PEPTIDE

作品数：1070被引量：2052H指数：15
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Signaling profiles in HEK 293T cells co-expressing GLP-1 and GIP receptors
《Acta Pharmacologica Sinica》2022年第6期1453-1460,共8页Yu-zhe Wang De-hua Yang Ming-wei Wang 
This work was partially supported by National Natural Science Foundation of China 81872915(MWW),82073904(MWW),81773792(DHY)and 81973373(DHY);National Science and Technology Major Project of China–Key New Drug Creation and Manufacturing Program 2018ZX09735–001(MWW)and 2018ZX09711002–002–005(DHY);the National Key Basic Research Program of China 2018YFA0507000(MWW);Novo Nordisk-CAS Research Fund grant NNCAS-2017–1-CC(DHY);SA-SIBS Scholarship Program(DHY).
Glucagon-like peptide-1(GLP-1)and glucose-dependent insulinotropic polypeptide(GIP)are regarded as‘incretins’working closely to regulate glucose homeostasis.Unimolecular dual and triple agonists of GLP-1R and GIPR h...
关键词：glucagon-like peptide-1 receptor glucose-dependent insulinotropic peptide receptor peptide 19 LY3298176 heteromerization type 2 diabetes 
Solution structure of the voltage-gated Tim23 channel in complex with a mitochondrial presequence peptide
《Cell Research》2021年第7期821-824,共4页Shu Zhou Maosen Ruan Yunyan Li Jing Yang Suwen Bai Christian Richter Harald Schwalbe Can Xie Bing Shen Junfeng Wang 
supported by the High Magnetic Field Laboratory of Anhui Province;This study was supported by grants from the Ministry of Science and Technology of China(Grant No.,2016YFA0400901);the National Natural Science Foundation of China(Grant No.,U1632274);Hefei Science Center of Chinese Academy of Sciences(Grant No.,2020HSC-CIP011);by iNEXT-Discovery,project number 871037,funded by the Horizon 2020 program of the European Commission.
Dear Editor,Most mitochondrial proteins are synthesized in the cytosol and transported into various mitochondrial subcompartments in a process that is mediated by intricate multimeric machineries.Tim23,the key compone...
关键词：SEQUENCE CONDUCTING structure 
Signal transducer and activator of transcription is involved in the expression regulation of ecdysteroid-induced insulin-like growth factor-like peptide in the pupal wing disc of silkworm, Bombyx mori
《Insect Science》2020年第6期1186-1197,共12页Xiao-Juan Zhang Dong-Dong Li Guan-Feng Xu Ya-Qing Chen Si-Chun Zheng 
the National Basic Research Program of China(No.282012CB114603);the Scientific Research Cultivation Fund for Young Faculty of South China Normal University(Grant No.15KJ08).
In insects,20-hydroxyecdysone(20E)and insulin-like growth factor-like peptides(IGFLPs)regulate the development o f imaginal discs.However,how IGFLPs are up-regulated to impact the development of the pupal wing disc is...
关键词：Bombyx mori expression regulation IGFLP 20-HYDROXYECDYSONE STAT 
Targeting peptide-decorated biomimetic lipoproteins improve deep penetration and cancer cells accessibility in solid tumor被引量：5
《Acta Pharmaceutica Sinica B》2020年第3期529-545,共17页Tao Tan Yuqi Wang Jing Wang Zhiwan Wang Hong Wang Haiqiang Cao Jie Li Yaping Li Zhiwen Zhang Siling Wang 
financially supported by the National Basic Research Program of China(2015CB932103);the National Natural Science Foundation of China(31771092,81521005,81690265);the Youth Innovation Promotion Association of Chinese Academy of Sciences and Fudan-SIMM Joint Research Fund(FU-SIMM20182005,China).
The limited penetration of nanoparticles and their poor accessibility to cancer cell fractions in tumor remain essential challenges for effective anticancer therapy.Herein,we designed a targeting peptide-decorated bio...
关键词：LIPOPROTEIN Drug delivery Tumor penetration Nanoparticles Cancer therapy 
In vitro leishmanicidal activity of antimicrobial peptide KDEL against Leishmania tarentolae
《Acta Biochimica et Biophysica Sinica》2019年第12期1286-1292,共7页Lili Cao Weina Jiang Songgao Cao Panpan Zhao Juan Liu Hang Dong Yanbing Guo Quan Liu Pengtao Gong 
This work was supported by the grants from the National Natural Science Foundation of China(Nos.31672288,31302076,and 31001057);the National Science and Technology Major Project of the Ministry of Science and Technology of China(No.2012ZX09103301-021);the National Key Technology R&D program(No.2015BAI07B02);China Postdoctoral Science Foundation(No.2014 M552636).
Leishmaniasis,caused by the intracellular protozoan parasite Leishmania,remains an important neglected tropical infectious disease.Infection may be lethal if untreated.Currently,the available drugs for the disease are...
