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SPIKE: 作品数：309被引量：519H指数：9; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：赵为华王如彬张林琦史宣玲刘克林更多>>; 相关机构：广州医科大学厦门大学浙江大学北京大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家高技术研究发展计划更多>>

Enhanced potency of an IgM-like nanobody targeting conserved epitope in SARS-CoV-2 spike N-terminal domain: 《Signal Transduction and Targeted Therapy》2024年第6期2726-2737,共12页Bo Liu Honghui Liu Pu Han Xiaoyun Wang Chunmei Wang Xinxin Yan Wenwen Lei Ke Xu Jianjie Zhou Jianxun Qi Ruiwen Fan Guizhen Wu Wen-xia Tian George F.Gao Qihui Wang; supported by the National Key R&D Program of China(2022YFC2303403);the National Science Fund for Distinguished Young Scholars(82225021);supported by the Young Scientists in Basic Research(YSBR-010).; Almost all the neutralizing antibodies targeting the receptor-binding domain(RBD)of spike(S)protein show weakened or lost efficacy against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)emerged or emerging...; 关键词：doses prevention CONSERVED

Host cyclophilin A facilitates SARS-CoV-2 infection by binding and stabilizing spike on virions: 《Signal Transduction and Targeted Therapy》2024年第1期36-39,共4页Xiangpeng Sheng Fang Zhu Hong Peng Fan Yang Yi Yang Cong Yang Zhen Wang Wei Chen Deyin Guo Ronggui Hu; funded by the National Science and Technology Innovation 2030 Major Project of China(No.2021ZD0203900);the Ministry of Science and Technology of China(No.2019YFA0802103);the Department of Science and Technology of Zhejiang Province(No.2021C03104);the Guangzhou Science Innovation and Development Program(No.201803010092);the Shenzhen-Hong Kong Institute of Brain Science(No.NYKFKT2019006);the National Natural Science Foundation of China(No.92253302);the Construction Project of Collaborative Response and Intervention Platform for Chinese and Western Medicine(No.ZY2018-2020-FWTX-7004).; Dear Editor,The novel coronavirus SARS-CoV-2 rapidly evolutes to increase its infectivity and transmissibility,facilitates its immune escape,impairs vaccine efficacy,and currently causes repeated infections in human,w...; 关键词：ACE2 VACCINE INFECTION

SARS-CoV-2 spike-specific TFH cells exhibit unique responses in infected and vaccinated individuals被引量：1: 《Signal Transduction and Targeted Therapy》2023年第11期5338-5352,共15页Rongzhang He Xingyu Zheng Jian Zhang Bo Liu Qijie Wang Qian Wu Ziyan Liur Fangfang Chang Yabin Hu Ting Xie Yongchen Liu Jun Chen Jing Yang Shishan Teng Rui Lu Dong Pan You Wang Liting Peng Weijin Huang Velislava Terzieva Wenpei Liu Youchun Wang Yi-Ping Li Xiaowang Qu; the National Natural Science Foundation of China(92269115,82061138020,32270996,82102365);The Science and Technology Innovation Program of Hunan Province of China(2022RC3079);Natural Science Foundation of Hunan Province of China(2021JJ40006,2022JJ30095);Educational Commission of Hunan Province of China(21A0529);The Clinical Medical Innovation Technology Guide Project of Hunan Province(2021SK50304,2021SK50306 and 2021SK50312);General Project of Health Commission of Hunan Province(B202303087545,D202302076189);SC1-PHE-CORONAVIRUS-2020:"Advancing knowledge for the clinical and public health response to the 2019-nCoV epidemic"from the European Commission(CORONADX,no.101003562)(Y.-P.L);NSF KP-06-DK-3/2(2020),Republic of Bulgaria.; Long-term humoral immunity to SARS-CoV-2 is essential for preventing reinfection. The production of neutralizing antibody (nAb)and B cell differentiation are tightly regulated by T follicular help (T_(FH)) cells. Howe...; 关键词：VACCINE doses protective

Rough operators: sphingomyelinase inhibitors spike NK cells to kill cancer: 《Signal Transduction and Targeted Therapy》2023年第9期3892-3893,共2页Mattias Carlsten Yenan T.Bryceson; This work was supported by grants from the Swedish Cancer Foundation and Swedish Research Council(to M.C.and Y.T.B.);the Knut and Alice Wallenberg Fellows program(to Y.T.B.).; In a recent study published in Nature Immunology,Zheng et al.discovered that intratumoral NK cells were smooth and rounded as opposed to the typical vili-rich,rougher surface of normal NK cells.1 This phenotype was li...; 关键词：MYELIN IMPAIRED CANCER

