HOMOLOG

作品数：213被引量：511H指数：10
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相关领域：医药卫生生物学更多>>
相关作者：金敏娜林欣大张海燕刘立新徐杰更多>>
相关机构：中国计量学院山西医科大学第一医院中国医科大学河北医科大学第二医院更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金中国博士后科学基金更多>>
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Qishen Granule protects against myocardial ischemia by promoting angiogenesis through BMP2-Dll4-Notch1 pathway
《Chinese Herbal Medicines》2025年第1期139-147,共9页Yiqin Hong Hui Wang Hanyan Xie Xinyi Zhong Xu Chen Lishuang Yu Yawen Zhang Jingmei Zhang Qiyan Wang Binghua Tang Linghui Lu Dongqing Guo 
supported by the National Natural Science Foundation of China held by LL(No.81904169);Excellent Youth Foundation of BUCM held by DG(No.BUCM-2019-JCRC005)。
Objective:Therapeutic angiogenesis has become a promising approach for treating ischemic heart disease(IHD).The present study aims to investigate the effects of Qishen Granule(QSG)on angiogenesis in myocardial ischemi...
关键词：ANGIOGENESIS bone morphogenetic protein-2 delta-like 4 myocardial ischemia notch homolog 1 Qishen Granule 
Naked cuticle homolog 2 controls the differentiation of osteoblasts and osteoclasts and ameliorates bone loss in ovariectomized mice
《Genes & Diseases》2025年第1期281-297,共17页Liying Shan Xiaoxia Liao Xiaoli Yang Endong Zhu Hairui Yuan Jie Zhou Xiaoxia Li Baoli Wang 
funded by the National Natural Science Foundation of China(No.82072389,82272444,81972033).
Naked cuticle homolog 2(NKD2)has been recognized as an antagonist of Wnt/β-catenin signaling and a tumor suppressor.The role of NKD2 in osteoblast and osteoclast differentiation and the mechanism are not fully unders...
关键词：Mechanistictargetof rapamycincomplex1 Naked cuticle homolog 2 OSTEOBLAST OSTEOCLAST Receptoractivatorof nuclearfactorkB ligand WNT/Β-CATENIN 
The sigma-1 receptor-TAMM41 axis modulates neuroinflammation and attenuates memory impairment during the latent period of epileptogenesis
《Animal Models and Experimental Medicine》2025年第2期197-208,共12页Jianlun Ji Ce Gao Qinghua Wang Xiaoxia Jia Hao Tian Yaqin Wei Zhidong Liu Yun Wang Lin Guo 
This project was supported by grants from the National Natural Science Foundation of China(Grant Nos.81872847 and 82173803);the Science and Technology Planning Project of Xuzhou(Grant No.KC22256);the Science and Technology Developing Fund of The Affiliated Hospital of Xuzhou Medical University(Grant No.2021ZA14)。
Background:Therapy in the latent period is favorable for retarding the process of epileptogenesis.Recently,we have discovered that the activated sigma-1 receptor(Sig-1R)attenuates the hippocampus pathological injury a...
关键词：EPILEPTOGENESIS memory impairment mitochondrial translocator assembly and maintenance 41 homolog NEUROINFLAMMATION sigma-1 receptor 
Electroacupuncture alleviates diabetic peripheral neuropathy through modulating mitochondrial biogenesis and suppressing oxidative stress
《World Journal of Diabetes》2025年第2期133-150,共18页Chong-Xi Yuan Xuan Wang Yun Liu Tian-Cheng Xu Zhi Yu Bin Xu 
National Natural Science Foundation of China,No.82074532,No.82374577,No.82305375,No.82305376,and No.82405567;The Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD).
BACKGROUND Peripheral neuropathy caused by diabetes is closely related to the vicious cycle of oxidative stress and mitochondrial dysfunction resulting from metabolic abnormalities.The effects mediated by the silent i...
关键词：ELECTROACUPUNCTURE Type 2 diabetic peripheral neuropathy Silent matching type information regulation 2 homolog-1/peroxisome proliferator-activated receptor-gamma coactivator-1αaxis Mitochondria biogenesis Oxidative stress 
Sine oculis homeobox homolog family function in gastrointestinal cancer:Progression and comprehensive analysis
《World Journal of Clinical Oncology》2025年第1期10-24,共15页Yang-Zheng Lan Zheng Wu Wen-Jia Chen Xin-Ning Yu Hua-Tao Wu Jing Liu 
Supported by the National Natural Science Foundation of China,No.82273457;the Natural Science Foundation of Guangdong Province,No.2023A1515012762 and No.2021A1515010846;Special Grant for Key Area Programs of Guangdong Department of Education,No.2021ZDZX2040;Science and Technology Special Project of Guangdong Province,No.210715216902829.
