Severe alcoholic hepatitis (sAH) is defined by a modified discriminant function ≥32 or model for end-stage liver disease (MELD) >20. Patients with sAH are in an immu-nocompromised state attributed to cirrhosis-relate...
Common variable immunodeficiency (CVID) is one of the most prevalent primary immunodeficiency disorders, characterized by an alteration in the maturation of B lymphocytes. Patients with this condition are redisposed t...
Key Research and Development Project, Department of Science and Technology, Sichuan Province(Nos. 2018SZ0212 and 2018JY0383);Fundamental Research Funds for the Central Universities, Project of Sichuan Health and Family Planning Commission(No. 18PJ015)
To the Editor:There have been growing concerns about the gut bacterial dysbiosis associated with HIV infection,addressing a critical role of gut bacteria in persistent chronic inflammation and severe intestinal dysfun...
Objective To investigate the clinical features of amoebic enteritis with acquired immunodeficiency syndrome (AIDS) patients.Methods The clinical data of patients diagnosed with amoebic enteritis in Beijing Ditan Hospi...
the National Natural Science Foundation of China,No.81741103.
BACKGROUND Interleukin 10 receptor alpha subunit(IL10RA)dysfunction is the main cause of very early-onset inflammatory bowel disease(VEO-IBD)in East Asians.AIM To identify disease-causing gene mutations in four patien...
This work was supported by intramural program at the National Institutes of Health.
Introduction Chronic granulomatous disease(CGD)is a rare immunodeficiency affecting approximately 1 in 200,000 people[1].Patients with CGD are unable to produce normal amounts of neutrophil superoxide and other phagoc...
Liver injury is a characteristic feature of human immunodeficiency virus(HIV) infection, which is the second most common cause of mortality in HIV-infected patients. Now it is recognized that liver plays a key role in...
Supported by Zhejiang Province Medical Platform Backbone,No.2017KY436
AIM To analyze clinical differences between monogenic and nonmonogenic very-early-onset inflammatory bowel disease(VEO-IBD) and to characterize monogenic IBD phenotypically and genotypically via genetic testing. METHO...
AIM To assess the incidence of hepatocellular carcinoma(HCC) in chronic liver disease due to hepatitis B virus(HBV) or hepatitis C virus(HCV) coinfected with human immunodeficiency virus(HIV).METHODS A retrospective c...