the Natural Science Foundation of China(32170155,31770191);the Major Science and Technology Projects of Hubei Province(2021ABA005)to Z.F.L。
Pseudorabies virus(PRV),an etiological agent of pseudorabies in livestock,has negatively affected the porcine industry all over the world.Epithelial cells are reported as the first site of PRV infection.However,the ro...
This work was supported by the Program of Sichuan Veterinary Medicine and Drug Innovation Group of China Agricultural Research System(SCCXTD-2020-18);the Science and Technology Project of Sichuan Province,China(2018NZ0043,2018NZ0064 and 2018HH0076).
Pseudorabies virus(PRV),in the family Herpesviridae,is a pathogen of Aujeszky’s disease,which causes great economic losses to the pig industry.Recent outbreaks of Pseudorabies imply that new control measures are urge...
This work was supported by the General Program of National Natural Science Foundation of China(Grants No.31571432/31802252);the Hunan Provincial Natural Science Foundation of China(Grant No.2015JC3097/2020JJ4041);the Postgraduate Scientific Research Innovation Project of Hunan Province(CX20200659).
Pseudorabies(PR),also called Aujeszky's disease,is a highly infectious disease caused by pseudorabies virus(PRV).Without specific host tropism,PRV can infect a wide variety of mammals,including pig,sheep,cattle,etc.,t...
supported by the National Key Research&Development Program of China(2016YFD0500102);Key Research&Development Program of Zhejiang Province(Grant No.2020C02011);the Fundamental Research Funds for the Central Universities(2017FZA6018)
Circular RNAs(circ RNAs)belong to a class of non-coding RNAs with diverse biological functions.However,little is known about their roles in case of pseudorabies virus(Pr V)infection.Here,we analyzed the expression pro...
supported by Ten-thousand Talents Program [Dr.Xiangdong Li];National Key Research and Development Program 2018ZX10101002,2016YFD0500401;the Development Grant of State Key Laboratory of Infectious Disease Prevention and Control 2015SKLID505;Scientific Research Project of China CDC JY18-1-01。
Pseudorabies virus(PRV),a veterinary pathogen that infects domestic animals as well as wild animals such as wild boar and feral swine,was recently reported to infect human and led to endophthalmitis and encephalitis.A...
financially supported by the National Key Research and Development Program of China (2017YFD0500101);the Natural Science Foundation of Jiangsu Province (BK20170721);the China Association for Science and Technology Youth Talent Lift Project (2017-2019)
Since late 2011,outbreaks of pseudorabies virus(PRV)have occurred in southern China causing major economic losses to the pig industry.We previously reported that variant PRV forms and recombination in China could be t...
the National Science and Technology Major Project of China(No. 2018ZX10301405);the National Natural Science Foundation of China(Nos. 21775111, 21475099)
Virus spread is closely related to pathogenesis.Traditional research methods of virus spread do not distinguish cell-to-cell spread from cell-free spread.The uncertainty of virus induced plaque and virus spread direct...
financially supported by the National Key Research and Development Program of China(No.2017YFD0500103);the Beijing Natural Science Foundation(No.5152023);the National Natural Science Foundation of China(No.31772747 and31272385);the Jilin Province Science and Technology Development Projects(20150204077NY);the Graduate Innovation Fund of Jilin University;the Program for Chang jiang Scholars;the University Innovative Research Team(No.IRT1248)
CRISPR/Cas9-mediated genome editing can inhibit virus infection by targeting the conserved regions of the viral genomic DNA. Unexpectedly, we found previously that pseudorabies virus(PRV) could escape from CRISPR/Cas9...