The sine oculis homeobox homolog(SIX)family,a group of transcription factors characterized by a conserved DNA-binding homology domain,plays a critical role in orchestrating embryonic development and organogenesis acro...
关键词：Sine oculis homeobox homolog Gastrointestinal cancer Transcription factor Development Regulation Diagnosis THERAPEUTICS 
Gene targets with therapeutic potential in hepatocellular carcinoma
《World Journal of Gastrointestinal Oncology》2024年第12期4543-4547,共5页Syifaus Shodry Yuliono Trika Nur Hasan Iwal Reza Ahdi Zulvikar Syambani Ulhaq 
Hepatocellular carcinoma(HCC)is the third leading cause of cancer-related deaths worldwide.Major treatments include liver transplantation,resection,and chemotherapy,but the 5-year recurrence rate remains high.Late dia...
关键词：Hepatocellular carcinoma Enhancer of zeste homolog 2 Target genes Biomarkers Potential therapeutic 
Cardiovascular and nonalcoholic fatty liver disease:Sharing common ground through SIRT1 pathways
《World Journal of Cardiology》2024年第11期632-643,共12页Kenneth Maiese 
Supported by American Diabetes Association;American Heart Association;NIH NIEHS;NIH NIA;NIH NINDS;NS053956;NIH ARRA.
As a non-communicable disease,cardiovascular disorders have become the lea-ding cause of death for men and women.Of additional concern is that cardio-vascular disease is linked to chronic comorbidity disorders that in...
关键词：AMP-activated protein kinase Cardiovascular disease Diabetes mellitus ERYTHROPOIETIN Metabolic-dysfunction-associated steatotic liver disease NICOTINAMIDE Nicotinamide adenine dinucleotide Nonalcoholic fatty liver disease Silent mating type information regulation 2 homolog 1(Saccharomyces cerevisiae) Stem cells 
Suppression of hepatic steatosis in non-alcoholic steatohepatitis model by modified Xiaoyao San formula:Evidence,mechanisms and perspective
《World Journal of Hepatology》2024年第10期1208-1212,共5页Nabil Eid Payal Bhatnagar Li-Li Chan Marina Garcia-Macia 
In this letter,we comment on a recent publication by Mei et al,in the World Journal of Hepatology,investigating the hepatoprotective effects of the modified Xiaoyao San(MXS)formula in a male rat model of non-alcoholic...
关键词：STEATOSIS Liver Xiaoyao San Inflammation ANDROGEN Adenosine 5’-monophosphate-activated protein kinase Phosphatase and tensin homolog Autophagy Lipophagy Alpha smooth muscle actin 
Mutations in Ras homolog family member A in patients with peripheral T-cell lymphoma and implications for personalized medicine
《Cancer Biology & Medicine》2024年第9期754-768,共15页Lina Hu Xuanye Zhang Shengbing Zang 
This work was supported by the Natural Science Foundation of Guangdong Province(Grant No.2019A1515011354).
Genome sequencing has revealed frequent mutations in Ras homolog family member A(RHOA)among various cancers with unique aberrant profiles and pathogenic effects,especially in peripheral T-cell lymphoma(PTCL).The discr...
关键词：Drug target MUTATION PATHOGENESIS personalized medicine peripheral T-cell lymphoma Ras homolog family member A 
Liver receptor homolog-1:structures,related diseases,and drug discovery
《Acta Pharmacologica Sinica》2024年第8期1571-1581,共11页Tong Wu Zhi-fang Lu Hao-nan Yu Xi-shan Wu Yang Liu Yong Xu 
support from the National Key Research and Development Plan(grant 2022YFE0210600);the Joint Fund of Shandong Natural Science Foundation(grant ZR2022LSW026);the Science and Technology Program of Guangzhou,China(grant 202201010138).
Liver receptor homolog-1(LRH-1),a member of the nuclear receptor superfamily,is a ligand-regulated transcription factor that plays crucial roles in metabolism,development,and immunity.Despite being classified as an‘o...
关键词：nuclear receptor liver receptor homolog 1 liver disease CANCER metabolic disorder small molecule modulators 
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