EXONS

作品数：33被引量：77H指数：4
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相关领域：医药卫生生物学更多>>
相关作者：童庆王煦法宁岩郑浩然更多>>
相关机构：中国科学技术大学更多>>
相关期刊：《Journal of Ocean University of China》《Cellular & Molecular Immunology》《Science China(Life Sciences)》《World Journal of Gastroenterology》更多>>
相关基金：国家自然科学基金国家高技术研究发展计划安徽省自然科学基金国家重点基础研究发展计划更多>>
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Differential Splicing of Skipped Exons Predicts Drug Response in Cancer Cell Lines
《Genomics, Proteomics & Bioinformatics》2021年第6期901-912,共12页Edward Simpson Steven Chen Jill L.Reiter Yunlong Liu 
supported by the National Institutes of Health,USA(Grant No.R01CA213466)awarded to YL.;the Precision Health Initiative at Indiana University.
Alternative splicing of pre-mRNA transcripts is an important regulatory mechanism that increases the diversity of gene products in eukaryotes.Various studies have linked specific transcript isoforms to altered drug re...
关键词：Alternative splicing Transcript isoform Splicing regulation Drug sensitivity Precision medicine 
Mutational analysis of Ras hotspots in patients with urothelial carcinoma of the bladder被引量：1
《World Journal of Clinical Oncology》2020年第8期614-628,共15页Kiran Tripathi Apul Goel Atin Singhai Minal Garg 
BACKGROUND Mutational activation of Ras genes is established as a prognostic factor for the genesis of a constitutively active RAS-mitogen activated protein kinase pathway that leads to cancer.Heterogeneity among the ...
关键词：Coding exons Oncogenic activation Polymerase chain reaction-restriction fragment length polymorphism Point mutations Ras genes Urothelial carcinoma of bladder 
Physiological and druggable skipping of immunoglobulin variable exons in plasma cells
《Cellular & Molecular Immunology》2019年第10期810-819,共10页Mohamad Omar Ashi Nivine Srour Jean-Marie Lambert Anne Marchalot Ophelie Martin Sandrine Le Noir Eric Pinaud Maria Victoria Ayala Christophe Sirac Jerome Sauliere Jerome Moreaux Michel Cogne Laurent Delpy 
supported by grants from Fondation ARC(PJA 20161204724/PGA120150202338);INCa(PLBIO15-256);ANR(2017-CE15-0024-01);Ligue Contre le Cancer(comites Correze,Haute-Vienne);Fondation Française pour la Recherche contre le Myelome et les Gammapathies monoclonales(FFRMG);Comited’Organisation de la Recherche sur le Cancer du Limousin(CORC).
The error-prone V(D)J recombination process generates considerable amounts of nonproductive immunoglobulin(Ig)pre-mRNAs.We recently demonstrated that aberrant Ig chains lacking variable(V)domains can be produced after...
关键词：IMMUNOGLOBULIN Exon skipping Plasma cells Antisense Oligonucleotides Nonsense-associated altered splicing 
Phylogenomic delineation of Physcomitrium (Bryophyta: Funariaceae) based on targeted sequencing of nuclear exons and their flanking regions rejects the retention of Physcomitrella, Physcomitridium and Aphanorrhegma被引量：4
《Journal of Systematics and Evolution》2019年第4期404-417,共14页Rafael Medina Matthew G. Johnson Yang Liu Norman J. Wickett A. Jonathan Shaw Bernard Goffinet 
Selection on spore dispersal mechanisms in mosses is thought to shape the transformation of the sporophyte. The majority of extant mosses develop a sporangium that dehisces through the loss of an operculum, and regula...
关键词：cleistocarpy Entosthodon MOSSES PHYLOGENETICS TARGETED enrichment 
Modeling and analysis of RNA-seq data： a review from a statistical perspective被引量：5
《Frontiers of Electrical and Electronic Engineering in China》2018年第3期195-209,共15页Wei Vivian Li Jingyi Jessica Li 
Background： Since the invention of next-generation RNA sequencing （RNA-seq） technologies, they have become a powerful tool to study the presence and quantity of RNA molecules in biological samples and have revoluti...
