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PEPTIDES: 作品数：475被引量：786H指数：11; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：朱毅敏彭师奇黄健张龙辉王国栋更多>>; 相关机构：北京大学中国科学院复旦大学医学部更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家高技术研究发展计划更多>>

Emulsion interfacial polymerization of anticancer peptides:fabricating polypeptide nanospheres with high drug-loading efficiency and enhanced anticancer activity被引量：3: 《Science China Chemistry》2022年第11期2252-2259,共8页Jinpeng Yang Hua Wang Zihe Yin Shuai Zhang Jiang-Fei Xu Xi Zhang; financially supported by the Ministry of Science and Technology of China(2021YFA1501600,2018YFA0208900);the National Natural Science Foundation of China(21821001);the Strategic Priority Research Program of Chinese Academy of Sciences(XDB36000000)。; The development of drug delivery systems with high drug-loading efficiency, kinetic stability against dilution, as well as enhanced anticancer activity is of crucial importance to the fields of self-assembly and nanom...; 关键词：emulsion interfacial polymerization drug delivery anticancer peptide self-assembly acidity-responsive

ISP and PAP4 peptides promote motor functional recovery after peripheral nerve injury被引量：2: 《Neural Regeneration Research》2021年第8期1598-1605,共8页Shi-Qin Lv Wutian Wu; supported by the National Natural Science Foundation of China,No. 81971165;the National Basic Research Program of China (973 Program),No. 2014CB542205 (both to WW)。; Both intracellular sigma peptide(ISP) and phosphatase and tensin homolog agonist protein(PAP4) promote nerve regeneration and motor functional recovery after spinal cord injury. However, the role of these two small pe...; 关键词：AXON brachial plexus injury crush injury intracellular sigma peptide motor function PAP4 peripheral nerve protection regeneration repair

How to use open-pFind in deep proteomics data analysis?-A protocol for rigorous identification and quantitation of peptides and proteins from mass spectrometry data被引量：1: 《Biophysics Reports》2021年第3期207-226,共20页Guangcan Shao Yong Cao Zhenlin Chen Chao Liu Shangtong Li Hao Chi Meng-Qiu Dong; the National Natural Science Foundation of China(grant 21675153 Detail);the Beijing Municipal Science and Technology Commission,and the Ministry of Science and Technology of China for research funding.; High-throughput proteomics based on mass spectrometry(MS)analysis has permeated biomedical science and propelled numerous research projects.pFind 3 is a database search engine for high-speed and in-depth proteomics da...; 关键词：Protein identification Mass spectrometry Search engine Open-pFind QUANTITATION

Supramolecular Peptide Therapeutics:Host-Guest Interaction-Assisted Systemic Delivery of Anticancer Peptides被引量：3: 《CCS Chemistry》2020年第6期739-748,共10页Hua Wang Ya-Qiong Yan Yu Yi Zi-Yu Wei Hao Chen Jiang-Fei Xu Hao Wang Yuliang Zhao Xi Zhang; supported financially by the Ministry of Science and Technology of China(2018YFA0208900 and 2018YFE0205400);the National Natural Science Foundation of China(21821001,21805058,and 51890892).; The poor stability of therapeutic peptides in physiological environments hampers their therapeutic efficacy.In this work,a strategy of supramolecular peptide therapeutics(SPT)was proposed for the improvement of the st...; 关键词：supramolecular chemistry uril cancer therapy anticancer peptide drug delivery

Anisotropic formation mechanism and nanomechanics for the self-assembly process of cross-β peptides: 《Chinese Physics B》2017年第12期18-31,共14页邓礼赵玉荣周鹏徐海王延颋; Project supported by the National Basic Research Program of China(Grant No.2013CB932804);the National Natural Science Foundation of China(Grant Nos.11421063,11647601,11504431,and 21503275);the Scientific Research Foundation of China University of Petroleum(East China)for Young Scholar(Grant Y1304073);financial support through the CAS Biophysics Interdisciplinary Innovation Team Project(Grant No.2060299); Nanostructures self-assembled by cross-β peptides with ordered structures and advantageous mechanical properties have many potential applications in biomaterials and nanotechnologies. Quantifying the intra-and inter-...; 关键词：molecular dynamics simulation peptide self-assembly intermolecular force THERMODYNAMICS

