NEUREGULIN

作品数：28被引量：52H指数：3
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相关领域：医药卫生更多>>
相关作者：李江梅林王秋萍张磊陈超更多>>
相关机构：中国科学院上海生命科学研究院四川大学阿拉巴马大学苏州大学更多>>
相关期刊：《临床心血管病杂志》《Journal of Traditional Chinese Medicine》《中国糖尿病杂志》《分析测试学报》更多>>
相关基金：国家教育部博士点基金国家自然科学基金北京市自然科学基金河南省科技攻关计划更多>>
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The journey towards physiology and pathology: Tracing the path of neuregulin 4被引量：1
《Genes & Diseases》2024年第2期687-700,共14页Min Chen Jieying Zhu Hongyang Luo Wangjing Mu Liang Guo 
supported by The Program for Overseas Highlevel Talents at Shanghai Institutions of Higher Learning(China)(No.2022100 to L.G.);the National Natural Science Foundation of China(No.32070751 and 31871435 to L.G.).
Neuregulin 4 (Nrg4),an epidermal growth factor (EGF) family member,can bind to and activate the ErbB4 receptor tyrosine kinase.Nrg4 has five different isoforms by alternative splicing and performs a wide variety of fu...
关键词：ANGIOGENESIS Cardiovascular diseases Inflammation Insulin resistance Lipid and glucose metabolism NAFLD Neurobiogenesis Obesity 
SIBP-03, a novel anti-HER3 antibody, exerts antitumor effects and synergizes with EGFR- and HER2-targeted drugs
《Acta Pharmacologica Sinica》2024年第4期857-866,共10页Wen-jing Li Cheng-ying Xie Xi Zhu Jiao Tang Lei Wang Li-guang Lou 
supported by grants from the Science and Technology Commission of Shanghai Municipality(No 18DZ2293200);the Yunnan Province Sciences and Technology plan(No 202102AA310026).
HER3 (human epidermal growth factor receptor 3) acts through heterodimerization with EGFR (epidermal growth factor receptor) or HER2 to play an essential role in activating phosphoinositide 3-kinase (PI3K) and AKT sig...
关键词：SIBP-03 HER3 HER3-targeted therapy neuregulin 1 EGFR HER2 
老年缺血性脑卒中患者血清Egr-1、Neuregulin 1表达水平对血管性痴呆的预测效能被引量：6
《国际检验医学杂志》2023年第19期2385-2389,共5页涂艳 王丽平 
2019年国家社科基金后期资助项目(19FRKB002)。
目的分析老年缺血性脑卒中患者血清早期生长反应因子1(Egr-1)、神经调节蛋白1(NRG1)表达水平对血管性痴呆(VD)的预测效能。方法将2019年5月至2022年3月该院收治的122例老年缺血性脑卒中患者作为研究对象,随后根据治疗后6个月内是否发生...
关键词：缺血性脑卒中 血管性痴呆 早期生长反应因子1 神经调节蛋白1 
Chitosan conduits enriched with fibrin-collagen hydrogel with or without adipose-derived mesenchymal stem cells for the repair of 15-mm-long sciatic nerve defect被引量：2
《Neural Regeneration Research》2023年第6期1378-1385,共8页Marwa El Soury óscar Darío García-García Isabella Tarulli Jesús Chato-Astrain Isabelle Perroteau Stefano Geuna Stefania Raimondo Giovanna Gambarotia Víctor Carriel 
funded by the Spanish “Plan Nacional de Investigación Científica, Desarrollo e Innovación Tecnológica, Ministerio de Economía y Competitividad (Instituto de Salud Carlos Ⅲ),grants Nos. FIS PI14-1343, FIS PI17-0393, and FIS PI20-0318 co-financed by the “Fondo Europeo de Desarrollo Regional ERDF-FEDER European Union”;grant No. P18-RT-5059 by “Plan Andaluz de Investigación, Desarrollo e Innovación (PAIDI 2020),Consejería de Transformación Económica, Industria, Conocimiento y Universidades, Junta de Andalucía, España”;grant No. A-CTS-498-UGR18 by “Programa Operativo FEDER Andalucía 2014–2020, Universidad de Granada, Junta de Andalucía, España”, co-funded by ERDF-FEDER, the European Union (all to VC)
Hollow conduits of natural or synthetic origins have shown acceptable regeneration results in short nerve gap repair;however,results are still not comparable with the current gold standard technique“autografts”.Holl...