关键词：RNA-SEQ statistical modeling differentially expressed genes alternatively spliced exons isoformreconstruction and quantification 
Relative benefits of amino-acid, codon, degeneracy, DNA, and purine-pyrimidine character coding for phylogenetic analyses of exons
《Journal of Systematics and Evolution》2017年第2期85-109,共25页Mark P. Simmons 
Both traditional as well as 10 more recent methods of coding characters from exons of protein-coding genes are reviewed. The more recent methods collectively blur the distinction between nucleotide and amino-acid codi...
关键词：character-state space codon models composite characters phylogenetic signal PHYLOGENOMICS plastomics saturation transcriptomics. 
Plant Proteins Are Smaller Because They Are Encoded by Fewer Exons than Animal Proteins被引量：2
《Genomics, Proteomics & Bioinformatics》2016年第6期357-370,共14页Obed Ramirez-Sachez Paulino Perez-Rodriguez Luis Delaye Axel Tiessen 
supported by basic grants from CONACYT–Mexico to AT and LD;a scholarship to ORS(Grant No.347589/237183)
Protein size is an important biochemical feature since longer proteins can harbor more domains and therefore can display more biological functionalities than shorter proteins. We found remarkable differences in protei...
关键词：Digital proteome EUKARYA Evolution Viridiplantae Polypeptide length 
Clinical outcomes of EGFR-TKI treatment and genetic heterogeneity in lung adenocarcinoma patients with EGFR mutations on exons 19 and 21被引量：20
《Chinese Journal of Cancer》2016年第4期171-180,共10页Jiang-Yong Yu Si-Fan Yu Shu-Hang Wang Hua Bai Jun Zhao Tong-Tong An Jian-Chun Duan Jie Wang 
supported by grants from the National Natural Sciences Foundation Key Program(No.81330062);Education Ministry Innovative Research Team Program(No.IRT13003);Peking University-Tsinghua University Joint Center for Life Sciences Clinical Investigator,National High Technology Research and Development Program 863(No.SS2015AA020403);Beijing Technology Project(No.Z141100000214013)
Background:Epidermal growth factor receptor(EGFR) mutations,including a known exon 19 deletion(19 del) and exon 21 L858 R point mutation(L858R mutation),are strong predictors of the response to EGFR tyrosine kinase in...
关键词：EGFR EXON 19 DELETION EGFR EXON 21 L858R point mutation Lung ADENOCARCINOMA TREATMENT efficacy 
A novel large deletion(exons 12,13)and a missense mutation(p.G46R)in the PAH in a Japanese patient with phenylketonuria
《World Journal of Pediatrics》2015年第2期181-184,共4页Yoshihiro Maruo Masafumi Suzaki Katsuyuki Matsui Yu Mimura Asami Mori Haruo Shintaku Yoshihiro Takeuchi 
Background:Phenylketonuria(PKU)is caused by a defect in phenylalanine hydroxylase(PAH).More than 500 mutations have been reported for the gene encoding PAH.However,approximately l%-5%of these include large deletions a...
关键词：large deletion multiplex ligation-dependent probe amplification phenylalanine hydroxylase PHENYLKETONURIA 
The Unexpected Existence of Coding and Non-Coding Fragments along the Eukaryotic Gene
《Advances in Biological Chemistry》2015年第2期98-125,共28页Pietro Volpe 
The pathways leading to synthesis and post-synthetic modification of DNA employed methionine as donor of atoms: the carbon that came from its –CH3 served for DNA replication and repair either in bacteria or humans;it...
关键词：CODING vs. NON-CODING Pre-Messenger RNA Regions EXONS and INTRONS Multigenic and MONOGENIC TRANSCRIPTIONAL Units Regulation of Gene Expression Repair-Modification 
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