funding from the Medical Research Council (MR/S006990/1, MR/Y010949/1);the Rosetrees Trust (M806);the UCL Neurogenetic Therapies Programme funded by The Sigrid Rausing Trust and the UCL Therapeutic Acceleration Support scheme supported by funding from MRC IAA 2021 UCL MR/X502984/1 (to JNS)。
Charcot-Marie-Tooth disease(CMT) is a heterogeneous group of inherited peripheral neuro pathies;it is characterized by muscle weakness and wasting,as well as sensory dysfunction,that typically begins during adolescenc...
supported by the Michael J Fox Foundation (to PA and FZ)。
The lysosomal enzyme β-glucocerebrosidase(GCase) belongs to the family of glycosidases and hydrolyses the glycosphingolipid glucosylceramide(GluCer) into glucose and ceramide. The enzyme is of central importance for ...
supported by the Deutsche Forschungsgemeinschaft(DFG,German Research Foundation):project ID 431549029-SFB 1451(to MS).
Immune-mediated neuropathies are rare diseases of the peripheral nervous system(PNS),substantially affecting patients’functionality and quality of life.They are amenable to immunomodulatory treatments,which in many c...
Lysophospholipids are metabolites of glycerophospholipids and sphingolipids that are commonly found as lipid constituents of cell membranes.In addition to their function as structural membrane components,certain membe...
Neuropathy is nerve damage that can cause chronic neuropathic pain, which is challenging to cure and has a significant financial burden. Exercise therapies, including High-Intensity Interval Training (HIIT) and steady...
Complex diseases often involve the interplay between genetic and environmental factors. Charcot-Marie-Tooth type 2neuropathies (CMT2) are a group of genetically heterogeneous disorders, in which similar peripheral neu...
This work was supported by grants from the Ministry of Science and Technology of China(2017YFA0104002);the Chinese Academy of Sciences(XDA16010202);the National Natural Science Foundation of China(81730099).
Promoting adult neurogenesis in the enteric nervous system(ENS)may be a potential therapeutic approach to cure enteric neuropathies.Enteric glial cells(EGCs)are the most abundant glial cells in the ENS.Accumulating ev...
supported by the National Natural Science Foundation of China (61405028 to J.Z.,81770935 to H.B.Z.);Fundamental Research Funds for the Central Universities (University of Electronic Science and Technology of China)(ZYGX2019J053 to J.Z.);Department of Science and Technology of Sichuan Province,China (2020YJ0445 to H.B.Z.)。
Glaucoma is characterized by the progressive loss of retinal ganglion cells (RGCs),although the pathogenic mechanism remains largely unknown.To study the mechanism and assess RGC degradation,mouse models are often use...
AIM: To describe the clinical characteristics and treatments associated with antibody positive optic neuropathies including anti-myelin oligodendrocyte glycoprotein(MOG) and anti-aquaporin 4(AQP4), alongside diagnosti...
Supported by the Konkuk University Medical Center Research Grant 2020.
BACKGROUND Neuropathy is a common chronic complication in type 2 diabetes mellitus(T2DM).Statin and metformin are commonly used medications in T2DM patients,and some studies showed statin-or metformin-induced neuropat...