POLYMERSOME

作品数：13被引量：20H指数：3
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相关领域：理学更多>>
相关期刊：《ChemPhysMater》《Chemical Research in Chinese Universities》《Chinese Journal of Polymer Science》《Bioactive Materials》更多>>
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Bioinspired menstrual blood-derived stem cells-conditioned medium/polymersome nanoparticles for the treatment of carbon tetrachloride-induced acute liver failure in mice
《Aggregate》2024年第4期376-385,共10页Zuhong Li Qian Li Xiaoxi Ouyang Shima Tang Qiuhong Liu Yaqi Zhang Yanhong Zhang Xiaopeng Yu Danhua Zhu Ying Mu Lanjuan Li 
National Key Research and Development Program of China,Grant/Award Numbers:2019YFC0840600,2019YFC0840609;Fundamental Research Funds for the Central Universities,Grant/Award Number:2022ZFJH003;Independent Project Fund of the State Key Laboratory for Diagnosis and Treatment of Infectious Disease。
Acute liver failure is a life-threatening syndrome,for which liver transplantation is presently the most effective treatment.Unfortunately,such treatment is extremely limited by a shortage of donor organs.Stem cell th...
关键词：acute liver failure MenSCs-conditioned medium NANOPARTICLES POLYMERSOMES 
Gas-generating polymersomes-based amplified photoimmunotherapy for abscopal effect and tumor metastasis inhibition被引量：1
《Chinese Chemical Letters》2024年第6期456-461,共6页Chenlu Huang Xinyu Yang Qingyu Yu Linhua Zhang Dunwan Zhu 
financially supported by National Natural Science Foundation of China(Nos.82172090,82302390 and 82072059);CAMS Innovation Fund for Medical Sciences(Nos.2021-I2M-1-058 and 2022-I2M-1-023);China Postdoctoral Science Foundation(No.2022M720502);Tianjin Municipal Natural Science Foundation(No.22JCQNJC00070);CAMS Union Young Scholars Support Program(No.2022051);Fundamental Research Funds for the Central Universities(No.2019PT320028)。
Due to the heterogeneity of tumors,single phototherapy cannot completely ablate tumors and inhibit tumor metastasis.To overcome these,we formulated targeted and multifunctional polymersomes ABC@ICGIMQ-LHRH(AIRL)that e...
关键词：POLYMERSOMES PHOTOTHERAPY Immunotherapy TLR 7/8 agonist Gas-generating 
Polymersome-mediated cytosolic delivery of cyclic dinucleotide STING agonist enhances tumor immunotherapy被引量：3
《Bioactive Materials》2022年第10期1-11,共11页Huan Zheng Beibei Guo Xinyun Qiu Yifeng Xia Yan Qu Liang Cheng Fenghua Meng Zhiyuan Zhong 
supported by research grants from the National Natural Science Foundation of China(NSFC 52033006,51861145310,51773146 and 51633005)and the National Key R&D Program of China(2021YFB3800900).
Cyclic dinucleotides(CDNs)as stimulator of interferon genes(STING)agonists capable of inducing strong antitumor innate immune response are highly promising for tumor immunotherapy.The efficacy of these CDNs is,however...
关键词：POLYMERSOMES STING agonists Cyclic dinucleotide Immunotherapy Radiotherapy 
Brain-targeted polymersome codelivery of siRNA and temozolomide for effective glioblastoma chemo-RNAi synergistic therapy
《ChemPhysMater》2022年第3期203-210,共8页Meng Zheng Chengnan Yan Qingshan Yang Feiyan Zhu Qiuli Du Xue Xia Marco Morsch Albert Lee Jinglong Yin Yan Zou Bingyang Shi 
This research was funded by China’s National Key Technologies R&D Programs(2018YFA0209800);National Natural Science Founda tion of China(NSFC 52073079,31800841,32071388,and U1804139);Key Research Program in Colleges and Universities of Henan Province(19zx006);Program of Technology Innovation Team in Colleges and Universities of Henan Province(21IRTSTHN028);NHMRC Investi-gator Grant.
Temozolomide (TMZ) is a clinically approved drug for glioblastoma (GBM) therapy. However, as a result of methylguanine-DNA-methyltransferase (MGMT), which is able to repair damaged DNA-damage repairing, TMZ usually yi...
关键词：POLYMERSOME SIRNA TMZ GLIOBLASTOMA Brain targeting 
Controlling Membrane Phase Separation of Polymersomes for Programmed Drug Release被引量：2
《Chinese Journal of Polymer Science》2022年第9期1006-1015,共10页Shuai Chen Erik Jan Cornel Jian-Zhong Du 
financially supported by the National Natural Science Fund for Distinguished Young Scholars (No. 21925505);Shanghai International Scientific Collaboration Fund (No. 21520710100);supported by the National Natural Science Foundation of China (No. 22101207);the China Postdoctoral Science Foundation (No. 2020M671197);International Postdoctoral Exchange Fellowship Program
Programmed release of small molecular drugs from polymersomes is of great importance in drug delivery.A significant challenge is to adjust the membrane permeability in a well-controlled manner.Herein,we propose a stra...
