云南高校图书馆联盟文献共享服务平台- SPHINGOSINE

SPHINGOSINE: 作品数：80被引量：236H指数：8; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：张翼肖琼尹大力徐美林王菁更多>>; 相关机构：北京协和医学院首都医科大学天津市胸科医院天津医科大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金广东省自然科学基金北京市自然科学基金国家重点基础研究发展计划更多>>

Approach to loss of response to advanced therapies in inflammatory bowel disease被引量：1: 《World Journal of Gastroenterology》2024年第22期2902-2919,共18页Nikil Vootukuru Abhinav Vasudevan; BACKGROUND Remarkable progress over the last decade has equipped clinicians with many options in the treatment of inflammatory bowel disease.Clinicians now have the unique opportunity to provide individualized treatme...; 关键词：Inflammatory bowel disease Ulcerative colitis CROHN BIOLOGICS Interleukin-12 and interleukin-23 inhibitors Alpha-beta7-integrin inhibitors Janus kinase inhibitors Sphingosine-1-phosphate receptor modulators

The contributions of bacteria metabolites to the development of hepatic encephalopathy: 《Liver Research》2023年第4期296-303,共8页Miranda Claire Gilbert Tahereh Setayesh Yu-Jui Yvonne Wan; the USA National Institutes of Health(NIH)R01CA222490.; Over 20%of mortality during acute liver failure is associated with the development of hepatic encephalopathy(HE).Thus,HE is a complication of acute liver failure with a broad spectrum of neuropsychiatric abnormalities...; 关键词：LIVER Gut-liver-brain axis Bile acids(BAs) Bile acid(BA)receptors Farnesoid X receptor(FXR) Takeda G protein-coupled receptor 5(TGR5) Sphingosine-1-phosphate receptor 2 (S1PR2) Brain

Unveiling the biological role of sphingosine-1-phosphate receptor modulators in inflammatory bowel diseases被引量：4: 《World Journal of Gastroenterology》2023年第1期110-125,共16页Evanthia Tourkochristou Athanasia Mouzaki Christos Triantos; Inflammatory bowel disease(IBD)is chronic inflammation of the gastrointestinal tract that has a high epidemiological prevalence worldwide.The increasing disease burden worldwide,lack of response to current biologic th...; 关键词：Inflammatory bowel disease Sphingosine-1-phosphate Intestinal inflammation T helper 1/T helper 17 Sphingosine 1 phosphate Modulators Immune responses

Sphingosine-1-phosphate signal transducer and activator of transcription 3 signaling pathway contributes to baicalein-mediated inhibition of dextran sulfate sodium-induced experimental colitis in mice被引量：6: 《Chinese Medical Journal》2020年第3期292-300,共9页Jing Yao Tao Liu Rui-Jiao Chen Jing Liang Jun Li Chuan-Gong Wang; This work was supported by the grants from the National Natural Science Foundation of China(Nos.81603143,21807041);Shandong Medical and Health Science and Technology Development Project(Nos.2017WS646,2017WS653);Teachers'Research Support Fund of Jining Medical University(No.JYFC2018KJ037);National Natural Science Foundation Breeding Programs of Jining Medical University(No.JYP201708).; Background:Baicalein has been shown to have anti-inflammatory and anti-tumor activities.However,the mechanisms underlying its anti-inflammatory effect on colitis remain unclear.Methods:A dextran sodium sulfate(DSS)-in...; 关键词：BAICALEIN COLITIS STAT3 SPHINGOSINE kinase 1

Sphingosine-1-phosphate signaling and the gut-liver axis in liver diseases被引量：4: 《Liver Research》2019年第1期19-24,共6页Eric K.Kwong Huiping Zhou; This work was supported by the USA National Institutes of Health(NIH)grants R01 DK104893 and R01DK-057543;VA Merit Award I01BX004033 and 1I01BX001390;Research Career Scientist Award(IK6BX004477)from the Department of Veterans Affairs.; The liver is the central organ involved in lipid metabolism and the gastrointestinal(GI)tract is responsible for nutrient absorption and partitioning.Obesity,dyslipidemia and metabolic disorders are of increasing publ...; 关键词：Sphingosine-1-phosphate(S1P) Sphingosine kinase 2(SphK2) Sphingosine-1-phosphate receptor 2 (S1PR2) Gut-liver axis Liver diseases

