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ZESTE: 作品数：94被引量：178H指数：6; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：吴云艳谷丽娜刘飞桑梅香张惠民更多>>; 相关机构：葛兰素史密斯克莱知识产权(第2号)有限公司中山大学附属第一医院贵州医科大学四川海思科制药有限公司更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金河北省科技支撑计划项目广东省科技计划工业攻关项目国家重点基础研究发展计划更多>>

EZH2,via an association with KDM2B,modulates osteogenic differentiation of root apical papillary stem cells: 《World Journal of Stem Cells》2025年第4期99-112,共14页Hui-Yue Xu Yan-Tong Wang Hao-Qing Yang Yang-Yang Cao Zhi-Peng Fan; Supported by National Key Research and Development Program,No.2022YFA1104401;Beijing Natural Science Foundation,No.7222075;CAMS Innovation Fund for Medical Sciences,No.2019RU020;Innovation Research Team Project of Beijing Stomatological Hospital,No.CXTD202204.; BACKGROUND Stem cells from apical papilla(SCAPs)represent promising candidates for bone regenerative therapies due to their osteogenic potential.However,enhancing their differentiation capacity remains a critical chal...; 关键词：Bioactive peptides Bone tissue engineering Enhancer of zeste homolog 2 OSTEOGENIC Apical papillary stem cell

Gene targets with therapeutic potential in hepatocellular carcinoma: 《World Journal of Gastrointestinal Oncology》2024年第12期4543-4547,共5页Syifaus Shodry Yuliono Trika Nur Hasan Iwal Reza Ahdi Zulvikar Syambani Ulhaq; Hepatocellular carcinoma(HCC)is the third leading cause of cancer-related deaths worldwide.Major treatments include liver transplantation,resection,and chemotherapy,but the 5-year recurrence rate remains high.Late dia...; 关键词：Hepatocellular carcinoma Enhancer of zeste homolog 2 Target genes Biomarkers Potential therapeutic

EZH2 Contributes to Anoikis Resistance and Promotes Epithelial Ovarian Cancer Peritoneal Metastasis by Regulating m6A被引量：2: 《Current Medical Science》2023年第4期794-802,共9页Shao-hai WANG Lin LIU Ke-yong BAO Yi-fan ZHANG Wen-wen WANG Shi DU Na-er JIA Suo SUO Jing CAI Jian-feng GUO Gang LV; funded by the National Natural Science Foundation of China(No.81672573);Natural Science Foundation of Xinjiang Uygur Autonomous Region(No.2021D01F21);Natural Science Foundation of Hubei Province(No.2021CFB474)。; Objective:Histone modification has a significant effect on gene expression.Enhancer of zeste homolog 2(EZH2)contributes to the epigenetic silencing of target chromatin through its roles as a histone-lysine N-methyltra...; 关键词：ANOIKIS heterografts N6-methyladenosine enhancer of zeste homolog 2 ovarian neoplasms

EZH2 is a biomarker associated with lung cancer diagnosis and immune infiltrates without prognostic specificity: a study based on the cancer genome atlas data被引量：1: 《Oncology and Translational Medicine》2023年第3期99-114,共16页Xiaokun Wang Min Qi Xu Zhu Zhengtong Zhao Yufeng Cao Daijun Xing Fuman Wang Gaoyang Lin; Supported by a grant from the Qingdao 2020 Medical Scientific Research Guidance Plan(No.2020-WJZD036).; Enhancer of zeste homolog 2(EZH2)is the catalytic subunit of polycomb repressive complex 2(PRC2).Dysregulation of EZH2 causes alteration of gene expression and functions,thereby promoting cancer development.Recent stu...; 关键词：Enhancer of zeste homolog 2 lung cancer diagnosis prognosis immune infiltrating

miR-124 is upregulated in diabetic mice and inhibits proliferation and promotes apoptosis of high-glucose-inducedβ-cells by targeting EZH2被引量：1: 《World Journal of Diabetes》2023年第3期209-221,共13页Xiao-Kai Duan Yong-Xiang Sun Hong-Yun Wang Yan-Yan Xu Shi-Zhen Fan Jin-Ya Tian Yong Yu Yan-YunZhao Yan-Li Jiang; Supported by The Medical Science and Technology Key Project of Henan Province,No.2018020733.; BACKGROUND Diabetes is a chronic metabolic disease,and a variety of miRNA are involved in the occurrence and development of diabetes.In clinical studies,miR-124 is highly expressed in the serum of patients with diabet...; 关键词：miR-124 Enhancer of zeste homolog 2 Diabetes Insulin secretion PROLIFERATION Apoptosis

