ANTIVIRAL

作品数：505被引量：1623H指数：17
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CAR-NK cell therapy:a potential antiviral platform
《Science Bulletin》2025年第5期765-777,共13页Ming-Hao Lin Li-Juan Hu Jeffrey S.Miller Xiao-Jun Huang Xiang-Yu Zhao 
National Natural Science Foundation of China(82350105,and 82270228);Noncommunicable Chronic Diseases-National Science and Technology Major Project(2023ZD0501200);Science,Technology&Innovation Project of Xiongan New area(2023XACX0004);Beijing Outstanding Young Scientists Project(JWZQ20240101001);Beijing Natural Science Foundation(Z240019),Beijing Nova Program(20220484235).
Viral infections persist as a significant cause of morbidity and mortality worldwide.Conventional therapeutic approaches often fall short in fully eliminating viral infections,primarily due to the emergence of drug re...
关键词：NK cell therapy VIRUS CAR-NK cell therapy Optimization strategies 
Activation and counteraction of antiviral innate immunity by KSHV: an update被引量：2
《Science Bulletin》2018年第18期1223-1234,共12页Xiaoqin Wei Ke Lan 
supported by the National Key R&D Program of China (2016YFA0502100);the Natural Science Foundation for Distinguished Young Scholars (81425017);the National Institutes of Health (7R01AI116442) to K.L.
The innate immune responses triggering production of type 1 interferons and inflammatory cytokines constitute a nonspecific innate resistance that eliminates invading pathogens including viruses. The acti- vation of i...
关键词：KSHV PRRS Innate immune response Evasion strategies 
Functional genomic studies on an immune-and antiviral-related gene of MyD88 in orange-spotted grouper,Epinephelus coioides被引量：2
《Chinese Science Bulletin》2012年第25期3277-3287,共11页YAN Yang CUI HuaChun WEI JingGuang HUANG YouHua HUANG XiaoHong QIN QiWei 
supported by the National Basic Research Program of China (2012CB114402);the Knowledge Innovation Program of the Chinese Academy of Sciences (KZCX2-YW-BR-08 and KZCX2- EW-Q213);the National Natural Science Foundation of China (30725027 and 30930070)
Myeloid differentiation factor 88(MyD88) is a universal adaptor protein involved in Toll-like receptors and in interleukin-1 receptor-induced nuclear factor-kappaB(NF-κB) activation.In this study,a new MyD88 gene(des...
关键词：抗病毒相关基因 功能基因组学 石斑鱼 免疫相关 Toll样受体 核因子-κB 氨基酸序列 死亡结构域 
Identification of antiviral- relevant genes in the cultured fish cells induced by UV-inactivated virus被引量：17
《Chinese Science Bulletin》2003年第6期581-588,共8页ZHangYibing ZHANGQiya 等 
UV-inactivated grass carp hemorrhage virus (GCHV) can induce high titer of interferon in cultured CAB (crucian carp (Carassius auratus L.) blastulae) cells, and thus defend host cells against the virus invasion. The m...
关键词：草鱼出鱼病毒 紫外光灭活病毒 鱼胚细胞系 鱼肾细胞系 诱导 抗病毒相关基因 免疫相关基因 干扰素 
A Novel Fusion Protein Possessing Both Antiviral and pHSA-binding Activities Composed of Hepatitis B Virus Pre-S2 Peptide and Human α2a-interferon
《Chinese Science Bulletin》1993年第14期1216-1219,共4页金冬雁 曾庆 周园 徐荣辉 李玉英 侯云德 
Project supported by grants from the State Commission of Science;Technology for the "863" Project for the Research and Development of Biotechnology.
The human α-interferon(IFNα) is a group of proteins possessing activity to render cells resistant to viral infection. It is one of the most promising and well documented recombinant proteins used in biotherapy. A pr...
关键词：hepatitis B virus PRE-S2 PROTEIN HUMAN α2a-interferon fusion PROTEIN bifunctional molecule. 
STUDIES ON 2′-5′(A)_n SYNTHETASE AND ITS PHYSIOLOGICAL FUNCTION——PURIFICATION AND PROPERTIES OF 2′-5′(A)_n SYNTHETASE B FROM RABBIT RETICULOCYTES
《Chinese Science Bulletin》1987年第13期913-920,共8页周爱民 杨开宇 
Project supported by the Science Fund of Academia Sinica
2’-5’(A)_n synthetase is a key enzyme involved in the antiviral process established by interferon. Generally, this enzyme is induced by interferon. However, it is also found in large amounts in rabbit reticulocytes ...
关键词：INTERFERON ANTIVIRAL SYNTHETASE rabbit physiological exposed exogenous STUDIES ON 2 SEPHAROSE impossible 
INHIBITORY EFFECT OF POLY I:C AND 2′,5′-OLIGO (A) ON CYTOPLASMIC POLYHEDROSIS VIRUS OF SILKWORM, BOMBYX MORI L.
《Chinese Science Bulletin》1983年第5期687-690,共4页钟文彪 黄自然 卢蕴良 刘新垣 娄艳春 
One of the major diseases in sericulture is the mid gut polyhedrosis, in which the pathogen is the cytoplasmic polyhedrosis virus （CPV）. After the silkworm larvae had been fed or injected with Poly Ⅰ: C or 2′, 5′...
关键词：SILKWORM oligo LARVAE CYTOPLASMIC ANTIVIRAL BOMBYX MORI L OLIGO inhibit eventually PATHOGEN 
PROTECTING EFFECT OF pppA_(2')p_(5')A_(2')p_(5')A AGAINST VIRUS INFECTION
《Chinese Science Bulletin》1981年第9期850-853,共4页刘新垣 闻玉梅 娄艳春 楼惠珍 王德宝The Second Laboratory. Shanghai Institute of Biochemistry Academia Sinica 
Interferon (IF) has been reported to be capable of inhibiting virus replication, cell division and tumor growth. Therefore, it has attracted the attention of investigators throughout the world. However, the mechanism ...
关键词：INTERFERON inhibiting understood REPLICATION capable INTERFERON distilled RABBIT DEAE ANTIVIRAL 
TOXICITY AND CLINICAL STUDIES ON POLY (I)-POLY (C)
《Chinese Science Bulletin》1980年第1期66-69,共4页PIC Research Cooperation Group of Institute of Genetics, Academia Sinica, Weijing (Sodium Glutamate) Manufactory, Tianjin and Institute of Microbiology, Academia Sinica 
In 1967, the synthetic polyriboinosinic acid: polyribocytidylic acid comlex (PIC) was found by Field to be a potent inducer of interferons. PIC has an antiviral activity to a wide spectrum of viruses and a number of o...
关键词：ANTIVIRAL INDUCER POTENT INTERFERON WEIGHING alone routine Jiangsu sixty Tianjin 
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