DIMETHYLNITROSAMINE

作品数:15被引量:188H指数:6
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相关领域:医药卫生更多>>
相关作者:郑希元孙懿蒲小平赵欣更多>>
相关机构:北京大学更多>>
相关期刊:《Agricultural Biotechnology》《Journal of Chinese Pharmaceutical Sciences》《Chinese Journal of Integrative Medicine》《Chinese Journal of Natural Medicines》更多>>
相关基金:国家自然科学基金上海市自然科学基金更多>>
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Salvianolate Reduces Glucose Metabolism Disorders in Dimethylnitrosamine-Induced Cirrhotic Rats被引量:1
《Chinese Journal of Integrative Medicine》2018年第9期661-669,共9页TANG Li-rui TAO Yan-yan LIU Cheng-hai WANG Hai-nan 
Supported by the National Science and Technology Major Project(No.2014ZX10005001);the International S&T Cooperation Program of China(No.2014DFA31440);"Three Year Action Plan" for Development of Traditional Chinese Medicine in Shanghai(No.ZY3CCCX-2-1003);Shanghai Clinical Key Laboratory of Traditional Chinese Medicine(No.14DZ2273200)
Objective: To evaluate the preventive effect of salvianolate (Sal B) on glucose metabolism disorders of dimethylnitrosamine (DMN)-induced cirrhotic rats. Methods: Fiffy-five Wistar rats were randomly divided int...
关键词:SALVIANOLATE FIBROSIS cirrhosis insulin resistance GLYCOGEN METFORMIN 
Effects of Aqueous Extract of Plumbago zeylanica L. in the Reversal of DMN-induced Hepatic Fibrosis in Rat被引量:3
《Agricultural Biotechnology》2017年第3期64-70,共7页Yue PENG Xuelin DUAN Tiejian ZHAO Yanfei WEI Guiyu LI Lulu LIU 
Supported by National Natural Science Foundation of China(81403189,81460628,81660705,81560690);Scientific Research Project for Higher Education of Guangxi Zhuang Autonomous Region Education Department(YB2014182)
[ Objectives ] This study was conducted to evaluate the action of the aqueous extract of a medicinal plant Plumbago zeylanica L. in the reversal of dime- thylnitrosamine (DMN) -induced hepatic fibrosis in rats, and ...
关键词:Plumbago zeylanica L. Aqueous extract Dimethylnitrosamine (DMN) Anti-hepatic fibrosis 
Antifibrotic Effect of Total Flavonoids of Astmgali Radix on Dimethylnitrosamine-lnduced Liver Cirrhosis in Rats被引量:8
《Chinese Journal of Integrative Medicine》2017年第1期48-54,共7页CHENG Yang MAI Jing-yin WANG Mei-feng CHEN Gao-feng PING Jian 
Supported by the Shanghai Natural Science Foundation(N0.10ZR1430700);Three-Year Plan of Action of Traditional Chinese Medicine in Shanghai(No.ZY3-RCPY-1-1011)
Objective:To study the effect of total flavonoids of Astmgali Radix(TFA)on liver cirrhosis induced with dimethylnitrosamine(DMN)in rats,and the effect on peroxisome proliferator-activated receptorγ(PPARγ),unc...
关键词:total flavonoids of Astmgali Radix DIMETHYLNITROSAMINE liver cirrhosis peroxisome proliferator-activated receptor γ uncoupling protein 2 farnesoid X receptor RAT 
Umbilical cord-derived mesenchymal stem cells alleviate liver fibrosis in rats被引量:20
《World Journal of Gastroenterology》2016年第26期6036-6048,共13页Ning-Li Chai Xiao-Bin Zhang Si-Wen Chen Ke-Xing Fan En-Qiang Linghu 
Supported by National Natural Science Foundation of China,No.81072913
AIM: To evaluate the efficacy of umbilical cord-derived mesenchymal stem cells(UC-MSCs) transplantation in the treatment of liver fibrosis.METHODS: Cultured human UC-MSCs were isolated and transfused into rats with li...
