INFLAMMASOME

作品数：391被引量：2615H指数：23
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相关作者：韩蓉吴东明吴玉章许颖陈永文更多>>
相关机构：第二军医大学广州医科大学华中科技大学安徽医科大学更多>>
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  • 期刊=Chinese Journal of Natural Medicinesx
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Reynosin protects neuronal cells from microglial neuroinflammation by suppressing NLRP3 inflammasome activation mediated by NADPH oxidase
《Chinese Journal of Natural Medicines》2024年第6期486-500,共15页YANG Yanqiu CHE Yue FANG Mingxia YAO Xiaohu ZHOU Di WANG Feng CHEN Gang LIANG Dong LI Ning HOU Yue 
supported by the National Natural Science Foundation of China(No.82174076);the Construction Project of Liaoning Provincial Key Laboratory,China(No.2022JH13/10200026);the Fundamental Research Funds for the Central Universities(No.N2220002),the 111 Project(No.B16009);Scientific Research Fund of Liaoning Province Education Department(No.LJKZ0945);Natural Science Foundation of Liaoning Province(No.2022-MS-242).
Neuroinflammation,mediated by the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing-3(NLRP3)inflammasome,is a significant contributor to the pathogenesis of neurodegenerative disea...
关键词：MICROGLIA NLRP3 inflammasome Reactive oxygen species NADPH oxidase Neuron Reynosin 
Paeoniflorin alleviates depression by inhibiting the activation of NLRP3 inflammasome via promoting mitochondrial autophagy被引量：1
《Chinese Journal of Natural Medicines》2024年第6期515-529,共15页SU Lili GUO Pengli GUO Xiangjuan HE Zhongmei ZHAO Yan ZONG Ying LI Jianming CHEN Weijia DU Rui 
supported by the Jilin Science&Technology Development Plan(Nos.20210204001YY,20200404090YY);Jilin Province aid Project for Xinjiang Uygur Autonomous Region(No.0207-202020043).
Depression ranks among the most common neuropsychiatric disorders globally.Current studies examining the roles of inflammation and mitochondrial autophagy in the antidepressant efficacy of paeoniflorin(PF)are sparse.T...
关键词：PAEONIFLORIN DEPRESSION AUTOPHAGY NLRP3 inflammasome 
Yanggan Jiangmei Formula alleviates hepatic inflammation and lipid accumulation in non-alcoholic steatohepatitis by inhibiting the NF-κB/NLRP3 signaling pathway被引量：1
《Chinese Journal of Natural Medicines》2024年第3期224-234,共11页WU Yuanyuan ZHOU Jingwen ZUO Xinchen KUANG Yufeng SUN Lixia ZHANG Xiaolong 
supported by the National Natural Science Foundation of China(No.8200151236);the Postgraduate Research Practice Innovation Program of Jiangsu Province(No.KYCX22_1903);the Outstanding Clinical Talents of Traditional Chinese Medicine in Jiangsu Province(No.18,Jiangsu Science and Education of Traditional Chinese Medicine[2017]).
The role of NF-κB and the NLRP3 inflammasome in the chronic inflammatory microenvironment of non-alcoholic steatohepatitis(NASH)has been posited as crucial.The Yanggan Jiangmei Formula(YGJMF)has shown promise in amel...
关键词：Non-alcoholic steatohepatitis Nuclear factor kappa B NLRP3 inflammasome Yanggan Jiangmei Formula 
An inulin-type fructan CP-A from Codonopsis pilosula attenuates experimental colitis in mice by promoting autophagy-mediated inactivation of NLRP3 inflammasome
《Chinese Journal of Natural Medicines》2024年第3期249-264,共16页ZHOU Jiangtao WANG Jun WANG Jiajing LI Deyun HOU Jing LI Jiankuan BAI Yun’e GAO Jianping 
supported by the National Natural Science Foundation of China(No.81904031);National Key Research and Development Program of China(No.2019YFC1710800);the Natural Science Foundation of Shanxi Province(No.201901D211325);the Science Research Start-up Fund for Doctor of Shanxi Medical University(No.XD1802).
Inulin-type fructan CP-A,a predominant polysaccharide in Codonopsis pilosula,demonstrates regulatory effects on immune activity and anti-inflammation.The efficacy of CP-A in treating ulcerative colitis(UC)is,however,n...
