TETRAMETHYLPYRAZINE

作品数：58被引量：265H指数：9
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相关作者：文志斌贺石林何晓凡庄沛张婉玉更多>>
相关机构：中南大学齐鲁工业大学天津科技大学沈阳华泰药物研究所更多>>
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Tetramethylpyrazine and paeoniflorin combination(TMP-PF)alleviates atherosclerosis progress by reducing hyperlipemia and inhibiting plaque angiogenesis via the NR4A1/VEGFR2 pathway
《Food Science and Human Wellness》2024年第5期2642-2652,共11页Rong Yuan Qiqi Xin Weili Shi Yu Miao Zhengchuan Zhu Yahui Yuan Ying Chen Xiaoning Chen Sean Xiao Leng Keji Chen Weihong Cong 
supported by Fundamental Research Funds for the Central Public Welfare Research Institutes(ZZ11-061,ZZ14-YQ-007);the National Natural Science Foundation of China(82004193);CACMS Innovation Fund(CI 2021A00914);Irma and Paul Milstein Program for Senior Health of Milstein Medical Asian American Partnership Foundation。
Atherosclerosis remains a great threat to human health worldwide.Previous studies found that tetramethylpyrazine(TMP)and paeonifl orin(PF)combination(TMP-PF)exerts anti-atherosclerotic effects in vitro.However,whether...
关键词：ATHEROSCLEROSIS HYPERLIPEMIA ANGIOGENESIS Plaque stability Chinese medicine TETRAMETHYLPYRAZINE PAEONIFLORIN 
Tetramethylpyrazine and paeoniflorin combination(TMP-PF)inhibits angiogenesis in atherosclerosis via miR-126/VEGF/VEGFR2 signaling pathway被引量：1
《Journal of Future Foods》2024年第3期280-287,共8页Yahui Yuan Rong Yuan Qiqi Xin Yu Miao Ying Chen Rui Gao Weihong Cong 
supported by the National Natural Science Foundation of China(82004193);CACMS Innovation Fund(CI 2021A00914);the Fundamental Research Funds for the Central Public Welfare Research Institutes(ZZ14-YQ-007).
Angiogenesis in atherosclerosis(AS)promotes plaque destabilization.miR-126 has a significant role in angiogenesis.Tetramethylpyrazine(TMP)and paeoniflorin(PF)have anti-atherosclerotic effects.However,the miR-126-relat...
关键词：ATHEROSCLEROSIS ANGIOGENESIS TETRAMETHYLPYRAZINE PAEONIFLORIN miR-126/VEGF/VEGFR2 signaling pathway 
Research Progress on the Anti-Atherosclerotic Effect and Mechanism of Tetramethylpyrazine
《Journal of Clinical and Nursing Research》2024年第6期94-99,共6页Shengyang Gong Zheng Cao 
Atherosclerosis is a chronic vascular disease and the most common pathological change of cardiovascular disease.Its pathogenesis is closely related to inflammation,oxidative stress,lipid accumulation,and calcinosis.Te...
关键词：ATHEROSCLEROSIS Chinese medicine TETRAMETHYLPYRAZINE Mechanism of action Research progress 
Tetramethylpyrazine prevents liver fibrotic injury in mice by targeting hepatocyte-derived and mitochondrial DNA-enriched extracellular vesicles被引量：13
《Acta Pharmacologica Sinica》2022年第8期2026-2041,共16页Ya-jing Li Run-ping Liu Ming-ning Ding Qi Zheng Jian-zhi Wu Xiao-yong Xue Yi-qing Gu Bo-ning Ma Ya-jie Cai Shuo Li Sheng Lin Lu-yong Zhang Xiaojiaoyang Li 
supported by the Beijing Municipal Science&Technology Commission(Grant No.7212174 to XL);National Natural Science Foundation of China(Grant No.82004045 to XL);Beijing Nova Program of Science&Technology(Grant No.Z191100001119088 to XL,Grant No.Z201100006820025 to RL);the Young Talents Promotion Project of China Association of Traditional Chinese Medicine(Grant No.2020-QNRC2-01 to XL);Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(Grant No.ZYYCXTD-C-202006 to XL).
Liver fibrosis is the common consequence of almost all liver diseases and has become an urgent clinical problem without efficient therapies.Recent evidence has shown that hepatocytes-derived extracellular vesicles(EVs...
关键词：liver fibrosis TETRAMETHYLPYRAZINE CCL4 ACETAMINOPHEN extracellular vesicle intercellular communication mouse primary hepatocytes hepatic stellate cells 
Tetramethylpyrazine inhibits proliferation of colon cancer cells in vitro被引量：4
《World Journal of Clinical Cases》2021年第18期4542-4552,共11页Hua Li Yan-Xu Hou Yu Yang Qing-Qiang He Tian-Hua Gao Xiao-Feng Zhao Zhi-Bin Huo Shu-Bo Chen Deng-Xiang Liu 
BACKGROUND Colon cancer is one of the most common malignancies worldwide,and chemotherapy is a widely used strategy in colon cancer clinical therapy.However,chemotherapy resistance is a major cause of disease recurren...
