ENDOTOXIN

作品数:255被引量:1096H指数:16
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相关领域:医药卫生更多>>
相关作者:李兰娟马伟杭吴仲文陈亚岗俞云松更多>>
相关机构:浙江大学医学院附属第一医院复旦大学南京大学大连医科大学更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划北京市自然科学基金高等学校学科创新引智计划更多>>
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Gut Microbiota and Cytokine Profile in Cirrhosis
《Journal of Clinical and Translational Hepatology》2024年第8期689-700,共12页Irina Efremova Roman Maslennikov Anna Kudryavtseva Anastasia Avdeeva George Krasnov Mikhail Diatroptov Vyacheslav Bakhitov Salekh Aliev Natalia Sedova Maria Fedorova Elena Poluektova Oxana Zolnikova Nariman Aliev Anna Levshina Vladimir Ivashkin 
supported by the Biocodex Microbiota Foundation(National Research Grant Russia 2019).The sponsor did not participate in the development of the study design,influence the conduct of the study,data analysis,or the decision to publish.
Background and Aims:Gut dysbiosis and abnormal cytokine profiles are common in cirrhosis.This study aimed to evaluate the correlations between them.Methods:In the blood plasma of cirrhosis patients and controls,27 cyt...
关键词:ENDOTOXIN Leaky gut Gut microbiome Systemic inflammation Gut-liver axis ENDOTOXEMIA 
Regulatory Effect of JAK2/STAT3 on the Immune Function of Endotoxin-tolerant Dendritic Cells and its Involvement in Acute Liver Failure被引量:1
《Journal of Clinical and Translational Hepatology》2022年第5期879-890,共12页Yukai Chen Chaochen Hou Naibin Yang Yanyan Yang Youran Chen Deyong Kong Yuchun Jiang Minghao Lin Sijie Zheng Shanshan Li Mingqin Lu 
supported by Zhejiang Provincial Natural Science Foundation of China under Grant No.LY18H030010.
Background and Aims:Acute liver failure(ALF)is a potentially fatal clinical syndrome with no effective treatment.This study aimed to explore the role of Janus kinase 2/signal transducer and activator of transcription ...
关键词:Liver failure Acute Janus kinase 2/signal transducers and activators of transcription 3(JAK2/STAT3) Endotoxin tolerance Dendritic cells 
Simvastatin Improves Outcomes of Endotoxin-induced Coagulopathy by Regulating Intestinal Microenvironment被引量:1
《Current Medical Science》2022年第1期26-38,共13页Min XU Li-li LUO Meng-yi DU Lu TANG Jie ZHOU Yu HU Heng MEI 
This study was supported by grants from the National Natural Science Foundation of China(No.81873434)and the Natural Science Foundation of Hubei Province(No.2020CFA065).
Objective:The systemic inflammatory response is regarded as the major cause of endotoxin-induced coagulopathy,which is a strong predictor of mortality in patients with severe sepsis.Simvastatin plays an important role...
关键词:ENDOTOXEMIA endotoxin-induced coagulopathy SIMVASTATIN inflammatory cytokines intestinal permeability intestinal microorganism 
The gut-cardiovascular connection: new era for cardiovascular therapy被引量:1
《Medical Review》2021年第1期23-46,共24页Chak Kwong Cheng Yu Huang 
supported by Hong Kong RGC-Senior Research Fellow Scheme(SRFS2021-4S04);National Natural Science Foundation of China(91939302).
Our gut microbiome is constituted by trillions of microorganisms including bacteria,archaea and eukaryotic microbes.Nowadays,gut microbiome has been gradually recognized as a new organ system that systemically and bio...
关键词:cardiovascular diseases DYSBIOSIS ENDOTHELIUM ENDOTOXIN fecal microbiota transplantation gut microbiome. 
Effects of Dachengqi Decoctions Made from Raw Rhubarb and Vinegar-processed Rhubarb on Levels of Endotoxin,NO and TNF-αin Serum
《Medicinal Plant》2020年第3期70-73,共4页Wen ZHONG Zujie QIN Jiangcun WEI Zhen XIE Xiumei MA Xianyi SHI Fengxian ZHAO Qian HAN 
National Natural Science Foundation of China(No.81360524);Youth Foundation of Guangxi University of Chinese Medicine(No.2019QN036);Project for Improving Basic Scientific Research Ability of Young and Middle-aged Teachers in Colleges and Universities of Guangxi in 2019(No.2019KY0341);Traditional Chinese Medicine Scientific Research Laboratory(Grade III)of National Administration of Traditional Chinese Medicine:Laboratory of Chinese(Zhuang)Medicine Chemical and Quality Analysis(Guo Zhong Yi Yao Fa 2009[21]).