Selective EZH2 inhibitor zldl039 alleviates inflammation in cisplatin-induced acute kidney injury partially by enhancing RKIP and suppressing NF-κB p65 pathway被引量：2: 《Acta Pharmacologica Sinica》2022年第8期2067-2080,共14页Li Wen Shao-hua Tao Fan Guo Ling-zhi Li Hong-liu Yang Yan Liang Li-dan Zhang Liang Ma Ping Fu; supported by the National Key R&D Program of China(2020YFC2005000);the National Natural Science Foundation of China(82070711);the Science/Technology Project of Sichuan province(2020YFQ0055);the 1.3.5 project for disciplines of excellence from West China Hospital of Sichuan University(ZYGD18027).; Enhancer of zeste homolog 2(EZH2),a component of polycomb repressive complex 2(PRC2),is a histone lysine methyltransferase mediating trimethylation of histone H3 at lysine 27(H3K27me3),which is a repressive marker at ...; 关键词：acute kidney injury INFLAMMATION enhancer of zeste homolog 2 Raf kinase inhibitor protein NF-κB p65 zld1039

Enhancer of zeste homolog 2 contributes to apoptosis by inactivating janus kinase 2/signal transducer and activator of transcription signaling in inflammatory bowel disease被引量：1: 《World Journal of Gastroenterology》2021年第22期3073-3084,共12页Jie Zhou Yang Yang Yi-Ling Wang Yue Zhao Wen-Jing Ye Si-Yao Deng Jin-Yi Lang Shun Lu; Supported by National Natural Science Foundation of China,No.81900498.; BACKGROUND Inflammatory bowel disease(IBD)is a prevalent worldwide health problem featured by relapsing,chronic gastrointestinal inflammation.Enhancer of zeste homolog 2(EZH2)is a critical epigenetic regulator in diff...; 关键词：Inflammatory bowel disease APOPTOSIS Enhancer of zeste homolog 2 JAK2 Permeability Inflammatory bowel disease therapy

EZH2 mediates mechanisms of AD20 on its inhibitory effects in PC3 cell proliferation and migration: 《中国药理学与毒理学杂志》2019年第9期691-691,共1页LIU Shuai-shuai LI Xue-jun; OBJECTIVE Prostate cancer is the most commonly diagnosed malignancy and the sixth leading cause of cancer death in men.Aberrant upregulation of enhancer of Zeste homolog2(EZH2)occur frequently in human cancers,includi...; 关键词：enhancer of Zeste homolog 2 proliferation MIGRATION

果蝇EZH2与乳腺癌分子分型及临床病理特征的关系被引量：8: 《中国现代医学杂志》2017年第6期50-53,共4页李杰宝喻晓程田野; 湖北省2015年武汉市卫计委临床医学课题(No:WX15B17); 目的探讨果蝇Zeste基因增强子人类同源物2(EZH2)与乳腺癌分子分型及临床病理参数的关系。方法根据新型乳腺癌分子分型标准,将乳腺癌进行分子分型;免疫组织化学方法检测乳腺癌组织石蜡切片中EZH2的表达;采用χ~2检验分析EZH2表达与乳腺...; 关键词：果蝇Zeste基因增强子人类同源物2 乳腺癌分子分型免疫组织化学 ENHANCER of DROSOPHILA ZESTE HOMOLOG 2

Targeting Enhancer of Zeste Homolog 2 as a promising strategy for cancer treatment被引量：1: 《World Journal of Clinical Oncology》2016年第2期135-148,共14页Irene Marchesi Luigi Bagella; Polycomb group proteins represent a global silencing system involved in development regulation.In specific,they regulate the transition from proliferation to differentiation,contributing to stem-cell maintenance and i...; 关键词：ENHANCER of ZESTE HOMOLOG 2 POLYCOMB group proteins HISTONE METHYLTRANSFERASE ENHANCER of ZESTE HOMOLOG 2 inhibitors Anticancer drugs Cancer therapy Epigenetics

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