关键词：TETRAMETHYLPYRAZINE Colon cancer Apoptosis Cell proliferation CHEMOTHERAPY Cell cycle 
Tetramethylpyrazine analogue T-006 promotes clearance of alpha-synuclein by enhancing proteasome activity in Parkinson disease models被引量：1
《中国药理学与毒理学杂志》2019年第9期658-659,共2页ZHOU He-feng SHAO Min GUO Bao-jian LI Chu-wen LU Yu-cong YANG Xuan-jun LI Sheng-nan LI Hai-tao ZHU Qi ZHONG Han-bing WANG Yu-qiang ZHANG Zai-jun LU Jia-hong LEE Ming-yuen Simon 
Science and Technology Development Fund(FDCT)of Macao SAR(069/2015/A2;134/2014/A3;062-2017-AIR);Research Committee,University of Macao(MYRG2015-00182-ICMS-QRCM;MYRG2015-00214-ICMSQRCM;MYRG139(Y1-L4)-ICMS12-LMY;and MYRG2016-00129-ICMS-QRCM)
OBJECTIVE To investigate the effects of T-006(tetramethylpyrazine derivative)in promotingα-Synuclein(α-Syn)degradation and evaluated the neuroprotective effects in cellular and animalα-Syn model of Parkinson diseas...
关键词：Α-SYNUCLEIN degradation LMP7 proteasome activity Parkinson disease 
Tetramethylpyrazine Improves Postoperative Tissue Adhesion: A Drug Repurposing被引量：10
《Chinese Journal of Integrative Medicine》2019年第7期554-560,共7页YAN Shuai YUE Yin-zi ZONG Yang ZENG Li 
Supported by the National Natural Science Foundation of China(No.81804098,81673982);Natural Science Foundation of Jiangsu Province(No.BK20180219);Young Talents in Jiangsu Province(No.QNRC2016255);Youth Project of Suzhou Traditional Chinese Medicine Hospital(No.YQN2016003)
Plants are known to possess plenty of pharmacological activities as a result of various phytoconstituents. Tetramethylpyrazine(TMP), one of the most widely used medicinal compound isolated from traditional Chinese her...
关键词：TETRAMETHYLPYRAZINE TISSUE ADHESION PHARMACOLOGICAL activity review 
Percutaneous absorption and brain distribution facilitation of borneol on tetramethylpyrazine in a microemulsion-based transdermal therapeutic system被引量：4
《Asian Journal of Pharmaceutical Sciences》2019年第3期305-312,共8页Xiaoge Hu Ning Cheng Jihui Zhao Xianghua Piao Yulu Yan Qibo Zhang Kuan Zhou Yongtai Zhang Nianping Feng 
supported by the Program from Shanghai Uni-versity of Traditional Chinese Medicine(B201725)
In this study, we show that the percutaneous absorption and brain distribution of tetramethylpyrazine(TMP) is enhanced when combined with borneol(BN) in a microemulsionbased transdermal therapeutic system(ME-TTS). The...
关键词：TETRAMETHYLPYRAZINE BORNEOL MICROEMULSION PERCUTANEOUS absorption Brain distribution 
Intra-articular delivery of tetramethylpyrazine microspheres with enhanced articular cavity retention for treating osteoarthritis被引量：7
《Asian Journal of Pharmaceutical Sciences》2018年第3期229-238,共10页Xiuping Zhang Yang Shi Zhiyue Zhang Zhenlei Yang Guihua Huang 
Tetramethylpyrazine(TMP) is a traditional Chinese herbal medicine with strong antiinflammatory and cartilage protection activities, and thus a promising candidate for treating osteoarthritis. However, TMP is rapidly c...
关键词：OSTEOARTHRITIS TETRAMETHYLPYRAZINE INTRA-ARTICULAR injection PLGA MICROSPHERES RETENTION PHARMACODYNAMICS 
Synergistic Effects of Chuanxiong-Chishao Herb-Pair on Promoting Angiogenesis at Network Pharmacological and Pharmacodynamic Levels被引量：20
《Chinese Journal of Integrative Medicine》2017年第9期654-662,共9页WANG Yan GUO Gang YANG Bin-rui XIN Qi-qi LIAO Qi-wen LEE Simon Ming-Yuen HU Yuan-jia CHEN Ke-ji CONG Wei-hong 
Supported by Beijing Municipal Science and Technology Commission(No.Z141100002214011);the Science and Technology Development Fund of Macao SAR(No.069/2015/A2 and 134/2014/A3);Research Committee of University of Macao(No.MYRG2015-00182-ICMS-QRCM,MYRG2015-00214-ICMS-QRCM,MYRG139(Y1-L4)-ICMS12-LMY,and MYRG2016-00129-ICMS-QRCM),China
Objective： To investigate the synergistic effects of Chuanxiong-Chishao herb-pair （CCHP） on promoting angiogenesis in silico and in vivo. Methods： The mechanisms of action of an herb-pair, Chuanxiong- Chishao, wer...
关键词：TETRAMETHYLPYRAZINE paeoniflorin angiogenesis network pharmacology 
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