关键词:Liver fibrosis Mesenchymal stem CELLS KUPFFER CELLS INTERLEUKIN-4 DIMETHYLNITROSAMINE DMN 
Chinese medicine CGA formula ameliorates DMN- induced liver fibrosis in rats via inhibiting MMP2/9, TIMP1/2 and the TGF-β/Smad signaling pathways被引量:39
《Acta Pharmacologica Sinica》2016年第6期783-793,共11页Xue-mei LI Jing-hua PENG Zhao-lin SUN Hua-jie TIAN Xiao-hua DUAN Lin LIU Xin MA Qin FENG Ping LIU Yi-yang HU 
Aim: Chinese medicine CGA formula consists of polysaccharide from Cordyceps sinensis mycelia (CS-PS), gypenosides and amygdalin, which is derived from Fuzheng Huayu (FZHY) capsule for treating liver fibrosis. In ...
关键词:Chinese medicine CGA formula Fuzheng Huayu capsule  liver fibrosis DIMETHYLNITROSAMINE TGF-1 Smad MMP2/9 TIMP1/2 
Silibinin alleviates N-nitrosodimethylamine-induced glutathione dysregulation and hepatotoxicity in rats被引量:1
《Chinese Journal of Natural Medicines》2016年第1期40-47,共8页Devaraj Ezhilarasan Slvanesan Karthikeyan 
supported by the DST-INSPIRE(Department of Science and Technology,Government of India Innovation in Science Pursuit for Inspired Research)fellowship(Award No:DST/INSPIRE Fellowship/2010/dated 16.03.2010)
The present study was designed to evaluate the hepatoprotective and antioxidant potentials of silibinin(SBN)against N-nitrosodimethylamine(DMN)-induced toxic insults in the rat liver.The liver damage was induced in Wi...
关键词:DIMETHYLNITROSAMINE SILIBININ Oxidative stress HEPATOTOXICITY GLUTATHIONE DYSREGULATION 
Effects of Salvia miltiorrhiza injectional powder on the development of liver fibrosis initiated by dimethylnitrosamine in rats被引量:5
《Journal of Chinese Pharmaceutical Sciences》2015年第1期54-62,共9页杨莹帆 孙懿 赵欣 郑希元 蒲小平 
Salvia miltiorrhiza (Sm) is a traditional herbal medicine with multiple effects on various diseases. Its water-soluble parts have been used to produce injectional powder. In this study, liver fibrosis rats were indu...
关键词:Salvia miltiorrhiza Liver fibrosis DIMETHYLNITROSAMINE Transforming growth factor-β1 Platelet derived growth factor 
Antifi brotic effects of green tea on in vitro and in vivo models of liver fibrosis被引量:6
《World Journal of Gastroenterology》2009年第41期5200-5205,共6页Hye Kyung Kim Taik-Hoon Yang Hong-Yon Cho 
Supported by A Korea University Grant
AIM: To examine the protective effect of green tea extract (GT) on hepatic fi brosis in vitro and in vivo in dimethylnitrosamine (DMN)-induced rats.METHODS: HSC-T6, a rat hepatic stellate cell line, was used as an in ...
关键词:DIMETHYLNITROSAMINE Green tea extract HSC-T6 cell Liver fibrosis Rat model Type 1 collagen 
Preventive effect of Qianggan-Rongxian Decoction on rat liver fibrosis被引量:5
《World Journal of Gastroenterology》2008年第22期3569-3573,共5页Chun-Hui Li Li-Hui Pan Zong-Wei Yang Chun-Yu Li Wen-Xie Xu 
the Research Program of Department of Scienceand Technology of Hebei Province, No. 200721047
AIM: To study the preventive effects of Qianggan-Rongxian Decoction on liver fibrosis induced by dimethylnitrosamine (DMN) in rats. METHODS: Male Wistar rats were randomly divided into hepatic fibrosis model group, co...
关键词:Liver fibrosis Qianggan-Rongxian Decoction Prevention Rat model DIMETHYLNITROSAMINE 
Upregulation of TNF-α mRNA in hepatic fibrosis rats induced by dimethylnitrosamine被引量:1
《Journal of Medical Colleges of PLA(China)》2007年第5期279-282,共4页张斌 王灵台 
Objective:To observe the expression level of TNF-α mRNA in rats with hepatic fibrosis induced by dimethylnitrosamine (DMN) and to explore its relationship with collagen metabolism and its diagnostic value for hepatic...
关键词:RATS hepatic fibrosis  dimethylnitrosamine TNF-Α 
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