hao Luo Jiahui Yu Yu Kang Dongsheng Cao Tingjun Hou 
financially supported by National Key Research and Development Program of China(2021YFF1201400);National Natural Science Foundation of China(21575128,81773632,22173118);Natural Science Foundation of Zhejiang Province(LZ19H300001,China);Science and Technology Innovation Program of Hunan Province(2021RC4011,China)。
Prediction of the interactions between small molecules and their targets play important roles in various applications of drug development,such as lead discovery,drug repurposing and elucidation of potential drug side ...
关键词：Kinome-wide polypharmacology Machine learning KINASES Graph neural networks Artificial intelligence 
Antidiabetic agents:Do they hit the right targets?
《Frigid Zone Medicine》2022年第4期225-243,共19页Yongting Zhao Xiaofang Zhang Haihai Liang Lihong Wang 
supported by the National Natural Science Foundation of China(NSFC)(No.81770809).
Diabetes mellitus(DM)is a progressive metabolic disease characterized by chronic hyperglycemia and caused by different degree of pancreatic islet dysfunction and/or insulin resistance(IR).Long course DM can lead to a ...
关键词：diabetes mellitus type 2 diabetes mellitus anti-diabetic drugs therapeutic target glycemic control insulin resistance deficient insulin secretion diabetic complications POLYPHARMACOLOGY 
Molecular Modeling of Potential Dual Inhibitors of HIV Reverse Transcriptase and Integrase
《Computational Molecular Bioscience》2018年第1期1-41,共41页Alberto Cabrera Leonor Huerta Hernández Daniel Chávez José L. Medina-Franco 
With the goal of suggesting dual inhibitors of HIV reverse transcriptase (RT) and integrase (IN), herein we report the molecular docking of an initial set of 556 compounds related to the pyridinone class. Docking with...
关键词：AIDS ANTIVIRAL COMPUTER-AIDED DRUG Design DOCKING POLYPHARMACOLOGY 
Docking-based inverse virtual screening： methods, applications, and challenges被引量：5
《Biophysics Reports》2018年第1期1-16,共16页Xianjin Xu Marshal Huang Xiaoqin Zou 
Identifying potential protein targets for a small-compound ligand query is crucial to the process of drug development. However, there are tens of thousands of proteins in human alone, and it is almost impossible to sc...
关键词：Inverse virtual screening Target fishing POLYPHARMACOLOGY Side effects Drug repositioning Moleculardocking 
Exploiting kinase polypharmacology for nerve regeneration
《Neural Regeneration Research》2016年第1期71-72,共2页Hassan Al-Ali John L.Bixby Vance P.Lemmon 
The human central nervous system（CNS）has a markedly poor capacity for regenerating its axons following injury.This appears to be due to two main causes：1）a developmentally regulated decline in regenerative capacit...
关键词：regeneration alterations mature markedly constitute regenerative barriers phenotypic similarity inhibit 
Systems psychopharmacology:A network approach to developing novel therapies被引量：1
《World Journal of Psychiatry》2016年第1期66-83,共18页Peter J Gebicke-Haerter 
support of the Faculty of Medicine,University of Chile
The multifactorial origin of most chronic disorders of the brain, including schizophrenia, has been well accepted. Consequently, pharmacotherapy would require multitargeted strategies. This contrasts to the majority o...
关键词：POLYPHARMACOLOGY Drug-target NETWORKS NETWORK topology Disease NETWORKS Genome-wide association studies EPIGENETICS Schizophrenia HERBAL extracts 
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