关键词：Inulin-type fructan CP-A Codonopsis pilosula Ulcerative colitis NLRP3 inflammasome AUTOPHAGY 
10,11-Dehydrocurvularin attenuates inflammation by suppressing NLRP3 inflammasome activation
《Chinese Journal of Natural Medicines》2023年第3期163-171,共9页ZHAO Qun FENG Mengyuan JIN Shu LIU Xiaobo LI Shengbao GUO Jian CHENG Xinran ZHOU Guangbiao YU Xianjun 
the National Natural Science Foundation of China(No.81902852);China Postdoctoral Science Foundation(No.2020M670220);the Natural Science Foundation of Hubei Province of China(No.2022CFB481);the Natural Science Foundation of Hubei Provincial Department of Education(No.T2022021);Wudang Local Chinese Medicine Research of Hubei University of Medicine(No.WDCM2020004).
10,11-Dehydrocurvularin(DCV)is a natural-product macrolide that has been shown to exert anti-inflammatory activity.However,the underlying mechanism of its anti-inflammatory activity remains poorly understood.Aberrant ...
关键词：10 11-Dehydrocurvularin INFLAMMATION NLRP3 inflammasome NEK7-NLRP3 interaction 
Sinkihwan-gamibang ameliorates puromycin amino nucleoside-induced nephrotic syndrome被引量：2
《Chinese Journal of Natural Medicines》2022年第3期177-184,共8页Lee Hyeon Kyoung Jang Youn Jae Na Se Won Kim Hye Yoom Han Bywig Hyuk Lee Yun Jung Lee Ho Sub Yoon Jung Joo Kang Dae Gill 
supported by the National Research Foundation of Korea(NRF)grant funded by the Korean government(MSIP)(Nos.2017R1A5A2015805,2021R1A2C1010859,and 2021R1C1C2009542).
Nephrotic syndrome(NS)is a kidney disease characterized by hypertriglyceridemia,massive proteinuria,hypo-albuminemia and peripheral edema.Sinkihwan-gamibang(SKHGMB)was recorded in a traditional Chinese medical book na...
关键词：Sinkihwan-gamibang Puromycin aminonucleoside Nephrotic syndrome Renal dysfunction NLRP3 inflammasome Fibrosis 
Mangiferin inhibited neuroinflammation through regulating microglial polarization and suppressing NF-κB,NLRP3 pathway被引量：17
《Chinese Journal of Natural Medicines》2021年第2期112-119,共8页LEI Li-Yan WANG Rui-Cheng PAN Ya-Lei YUE Zheng-Gang ZHOU Rui XIE Pei TANG Zhi-Shu 
the National Natural Science Foundation of China(No.81603357);the Natural Science Basic Research Plan in Shaanxi Province of China(No.2017.Q8043);the Scientific Research Program Funded by Shaanxi Provincial Education Department(No.20JY011).
Inflammation plays important roles in the progress of neurodegenerative diseases,such as Parkinson’s disease and Alzheimer’s disease.Microglia is responsible for the homeostasis of the central nervous system(CNS),an...
关键词：MANGIFERIN Inflammation Microglial polarization NF-ΚB NLRP3 inflammasome 
Norisoboldine, a natural aryl hydrocarbon receptor agonist, alleviates TNBS-induced colitis in mice, by inhibiting the activation of NLRP3 inflammasome被引量：11
《Chinese Journal of Natural Medicines》2018年第3期161-174,共14页LV Qi WANG Kai QIAO Si-Miao DAI Yue WEI Zhi-Feng 
supported by the Natural Science Foundation of Jiangsu Province of China(No.BK20140662);partially supported by the National Natural Science Foundation of China(No.81503319);the Priority Academic Program Development of Jiangsu Higher Education Institutions
Although the etiology of inflammatory bowel disease is still tmcertain, increasing evidence indicates that the excessive activation of NLRP3 inflammasome plays a major role. Norisoboldine （NOR）, an alkaloid isolated...
关键词：Norisoboldine Inflammatory bowel disease NLRP3 inflammasome Aryl hydrocarbon receptor 
Siwu decoction attenuates oxonate-induced hyperuricemia and kidney inflammation in mice被引量：12
《Chinese Journal of Natural Medicines》2016年第7期499-507,共9页WANG Rong MA Chun-Hua ZHOU Fan KONG Ling-Dong 
supported by Natural Science Foundation of China(Nos.81025025 and J1210026);Changjiang Scholars and Innovative Research Team in University(IRT 14R27)
The aim of the study was to investigate the effects of Siwu decoction on hyperuricemia, kidney inflammation, and dysfunction in hyperuricemic mice. Siwu decoction at 363.8, 727.5, and 1 455 mg·kg^(–1) was orally adm...
关键词：Siwu DECOCTION HYPERURICEMIA Renal organic ion TRANSPORTER NLRP3 INFLAMMASOME KIDNEY INFLAMMATION 
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