OLIGONUCLEOTIDES

作品数：75被引量：205H指数：6
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  • 期刊=World Journal of Gastroenterologyx
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Clusterin:Review of research progress and looking ahead to direction in hepatocellular carcinoma被引量：16
《World Journal of Gastroenterology》2015年第27期8262-8270,共9页Peng Xiu Xiao-Feng Dong Xin-Ping Li Jie Li 
Supported by National Nature Science Foundation of China,No.81172331 and No.30972890;Shandong Provincial Medicine and Health Science Technology Development Planning,China,No.2013WS0145
Liver cancer, a large proportion of which is hepatocellular carcinoma(HCC), is diagnosed in more than 700000 people each year worldwide. Liver cancer is particularly prevalent in Asia, Sub-Saharan Africa and the South...
关键词：HEPATOCELLULAR carcinoma CLUSTERIN Custirsen Chemotherapy ANTISENSE OLIGONUCLEOTIDES 
Depletion of telomerase RNA inhibits growth of gastrointestinal tumors transplanted in mice
《World Journal of Gastroenterology》2013年第15期2340-2347,共8页Xue-Cheng Sun Jing-Yi Yan Xiao-Lei Chen Ying-Peng Huang Xian Shen Xiao-Hua Ye 
Supported by The Natural Science Foundation of Zhejiang Province, No. Y201016273
AIM: To explore effects of telomerase RNA-targeting phosphorothioate antisense oligodeoxynucleotides (PS-ASODN) on growth of human gastrointestinal stromal tumors transplanted in mice. METHODS: A SCID mouse model for ...
关键词：Gastrointestinal stromal TUMOR PHOSPHOROTHIOATE antisense OLIGONUCLEOTIDES IMATINIB TUMOR inhibitory rate TELOMERASE activity 
Role of Smad7 in inflammatory bowel diseases被引量：1
《World Journal of Gastroenterology》2012年第40期5664-5668,共5页Giovanni Monteleone Roberta Caruso Francesco Pallone 
Supported by The Fondazione "Umberto di Mario" Onlus, Rome;the Broad Medical Research Foundation,No.IBD0301R;Giuliani SpA,Milan,Italy
Crohn's disease and ulcerative colitis,the major forms of inflammatory bowel diseases(IBD) in man,are complex diseases in which genetic and environmental factors interact to promote an excessive mucosal immune respons...
关键词：Inflammatory bowel diseases Gut inflam-mation Transforming growth factor-β1 SMAD7 Anti-sense oligonucleotides 
Intrahepatic expression of genes related to metabotropic receptors in chronic hepatitis被引量：2
《World Journal of Gastroenterology》2012年第31期4156-4161,共6页Andrzej Ciesla Maciej Kusmider Agata Faron-Górecka Marta Dziedzicka-Wasylewska Monika Bocisga-Jasik Danuta Owczarek Irena Cieko-Michalska Dorota Cibor Tomasz Mach 
AIM： To screen for genes related to metabotropic re- ceptors that might be involved in the development of chronic hepatitis. METHODS： Assessment of 20 genes associated with metabotropic receptors was performed in li...
关键词：Metabotropic receptors Gene expression DNA oligonucleotides Quantitative real-time poly-merase chain reaction Chronic hepatitis 
Expression of heparanase mRNA in anti-sense oligonucleotide-transfected human esophageal cancer EC9706 cells被引量：4
《World Journal of Gastroenterology》2005年第31期4916-4917,共2页Kui-Sheng Chen Lan Zhang Lin Tang Yun-Han Zhang Dong-Ling Gao Liang Yan Lei Zhang 
Supported by the Natural Science Foundation of Henan Province,No. 0311043700the Foundation for Young Mainstay Teachers in Colleges and universities of Henan Province, No.100(2003)the Building Foundation for 211 Key Fields during the 15th Five-year Plan Period of Ministry of Education, No. 2(2002)
AIM： To investigate the effed3 of anti-sense oligonucleotides （ASODNs） on mRNA expression of heparanase in human esophageal cancer EC9706 cells. METHODS： One non-sense oligonucleotide （N-ODN） and five ASODNs aga...
关键词：Esophageal cancer EC9706 cells HEPARANASE Anti-sense oligonucleotides In situ hybridization 
Inhibiting effect of antisense oligonucleotides phosphorthioate on gene expression of TIMP-1 in rat liver fibrosis被引量：73
《World Journal of Gastroenterology》2001年第3期363-369,共7页Qing He Nie Yong Qian Cheng Yu Mei Xie Yong Xing Zhou Yi Zhan Cao The Center of Infectious Disease Diagnosis and Treatment of PLA,Tangdu Hospital,Forth Military Medical University,Xi’an 710038,Shaanxi Province,ChinaDr,Qing He Nie graduated from Qinghai Medical College as a doctor in 1983,got master degree at Beijing 302 Army Hospital in 1993,got doctor degree at the Third Military Medical University in 1998,engaged in postdoctoral research at the Fourth Military Medical University from 1998 to 2000,now an associate professor,specialized in clinical and experimental research of infectious diseases,had more than 90 papers published,coauthor of ten books,first author of one book. 
Supported by the Postdoctoral Science Foundation of China(No.1999-10 State Postdoctoral Foundation Commission)
AIM: To observe the inhibition of antisense oligonucleotides (asON) phosphorthioate to the tissue inhibitors metalloproteinase-1 (TIMP-1) gene and protein expression in the liver tissue of immunologically induced hepa...
关键词：Gene Therapy Animals Collagen Type I Collagen Type III Disease Models  Animal Female Gene Expression Hepatocytes Immunohistochemistry Liver Liver Cirrhosis Microscopy  Electron Oligonucleotides  Antisense PROCOLLAGEN RNA  Messenger RATS Rats  Wistar Research Support  Non-U.S. Gov't Tissue Inhibitor of Metalloproteinase-1 
Inhibitory effects of EGFR antisense oligodeoxynucleotide in human colorectal cancer cell line被引量：5
《World Journal of Gastroenterology》2000年第5期747-749,共3页Yong He Jun Zhou Jin Sheng Wu Ke Feng Dou 
INTRODUCTIONEpidermal-growth-factor receptor(EGFR) is apolypeptide with 1186 amino acids,which binds toEGF family growth factors.Two major naturalligands in the family interact with EGFR:one isEGF,the other is transfo...
关键词：colorectal neoplasms OLIGONUCLEOTIDES ANTISENSE EPIDERMAL growth factor receptor gene therapy liposomes flow CYTOMETRY 
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