关键词：adipose-derived stem cells chitosan conduit fibrin and collagen hydrogel nerve regeneration nerve repair neuregulin 1 peripheral nerve sciatic nerve 
Changes in nitric oxide,angiotensinⅡ,angiopoietin-like protein 4 mRNA,neuregulin 1 mRNA,and platelet endothelial cell adhesion molecule-1 in rats with acute blood stasis induced by high-molecular-weight dextran被引量：3
《Journal of Traditional Chinese Medicine》2017年第6期846-853,共8页Feng Yu Zhang Junxiu Li Shaodan Liu Yi Zhang Yin Guo Yunxia Yang Minghui 
Supported by the National Program on Key Basic Research Project(973 Program:Study of Choroid Theory Based On Cardiac Cerebrovascular Disease.No.2012CB518601)
OBJECTIVE: To investigate the influence of acute blood stasis on nitric oxide(NO), angiotensin Ⅱ(Ang Ⅱ), angiopoietin-like protein 4(ANGPTL4)m RNA, neuregulin 1(NRG-1) m RNA, and platelet endothelial cell adhesion m...
关键词：Blood stasis Basic theory of TraditionalChinese Medicine Endothelial cells ANGIOTENSIN Ⅱ  NEUREGULIN-1 Antigens  CD31 
血清Neuregulin 4水平与2型糖尿病患者颈动脉内-中膜厚度的相关性研究被引量：7
《中国糖尿病杂志》2017年第11期985-988,共4页陈超 张磊 王秋萍 成兴波 
目的探讨血清脂肪因子Neuregulin 4(Nrg4)水平与T2DM患者颈动脉内-中膜厚度(CIMT)的关系。方法选择T2DM患者85例,颈动脉彩色超声测定CIMT,CIMT<0.9 mm为CIMT正常组(n=39),CIMT>0.9 mm为CIMT增厚组(n=46),另选健康对照(NC)组(n=44)。ELIS...
关键词：糖尿病 2型 脂肪因子 NEUREGULIN 4 颈动脉内-中膜厚度 
The recovery effect of neuregulin on the sciatic nerve constriction injury as well as its molecular mechanism
《Journal of Hainan Medical University》2017年第8期14-17,共4页Xin-Jun Wu Fei Xiang Hong Mu 
Youth Science Foundation No:2016D01c095.
Objective:To study the recovery effect of neuregulin (Nrg-1) on the sciatic nerve constriction injury as well as the expression of Nrg-1 downstream signaling molecules in sciatic nerve tissue.Methods: SD rats were sel...
关键词：NEUREGULIN SCIATIC nerve CONSTRICTION FIBROSIS PI3K Akt 
轴突信号Neuregulin 1在施旺细胞发育及再生修复中的作用被引量：3
《组织工程与重建外科杂志》2017年第1期45-47,共3页郑亚妮 张志英 
国家自然科学基金(81271396)
神经元轴突与施旺细胞(Schwann cells,SC)的相互接触和信号交流,在周围神经发育早期及其损伤后的修复、再生过程中,均具有极其重要的作用。在发育早期,神经元轴突对SC的增殖、迁移、分化和髓鞘化起着决定性作用。神经损伤后,沃勒变性使...
关键词：NEUREGULIN 1 施旺细胞 发育 再生 
Effects of epinephrine on angiogenesis-related gene expressions in cultured rat cardiomyocytes被引量：1
《The Journal of Biomedical Research》2016年第5期380-385,共6页Henry Liu Lisa Sangkum Geoffrey Liu Michael Green Marilyn Li Alan Kaye 
supported by internal funding from the Department of Anesthesiology and Perioperative Medicine
Epinephrine is often used for the treatment of patients with heart failure, low cardiac output and cardiac arrest. It can acutely improve hemodynamic parameters; however, it does not seem to improve longer term clinic...
关键词：EPINEPHRINE ANGIOGENESIS gene expression CARDIOMYOCYTES ANGIOPOIETIN-2 neuregulin 1 plasminogen activator inhibitor-1 SPARC-related modular calcium-binding protein 
神经调节蛋白1与周围神经疾病的研究进展被引量：2
《神经疾病与精神卫生》2015年第4期410-412,共3页张慧慧 孙艳艳 李国忠 钟镝 
黑龙江省教育厅基金项目（12521190）;国家卫生计生委重点临床专科建设项目-哈医大一院神经内科
神经调节蛋白1（NRG1）是一类含有表皮生长因子样结构域的营养因子，通过与表皮生长因子受体ErbB结合，激活下游信号系统，调控施万细胞分化、增殖和迁移，参与炎症性脱髓鞘、糖尿病周围神经病、轴索变性等多种周围神经疾病的演变和损...
关键词：神经调节蛋白1 周围神经疾病 髓鞘形成 综述文献 NEUREGULIN 1 
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