supported by the Biocodex Microbiota Foundation(National Research Grant Russia 2019).The sponsor did not participate in the development of the study design,influence the conduct of the study,data analysis,or the decision to publish.
Background and Aims:Gut dysbiosis and abnormal cytokine profiles are common in cirrhosis.This study aimed to evaluate the correlations between them.Methods:In the blood plasma of cirrhosis patients and controls,27 cyt...
supported by Zhejiang Provincial Natural Science Foundation of China under Grant No.LY18H030010.
Background and Aims:Acute liver failure(ALF)is a potentially fatal clinical syndrome with no effective treatment.This study aimed to explore the role of Janus kinase 2/signal transducer and activator of transcription ...
This study was supported by grants from the National Natural Science Foundation of China(No.81873434)and the Natural Science Foundation of Hubei Province(No.2020CFA065).
Objective:The systemic inflammatory response is regarded as the major cause of endotoxin-induced coagulopathy,which is a strong predictor of mortality in patients with severe sepsis.Simvastatin plays an important role...
supported by Hong Kong RGC-Senior Research Fellow Scheme(SRFS2021-4S04);National Natural Science Foundation of China(91939302).
Our gut microbiome is constituted by trillions of microorganisms including bacteria,archaea and eukaryotic microbes.Nowadays,gut microbiome has been gradually recognized as a new organ system that systemically and bio...
National Natural Science Foundation of China(No.81360524);Youth Foundation of Guangxi University of Chinese Medicine(No.2019QN036);Project for Improving Basic Scientific Research Ability of Young and Middle-aged Teachers in Colleges and Universities of Guangxi in 2019(No.2019KY0341);Traditional Chinese Medicine Scientific Research Laboratory(Grade III)of National Administration of Traditional Chinese Medicine:Laboratory of Chinese(Zhuang)Medicine Chemical and Quality Analysis(Guo Zhong Yi Yao Fa 2009[21]).
[Objectives]The effects of Dachengqi decoctions made from raw rhubarb and vinegar-processed rhubarb on serum endotoxin,NO and TNF-αlevels were investigated.[Methods]Total 105 mice were randomly divided into Dachengqi...
This work was supported by grants from the National Natural Science Foundation of China(81725007,81771666,and 81471523);Natural Science Foundation of Beijing Municipality(5172018);111 Project(B16201).
Classical signaling lymphocyte activating molecule(SLAM)family receptors are abundant within many types of immune cells,whereas the nonclassical SLAM family receptors SLAMF8 and SLAMF9,which uniquely lack cytoplasmic ...
Supported by the Education Department of Heilongjiang Province,China,No.11521124
BACKGROUND The digestive tract is the maximal immunizing tissue in the body, and mucosal integrity and functional status of the gut is very important to maintain a healthy organism. Severe infection is one of the most...
AIM To determine the efficacy of rifaximin for hepatic encephalopathy(HE) with the linkage of gut microbiome in decompensated cirrhotic patients.METHODS Twenty patients(12 men and 8 women; median age, 66.8 years; rang...
the State Key Development Program for Basic Research of China,No.2012CB517501;National Natural Science Foundation of China,No.81070322,No.81270491,No.81470840 and No.31400001;100 Talents Program,No.XBR2011007h
AIM To investigate whether gut microbiota metabolite sodium butyrate (NaB) is an effective substance for attenuating non-alcoholic fatty liver disease (NAFLD) and the internal mechanisms. METHODS Male C57BL/6J mice we...
Supported by The NOVO Nordisk foundation;the Aarhus University Research Foundation;Clinical Institute,Aarhus University,Denmark
AIM: To study the effect of a new anti-CD163-dexamethasone conjugate targeting activated macrophages on the hepatic acute phase response in rats. METHODS: Wistar rats were injected intravenous with either the CD163 ta...