Supported by National Key Research and Development Program,No.2022YFA1104401;Beijing Natural Science Foundation,No.7222075;CAMS Innovation Fund for Medical Sciences,No.2019RU020;Innovation Research Team Project of Beijing Stomatological Hospital,No.CXTD202204.
BACKGROUND Stem cells from apical papilla(SCAPs)represent promising candidates for bone regenerative therapies due to their osteogenic potential.However,enhancing their differentiation capacity remains a critical chal...
was supported by the National Institutes of Health(NIH)funding programs R01(Nos:CA240301 and CA240423);the Rivkin Pilot Study Award(No.572533),which constituted a crucial resource for conducting our study.
Background:High-grade serous ovarian cancer(HGSOC)accounts for 70-80%of all ovarian cancer-related deaths.Multiple studies have suggested that the fallopian tube epithelium(FTE)serves as the cell of origin of HGSOC.Ph...
supported by the National Natural Science Foundation of China held by LL(No.81904169);Excellent Youth Foundation of BUCM held by DG(No.BUCM-2019-JCRC005)。
Objective:Therapeutic angiogenesis has become a promising approach for treating ischemic heart disease(IHD).The present study aims to investigate the effects of Qishen Granule(QSG)on angiogenesis in myocardial ischemi...
The B lymphoma Mo-MLV insertion region 1 homolog(Bmi-1)protein of the polycomb complex is an essential mediator of the epigenetic transcriptional silencing by the chromatin structure.It has been reported to be crucial...
funded by the National Natural Science Foundation of China(No.82072389,82272444,81972033).
Naked cuticle homolog 2(NKD2)has been recognized as an antagonist of Wnt/β-catenin signaling and a tumor suppressor.The role of NKD2 in osteoblast and osteoclast differentiation and the mechanism are not fully unders...
This project was supported by grants from the National Natural Science Foundation of China(Grant Nos.81872847 and 82173803);the Science and Technology Planning Project of Xuzhou(Grant No.KC22256);the Science and Technology Developing Fund of The Affiliated Hospital of Xuzhou Medical University(Grant No.2021ZA14)。
Background:Therapy in the latent period is favorable for retarding the process of epileptogenesis.Recently,we have discovered that the activated sigma-1 receptor(Sig-1R)attenuates the hippocampus pathological injury a...
National Natural Science Foundation of China,No.82074532,No.82374577,No.82305375,No.82305376,and No.82405567;The Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD).
BACKGROUND Peripheral neuropathy caused by diabetes is closely related to the vicious cycle of oxidative stress and mitochondrial dysfunction resulting from metabolic abnormalities.The effects mediated by the silent i...
Supported by the National Natural Science Foundation of China,No.82273457;the Natural Science Foundation of Guangdong Province,No.2023A1515012762 and No.2021A1515010846;Special Grant for Key Area Programs of Guangdong Department of Education,No.2021ZDZX2040;Science and Technology Special Project of Guangdong Province,No.210715216902829.
The sine oculis homeobox homolog(SIX)family,a group of transcription factors characterized by a conserved DNA-binding homology domain,plays a critical role in orchestrating embryonic development and organogenesis acro...
Hepatocellular carcinoma(HCC)is the third leading cause of cancer-related deaths worldwide.Major treatments include liver transplantation,resection,and chemotherapy,but the 5-year recurrence rate remains high.Late dia...
Supported by American Diabetes Association;American Heart Association;NIH NIEHS;NIH NIA;NIH NINDS;NS053956;NIH ARRA.
As a non-communicable disease,cardiovascular disorders have become the lea-ding cause of death for men and women.Of additional concern is that cardio-vascular disease is linked to chronic comorbidity disorders that in...