Regulation of bile acid receptor activity被引量：9: 《Liver Research》2018年第4期180-185,共6页Yu-Jui Yvonne Wan Lili Sheng; This study was supported by grants funded by the USA National Institutes of Health(NIH)U01CA179582 and R01 CA222490.; Many receptors can be activated by bile acids(BAs)and their derivatives.These include nuclear receptors farnesoid X receptor(FXR),pregnane X receptor(PXR),and vitamin D receptor(VDR),as well as membrane receptors Take...; 关键词：Bile acid receptor Farnesoid X receptor(FXR) G protein-coupled bile acid receptor Takeda G protein receptor 5(TGR5) Sphingosine-1-phosphate receptor 2 (S1PR2) ACETYLATION Methylation GLYCOSYLATION

Bile acids as global regulators of hepatic nutrient metabolism被引量：3: 《Liver Research》2017年第1期10-16,共7页Phillip B.Hylemon Kazuaki Takabe Mikhail Dozmorov Masayuki Nagahashi Huiping Zhou; This work was supported by the US National Institutes of Health(grants R01DK57543 and R01DK104893).; Bile acids(BA)are synthesized from cholesterol in the liver.They are essential for promotion of the absorption of lipids,cholesterol,and lipid-soluble vitamins from the intestines.BAs are hormones that regulate nutrie...; 关键词：Sphingosine-1-phosphate Sphingosine kinase 2 Sphingosine-1-phosphate receptor 2 Fatty liver EPIGENETICS

Inhibition of sphingosine kinase 1 ameliorates acute liver failure by reducing high-mobility group box 1 cytoplasmic translocation in liver cells被引量：6: 《World Journal of Gastroenterology》2015年第46期13055-13063,共9页Yan-Chang Lei Ling-Ling Yang Wen Li Pan Luo Pei-Fen Zheng; Supported by the National Natural Science Foundation of China;No.81160065; AIM: To determine the therapeutic potential of sphingosine kinase 1(Sphk1) inhibition and its underlying mechanism in a well-characterized mouse model of D-galactosamine(D-Gal N)/lipopolysaccharide(LPS)-induced acute ...; 关键词：Acute liver failure SPHINGOSINE KINASE 1 High-mobi

Sphingosine kinase 1 dependent protein kinase C-δ activation plays an important role in acute liver failure in mice被引量：1: 《World Journal of Gastroenterology》2015年第48期13438-13446,共9页Yan-Chang Lei Ling-Ling Yang Wen Li Pan Luo; Supported by The National Natural Science Foundation of China;No.81160065; AIM: To investigate the role of protein kinase C(PKC)-δ activation in the pathogenesis of acute liver failure(ALF) in a well-characterized mouse model of D-galactosamine(D-Gal N)/lipopolysaccharide(LPS)-induced ALF.M...; 关键词：ACUTE liver failure Protein KINASE C-δ SPHINGOSINE KINASE 1 NUCLEAR factor-κB

New drug delivery system for liver sinusoidal endothelial cells for ischemia-reperfusion injury被引量：2: 《World Journal of Gastroenterology》2015年第45期12778-12786,共9页Naoki Sano Takafumi Tamura Naoyuki Toriyabe Takeshi Nowatari Ken Nakayama Tomohito Tanoi Soichiro Murata Yu Sakurai Mamoru Hyodo Kiyoshi Fukunaga Hideyoshi Harashima Nobuhiro Ohkohchi; Supported by Ministry of Education;Culture;Sports;Science;and Technology of Japan;KAKENHI;No.23390319; AIM: To investigate the cytoprotective effects in hepatic ischemia-reperfusion injury, we developed a new formulation of hyaluronic acid(HA) and sphingosine 1-phophate.METHODS: We divided Sprague-Dawley rats into 4 gr...; 关键词：Hyaluronic ACID SPHINGOSINE 1-phosphate LIVER sinu

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