关键词：ANTIMICROBIAL PEPTIDE KDEL LEISHMANIA xarento\ae LEISHMANIASIS 
Anti-cyclic citrullinated peptide antibody predicts the development of rheumatoid arthritis in patients with undifferentiated arthritis被引量：6
《Chinese Medical Journal》2019年第24期2899-2904,共6页Chun Li Yan Zhang Hui Song Jie Gao Dong-Bao Zhao Qi Zhu Dong-Yi He Li Wang Xiang-Pei Li Xu-Dong Liu Wei-Guo Xiao Xin-Yu Wu Hua-Xiang Wu Wei Tu Shao-Xian Hu Xin Wang Zhi-Jun Li Zhi-Min Lu Zhan-Yun Da Bo Liang Xiao-Min Liu Jin-Wei Zhao Ling Li Feng Han Wu-Fang Qi Wei Wei Xu Ma Zhen-Bin Li Gui-Min Zheng Feng-Xiao Zhang Yi Li You-Lian Wang Guang-Hui Ling Jin-Wei Chen Xiao-Qiang Hou Jing Zhang Qing-Ping Chen Chang-Lian Liu Yan Zhang Jia-Shun Zeng Qing-Hua Zou Yong-Fei Fang Yin Su Zhan-Guo Li 
The study was supported by the grants from the Ministry of Science and Technology of China(No.2008BAI59800 and 2014BAI07B01);the National Natural Science Foundation of China(No.81671609);Beijing Municipal Science and Technology Project(No.Z171100000417007).
Background:Clinical outcomes of undifferentiated arthritis(UA)are diverse,and only 40%of patients with UA develop rheumatoid arthritis(RA)after 3 years.Discovering predictive markers at disease onset for further inter...
关键词：Anti-cyclic citrullinated PEPTIDE ANTIBODY Arthritis Rheumatoid RHEUMATOID factor UNDIFFERENTIATED ARTHRITIS 
CLE25 peptide regulates phloem initiation in Arabidopsis through a CLERK-CLV2 receptor complex被引量：13
《Journal of Integrative Plant Biology》2019年第10期1043-1061,共19页Shi-Chao Ren Xiu-Fen Song Wen-Qiang Chen Ran Lu William J. Lucas Chun-Ming Liu 
provided by the Ministry of Science and Technology of China (2014CB943400);the National Natural Science Foundation of China (31370029; 31871455);the Youth Innovation Promotion Association of the Chinese Academy of Sciences
The phloem, located within the vascular system, is critical for delivery of nutrients and signaling molecules throughout the plant body. Although the morphological process and several factors regulating phloem differe...
关键词：CLE25 PEPTIDE CLERK-CLV2 RECEPTOR complex 
Kinetically Controlled Carboxypeptidase-Catalyzed Synthesis of Novel Antioxidant Dipeptide Precursor BOC-Tyr-Ala
《Transactions of Tianjin University》2018年第6期513-521,共9页Yuyao Shan Wei Qi Mengfan Wang Rongxin Su Zhimin He 
supported by Ministry of Science and Technology of China(No.2012YQ090194 and No.2013AA102204);the National Natural Science Foundation of China(No.21676191,No.21476165,and No.21621004)
Recently, enzymatic peptide synthesis has drawn increasing attention due to its eco-friendly reagents and mild conditions, as compared to traditional chemical peptide synthesis. In this study, we successfully produced...
关键词：Antioxidant dipeptide precursor Kinetic control Reaction kinetic model Enzymatic peptide synthesis 
Mechanical-force-promoted peptide assembly: a general method
《Nuclear Science and Techniques》2018年第9期192-196,共5页Yue Yuan Qi-Qi-Ge Du Yu-Jiao Wang Jun Hu Shi-Tao Lou Yi Zhang 
supported by the National Natural Science Foundation of China(No.11674344);the National Basic Research Program of China(973 program,No.2013CB932801);the Key Research Program of Frontier Sciences,Chinese Academy of Sciences(No.QYZDJ-SSW-SLH019-2)
A general method was developed for promoting peptide assembly and protein polymerization to form nanoscale patterns on various surfaces with an atomic force microscope(AFM) operated in a liquid. By scanning solid surf...
关键词：Self-assembly PEPTIDE Nanomechanical STIMULUS Support LIPID BILAYERS Atomic FORCE MICROSCOPE 
Study on the regulation of brain-gut peptide by Shenling Baizhu San in functional diarrhea rats被引量：3
《Journal of Traditional Chinese Medical Sciences》2018年第3期283-290,共8页Yuan Li Weiyue Zhang Jie Ma Mindan Chen Bingqi Lin Xi Yang Feng Li Xudong Tang Fengyun Wang 
Objective:To explore the therapeutic mechanism of Shenling Baizhu San (SLBZS) on functional diarrhea (FDr) by studying the brain-gut axis and related neuropeptides.Methods:Sixty male Wistar rats were randomly divided ...
关键词：Shenling Baizhu SAN Functional DIARRHEA Brain-gut AXIS Brain-gut PEPTIDE 
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