the National Natural Science Foundation of China(grant no.22171260);the K.C.Wong Education Foundation(grant no.GJTD-2020-08);the Bureau of Science and Technology(grant no.XLYC2002080)of Liaoning Province for financial support.
Autotandem catalysis(ATC)is fascinating since a single catalyst can promote tandem reactions involving two or more mechanisms in a single reactor and is a highly desirable approach to realize multifarious transformati...
financially sponsored by the National Key Research and Development Program of China(No.2021YFC2102804);the National Natural Science Foundation of China(No.22078096)。
A new continuous-flow process for the enzymatic synthesis of optically pureγ-lactones,which are used as flavors and fragrances in the food and cosmetic industries,was developed in a three-dimensional microfluidic rea...
We thank the National Key Research and Development Program of China(2021YFF0701700);the National Natural Science Foundation of China(21971252,21991122,22271181);the Science and Technology Commission of Shanghai Municipality(22ZR1423600)for financial support.
Due to its unique electronic properties,the difluoromethylene group(CF2)has served as a valuable unity in the design of biologically active molecules.Sinceγ-lactones display a broad range of biological properties,α,...
supported by the National Natural Science Foundation of China(No.52173093);Peking University Ge Li and Ning Zhao Life Science Research Fund for Young Scientists.
The short lifespan of most commercial plastics as disposables and the failure to adequately address the end-of-life issues of synthetic polymers have led to outrageous global plastic pollution and resource depletion.T...
Generous support from ERC Advanced Grant 101021358 and the DFG Gottfried Wilhelm Leibniz award(L.A.)is gratefully acknowledged.E.R.thanks the Basque Government(Grupos IT1558-22)for financial support.
While electrocatalyzed alkyne annulations of arenes represent a powerful strategy for the assembly of heteroaromatic motives,electrochemical C(sp2)−H activations of alkenes remain scarce.Herein,a strategy for the rhod...
supported by the National Major Research and Development Plan (No. 2018YFA0209402);the National Natural Science Foundation of China (Nos. 21673045, 22088101)。
Chiral glycosyl lactone is an important class of bioactive compound and pharmaceutical intermediate in nature, especially for chiral lactones with 4 carbon atoms, which are very useful building blocks for synthesis of...
financed in part by the Coordenaç˜ao de Aperfeiçoamento de Pessoal de Nível Superior-Brazil-Finance Code 001.
The lactones belong to a class of organic compounds relevant to the flavors and fragrances industry by imparting fruity,creamy,and aromatic notes with application in various products in the food,beverage,and cosmetics...
supported by the National Key R&D Program of China(No.2020YFA0710201);the Science and Technology Commission of Shanghai Municipality(20ZR1471400);the Shanghai Rising Star Program(21QA1402800);the Fundamental Research Funds for the Central Universities.
By introducing hydroxyl group into PPh3 ligand,a promoter-free palladium catalytic system based on(p-HOC6H4)PPh2 ligand was developed for the telomerization of 1,3-butadiene with CO_(2).High activity and selectivity t...
supported by the National Natural Science Foundation of China(21822103,21820102003,91956201);the Program of Introducing Talents of Discipline to Universities of China(111Program,B17019);the Natural Science Foundation of Hubei Province(2017AHB047);Hubei International Scientific and Technological Cooperation Base of Pesticide and Green Synthesis。
Concise synthesis of eight-membered lactones,a kind of medium-sized heterocycles widespread in many bioactive natural products,is highly significant.However,it still remains a challenge due to unfavorable entropic fac...
Supported by the National Science Foundation-funding Project:Study of the Attenuating Effects of 3-dehydroandrographolide on Acute Lung Injury through Modulating Alveolar Macrophage Polarization via Targeting α7n ACh R (No. 81973544);the Guangzhou Education Bureau University Scientific Research Project:Construction of Traditional Chinese Medicine Discipline (no. 201831845);the Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme:Study on the Mechanisms of Anti-Tumor and AntiInflammatory Components from Traditional Chinese Medicine based on Detoxification Therapy (No. GDHVPS2018);the Young Elite Scientists Sponsorship Program by CACM:Study on the Mechanisms of Antitumor Components from Traditional Chinese Medicine based on Detoxification Therapy (No. 2019-QNRC2-C14)。
OBJECTIVE: To systematically evaluate the in vivo antiinflammatory potential of diterpene lactones from Chuanxinlian(Herba Andrographitis Paniculatae)(AP). METHODS: We firstly adopted zebrafish, a novel and ideal anim...