关键词：POLYMERSOME Drug delivery Phase separation Programmed drug release 
A pH-responsive polymersome depleting regulatory T cells and blocking A2A receptor for cancer immunotherapy
《Nano Research》2022年第3期2324-2334,共11页Binfen Shao Xuehui Huang Funeng Xu Jingmei Pan Yi Wang Shaobing Zhou 
the National Natural Science Foundation of China(Nos.51725303 and 52033007).
The immunosuppressive tumor microenvironment(ITM)and low immunogenicity of tumors greatly limit cancer immunotherapy efficacy.The approach of solely depleting regulatory T cells(Tregs)cannot ameliorate ITM,but possibl...
关键词：POLYMERSOME regulatory T cells adenosine A2A pathway immunogenic cell death IMMUNOTHERAPY 
Polymersome formation by solvent annealing-induced structural reengineering under 3D soft confinement
《Nano Research》2021年第12期4644-4649,共6页Xi Mao Hao Li Jinwoo Kim Shuai Deng Renhua Deng Bumjoon J.Kim Jintao Zhu 
We gratefully acknowledge the financial support from the National Natural Science Foundation of China(No.52003094);the Fundamental Research Funds for the Central Universities(No.2020kfyXJJS011)。
A solvent annealing-induced structural reengineering approach is exploited to fabricate polymersomes from block copolymers that are hard to form vesicles through the traditional solution self-assembly route.More speci...
关键词：POLYMERSOME block copolymer three-dimensional(3D)confinement SELF-ASSEMBLY solvent annealing 
Synthesis and self-assembly of poly(ethylene glycol)-block-poly(N-3-(methylthio)propyl glycine)and their oxidation-sensitive polymersomes被引量：4
《Chinese Chemical Letters》2020年第7期1931-1935,共5页Yangwei Deng Hui Chen Xinfeng Tao Sylvain Trepout Jun Ling Min-Hui Li 
the French National Research Agency(No.ANR16-CE29-0028);the National Natural Science Foundation of China(No.21674091);the Joint Foundation of Shaanxi Province Natural Science Basic Research Program;Shaanxi Coal Chemical Group Co.,Ltd.(No.2019JLM-46)for financial support;the China Scholarship Council for funding his Ph.D.scholarship in France。
Amphiphilic block copolymers poly(ethylene glycol)-block-poly(N-3-(methylthio)propyl glycine)(PEGb-PMeSPG)were synthesized via ring-opening polymerization of N-3-(methylthio)propyl glycine Nthiocarboxyanhydride(MeSPG-...
关键词：Polypeptoid SELF-ASSEMBLY POLYMERSOME Oxidation-responsive Glucose oxidase 
Polymersomes scalably fabricated via flash nano- precipitation are non-toxic in non-human primates and associate with leukocytes in the spleen and kidney following intravenous administration被引量：3
《Nano Research》2018年第10期5689-5703,共15页Sean D. Allen Yu-Gang Liu Sharan Bobbala Lei Cai Peter I. Hecker Ryan Temel Evan A. Scott 
Vesicular nanocarrier formulations confer the ability to deliver hydrophobic and hydrophilic cargos simultaneously to cells of interest in vivo. While liposomal formulations reached the clinic long ago, younger techno...
关键词：POLYMERSOME non-human primate NANOPRECIPITATION toxicity BIODISTRIBUTION 
Highly uniform ultrasound-sensitive nanospheres produced by a pH-induced micelle-to-vesicle transition for tumor-targeted drug delivery被引量：4
《Nano Research》2018年第7期3710-3721,共12页Yiru Wang Tinghui Yin Zhenwei Su Chen Qiu Yong Wang Rongqin Zheng Meiwan Chen Xintao Shuai 
This work was supported by the National Basic Research Program of China （No. 2015CB755500）, the National Natural Science Foundation of China （Nos. U1401242, 51225305, and 81430038）, the Natural Science Foundation of the Guangdong Province （No. 2014A030312018）, the Guangdong Innovative and Entrepreneurial Research Team Program （No. 2013S086）, and the Macao Science and Technology Development Fund （No. 096/2015/A3）.
Although gas-filled microbubbles with high echogenicity are widely applied in clinical ultrasonography, the micron scale particle size impedes their use in the treatment of solid tumors, which are accessible to object...
关键词：MICELLE POLYMERSOME morphological transition ultrasound-sensitive tumor-penetratingdelivery 
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