[Objectives]The effects of Dachengqi decoctions made from raw rhubarb and vinegar-processed rhubarb on serum endotoxin,NO and TNF-αlevels were investigated.[Methods]Total 105 mice were randomly divided into Dachengqi...
关键词:RHUBARB Dachengqi decoction ENDOTOXIN NO TNF-α 
Combined deficiency of SLAMF8 and SLAMF9 prevents endotoxin-induced liver inflammation by downregulating TLR4 expression on macrophages被引量:9
《Cellular & Molecular Immunology》2020年第2期153-162,共10页Xiaokang Zeng Guangao Liu Wanwen Peng Junming He Chenxu Cai Wei Xiong Shasha Chen Meixiang Yang Zhongjun Dong 
This work was supported by grants from the National Natural Science Foundation of China(81725007,81771666,and 81471523);Natural Science Foundation of Beijing Municipality(5172018);111 Project(B16201).
Classical signaling lymphocyte activating molecule(SLAM)family receptors are abundant within many types of immune cells,whereas the nonclassical SLAM family receptors SLAMF8 and SLAMF9,which uniquely lack cytoplasmic ...
关键词:Nonclassical SLAM family receptors Liver inflammation MACROPHAGE TLR4 MAPK 
Effects of Bifidobacterium infantis on cytokine-induced neutrophil chemoattractant and insulin-like growth factor-1 in the ileum of rats with endotoxin injury被引量:7
《World Journal of Gastroenterology》2019年第23期2924-2934,共11页Wei Wang Mei Sun Yu-Ling Zheng Liu-Yu Sun Shu-Qiang Qu 
Supported by the Education Department of Heilongjiang Province,China,No.11521124
BACKGROUND The digestive tract is the maximal immunizing tissue in the body, and mucosal integrity and functional status of the gut is very important to maintain a healthy organism. Severe infection is one of the most...
关键词:BIFIDOBACTERIUM ILEUM Cytokine-induced neutrophil CHEMOATTRACTANT INSULIN-LIKE growth factor-1 RATS 
Rifaximin ameliorates hepatic encephalopathy and endotoxemia without affecting the gut microbiome diversity被引量:15
《World Journal of Gastroenterology》2017年第47期8355-8366,共12页Kosuke Kaji Hiroaki Takaya Soichiro Saikawa Masanori Furukawa Shinya Sato Hideto Kawaratani Mitsuteru Kitade Kei Moriya Tadashi Namisaki Takemi Akahane Akira Mitoro Hitoshi Yoshiji 
AIM To determine the efficacy of rifaximin for hepatic encephalopathy(HE) with the linkage of gut microbiome in decompensated cirrhotic patients.METHODS Twenty patients(12 men and 8 women; median age, 66.8 years; rang...
关键词:gut microbiome Hepatic encephalopathy Liver cirrhosis ENDOTOXIN RIFAXIMIN 
Sodium butyrate attenuates high-fat diet-induced steatohepatitis in mice by improving gut microbiota and gastrointestinal barrier被引量:95
《World Journal of Gastroenterology》2017年第1期60-75,共16页Da Zhou Qin Pan Feng-Zhi Xin Rui-Nan Zhang Chong-Xin He Guang-Yu Chen Chang Liu Yuan-Wen Chen Jian-Gao Fan 
the State Key Development Program for Basic Research of China,No.2012CB517501;National Natural Science Foundation of China,No.81070322,No.81270491,No.81470840 and No.31400001;100 Talents Program,No.XBR2011007h
AIM To investigate whether gut microbiota metabolite sodium butyrate (NaB) is an effective substance for attenuating non-alcoholic fatty liver disease (NAFLD) and the internal mechanisms. METHODS Male C57BL/6J mice we...
关键词:Non-alcoholic fatty liver disease Sodium butyrate Gut microbiota Gastrointestinal barrier ENDOTOXIN 
Anti-CD163-dexamethasone conjugate inhibits the acute phase response to lipopolysaccharide in rats被引量:1
《World Journal of Hepatology》2016年第17期726-730,共5页Karen Louise Thomsen Holger Jon Moller Jonas Heilskov Graversen Nils E Magnusson Soren K Moestrup Hendrik Vilstrup Henning Gronbaek 
Supported by The NOVO Nordisk foundation;the Aarhus University Research Foundation;Clinical Institute,Aarhus University,Denmark
AIM: To study the effect of a new anti-CD163-dexamethasone conjugate targeting activated macrophages on the hepatic acute phase response in rats. METHODS: Wistar rats were injected intravenous with either the CD163 ta...
关键词:Acute phase response DEXAMETHASONE ENDOTOXIN Hemoglobin scavenger receptor CD163 Cytokines Inflammation RATS 
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