Relevance of Spike/Estrogen Receptor-αinteraction for endothelial-based coagulopathy induced by SARS-CoV-2: 《Signal Transduction and Targeted Therapy》2023年第6期2459-2462,共4页Silvia Stella Barbieri Franca Cattani Leonardo Sandrini Magda Maria Grillo Alessandra Amendola Carmen Valente Carmine Talarico Daniela Iaconis Gabriele Turacchio Miriam Lucariello Lucia Lione Erika Salvatori Patrizia Amadio Gloria Garoffolo Mariano Maffei Francesca Galli Andrea Rosario Beccari Giuseppe Sberna Emanuele Marra Marica Zoppi Michael Michaelides Giuseppe Roscilli Luigi Aurisicchio Riccardo Bertini Marcello Allegretti Maurizio Pesce; Dear Editor,The severe coagulation syndrome in numerous organs is the major life-threatening conditions characterizing the acute infection by SARS-CoV-2.Endothelial inflammation/dysfunction,platelet hyper-reactivity,g...; 关键词：ORGANS INFECTION acute

Mutation N856K in spike reduces fusogenicity and infectivity of Omicron BA.1: 《Signal Transduction and Targeted Therapy》2023年第3期908-911,共4页Chunyun Sun Huiyu Wang Ji Yang Desheng Kong Yuning Chen Haiyue Wang Lingling Sun Jianbo Lu Min Teng Liangzhi Xie; Beijing Municipal Science and Technology Commission(Z211100002521026).; Dear Editor,COVID-19 lung pathology is characterized by interstitial pneumonia with cell-cell fusion-induced syncytia and extensive tissue damage.1 The correlation between viral fusogenicity and pathogenicity has been...; 关键词：LUNG PATHOLOGY DAMAGE

Hide and seek with SARS-CoV-2: spike receptor-binding domain-specific memory B cells still recognize Omicron variant: 《Signal Transduction and Targeted Therapy》2022年第11期3973-3975,共3页Ivan Odak Reinhold Förster Berislav Bošnjak; Research in the Förster lab gets supported by the German Center for Infection Research TTU 01.938(grant no 80018019238);German Center for Lung Research(grant 82DZL002B1);Deutsche Forschungsgemeinschaft(DFG,German Research Foundation)Excellence Strategy EXC 2155“RESIST”(Project ID39087428);SFB 900/3(Project B1,158989968)and FO334/7-1(all to RF).; Sokal et al.reported recently in Immunity that the SARS-CoV-2 Omicron variant evades recognition by 70%of anti-spike protein antibodies generated by memory B cells(MBCs)from mRNA vaccine-immunized individuals that wer...; 关键词：vaccine ANTIBODIES

Structural insights into the Omicron spike trimer:tackling the challenges of continuously evolving SARS-CoV-2 variants被引量：1: 《Signal Transduction and Targeted Therapy》2022年第10期3625-3627,共3页Junxian Ou Jianguo Wu Qiwei Zhang; supported by grants from the National Key Research and Development Program of China(2018YFE0204503);National Natural Science Foundation of China(32170139 and 81730061);Natural Science Foundation of Guangdong Province(2021A1515010788 and 2022A1515011190);the Fundamental Research Funds for the Central Universities(21622101).; The recent studies published in Science and Cell Research investigated the structures and biochemical mechanism of the SARS-CoV-2 Omicron BA.1 and BA.2 spike trimer with ACE2 as well as an effective antibody JMB2002 a...; 关键词：ACE2 INSIGHT continuously

A robust reporting system for measurement of SARS-CoV-2 spike fusion efficiency: 《Signal Transduction and Targeted Therapy》2022年第7期2141-2143,共3页Cong Huang Yang Yang Peng Yang Fei Wang Xinyu Li Xiang Song Yiming Wang Cuiyun Yu Xuejun Wang Shengqi Wang; financially supported by the National Key R&D Project of China 2018YFA0902300;the National Natural Science Foundation of China 81830101;the Biological Safety Project 19SWAQ08;the Medical Innovation Project 17SAZ13 and Beijing Nova Program Z171100001117119.; Dear Editor,During the COVID-19 pandemic,several SARS-CoV-2 variants such as Alpha,Delta,and Omicron successively became dominant worldwide.The infection of SARS-CoV-2 is triggered by the binding of spike protein to t...; 关键词：ACE2 PATHOGENESIS SEVERITY

Tracking SARS-CoV-2 Omicron diverse spike gene mutations identifies multiple inter-variant recombination events被引量：4: 《Signal Transduction and Targeted Therapy》2022年第5期1808-1816,共9页Junxian Ou Wendong Lan Xiaowei Wu Tie Zhao Biyan Duan Peipei Yang Yi Ren Lulu Quan Wei Zhao Donald Seto James Chodosh Zhen Luo Jianguo Wu Qiwei Zhang; We gratefully acknowledge the authors,originating and submitting laboratories of the sequences from GISAID’s EpiCoV™Database that this study used.This work was supported by grants from the National Key Research and Development Program of China(2018YFE0204503);National Natural Science Foundation of China(32170139 and 81730061);Natural Science Foundation of Guangdong Province(2018B030312010,2021A1515010788,and 2022A1515011190);the Fundamental Research Funds for the Central Universities(21622101);Guangdong Science and Technology Program key projects(2021B1212030014).; The current pandemic of COVID-19 is fueled by more infectious emergent Omicron variants.Ongoing concerns of emergent variants include possible recombinants,as genome recombination is an important evolutionary mechanis...; 关键词：subsequent diverse recombination

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