Rational design and functional evolution of targeted peptides for bioanalytical applications被引量：1: 《Science China Chemistry》2016年第10期1250-1257,共8页Yanyan Huang Yulong Jin Rui Zhao; supported by the National Natural Science Foundation of China (21375134, 21475140, 21135006, 21321003);The National Basic Research Program of China (2015CB856300);the Chinese Academy of Sciences; The complicated, highly dynamic and diverse nature of biosystems brings great challenges to the specific analysis of molecular processes of interest. Nature provides antibodies for the specific recognition of antigens...; 关键词：PEPTIDE DESIGN SCREENING targeted analysis biomedical applications

A novel method for identification and relative quantification of N-terminal peptides using metal-element-chelated tags coupled with mass spectrometry: 《Science China Chemistry》2014年第5期708-717,共10页YAN Hui HAO FeiRan CAO QiChen LI JiaBin LI NanNan TIAN Fang BAI HaiHong REN XiaoJun LI XianYu ZHANG YangJun QIAN XiaoHong; supported by the National Basic Research Program of China(2012CB910603,2010CB912701);the National Key Scientific Instrument Development Program of China(2011YQ09000504,2012YQ-12004407,2011YQ06008408);the High-Technology Research and Development Programme of China(2012AA020202);the National Natural Science Foundation of China(20735005,21275159,31100591); By means of the reaction between a DOTA-NHS-ester bifunctional reagent and N-terminal peptides of proteins, and then che- lation of lanthanide metal ions as tags, we established a novel method for the identification o...; 关键词：metal-element-chelated tags N-terminal peptides PROTEOMICS mass spectrometry

Comprehensive analysis of the N and C terminus of endogenous serum peptides reveals a highly conserved cleavage site pattern derived from proteolytic enzymes: 《Protein & Cell》2012年第9期669-674,共6页Fangjun Wang Jun Zhu Lianghai Hu Hongqiang Qin Mingliang Ye Hanfa Zou; supported by the Creative Research Group Project of National Natural Science Foundation of China(Grant No.21021004);the National Basic Research Program(973 Program)(Nos.2012CB910601,2012CB910101);the Analytical Method Innovation Program of MOST(No.2010IM030500)(H.Z.)。; The human serum proteome is closely associated with the state of the body.Endogenous peptides derived from proteolytic enzymes cleaving on serum proteins are widely studied due to their potential application in diseas...; 关键词：human serum endogenous peptide N and C termini disease diagnosis

Temperature-Dependence of the Amide-Ⅰ Frequency Map for Peptides and Proteins: 《Chinese Journal of Chemical Physics》2011年第5期529-537,I0003,共10页韩晨王建平; This work was supported by the National Natural Science Foundation of China （No.30870591）, the National Basic Research Program of China （No.2007CB815205）; and the Chinese Academy of Sciences （Hundred Talent Fund）. Chen Han thanks Dr. Kai-cong Cai for helpful discussions.; In our recent work [Phys. Chem. Chem. Phys. 11, 9149 （2009）], a molecular-mechanics force field-based amidc-Ⅰ vibration frequency map （MM-map） for peptides and proteins was constructed. In this work, the temperat...; 关键词：Amide-Ⅰ Frequency map Infrared spectrum Molecular dynamics simulation

Anti-tumor targeted drug delivery systems mediated by aminopeptidase N/CD13被引量：4: 《Acta Pharmaceutica Sinica B》2011年第2期80-83,共4页Xun Wang Bin Wang Qiang Zhang; This research was supported by the National Basic Research Program of China(No.2009CB930300);State Key Projects(No.2009ZX09310-001);the 863 Project(No.2007AA021811).; Aminopeptidase N(APN)/CD13 is a transmembrane glycoprotein,which is overexpressed on tumor neovascular endothelial cells and most tumor cells,where it plays an important role in tumor angiogenesis.Peptides containing ...; 关键词：Aminopeptidase N/CD13 NGR peptides ANTI-TUMOR Targeted drug delivery system

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