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作品数：1229被引量：1986H指数：18
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相关机构：中国科学技术大学四川大学同济大学附属同济医院浙江省人民医院更多>>
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  • 期刊=Signal Transduction and Targeted Therapyx
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Macrophages promote pre-metastatic niche formation of breast cancer through aryl hydrocarbon receptor activity
《Signal Transduction and Targeted Therapy》2025年第1期369-383,共15页Xu Jiang Jiaqi Wang Liangyu Lin Liming Du Yayun Ding Fanjun Zheng Hongzhen Xie Yu Wang Mingyuan Hu Benming Liu Muhan Xu Jingjie Zhai Xuefeng Wang Jiayin Ye Wei Cao Chao Feng Jingyi Feng Zongliu Hou Mingyao Meng Ju Qiu Qing Li Yufang Shi Ying Wang 
support for the research of this work from the National Key R&D Program of China(2022YFA0807300);National Natural Science Foundation of China(82425032,32070872,31771641);Y.S.discloses support for the research of this work from National Natural Science Foundation of China(82430086,81930085);L.L.discloses support for the research of this work from the National Natural Science Foundation of China(82470658);a Fellowship of China Postdoctoral Science Foundation(2020M671261);Q.L.discloses support for the research of this work from the National Natural Science Foundation of China(82301571).
Macrophages that acquire an immunosuppressive phenotype play a crucial role in establishing the pre-metastatic niche (PMN),which is essential for facilitating breast cancer metastasis to distant organs. Our study show...
关键词：BREAST METASTATIC METASTASIS 
Corynebacterium parakroppenstedtii secretes a novel glycolipid to promote the development of granulomatous lobular mastitis
《Signal Transduction and Targeted Therapy》2024年第11期5250-5266,共17页Ran Liu Zixuan Luo Chong Dai Yuchen Wei Shuqing Yan Xinwen Kuang Kuan Qi Aisi Fu Yinxin Li Shuai Fu Zhengning Ma Wen Dai Xiao Xiao Qing Wu Haokui Zhou Yan Rao Jingping Yuan Ting Shi Zixin Deng Chuang Chen Tiangang Liu 
supported by the National Key Research and Development Program of China(2018YFA0900400 to T.L.);Leading Talents of the Ten Thousand Talents Program to T.L.,Young Elite Scientists Sponsorship Program by China Association for Science and Technology to R.L.,the Shenzhen Institute of Synthetic Biology Scientific Research Program(Z.X.and R.L.);funding from State Key Laboratory of Microbial Metabolism,Shanghai Jiao Tong University(MMLZD24-01);the grants from The Interdisciplinary Innovative Talents Foundation from Renmin Hospital of Wuhan University(JCRCFZ-2022-015)to C.C.;the Fundamental Research Funds for the Central Universities(2042019kf0229)to C.C.;the Natural Science Foundation of Hubei Province(2023AFB701)to C.C.
Granulomatous lobular mastitis(GLM)is a chronic idiopathic granulomatous mastitis of the mammary gland characterized by significant pain and a high propensity for recurrence,the incidence rate has gradually increased,...
关键词：PREVENTION DIAGNOSIS TREATMENT 
Histone deacetylase inhibition enhances extracellular vesicles from muscle to promote osteogenesis via miR-873-3p
《Signal Transduction and Targeted Therapy》2024年第10期4730-4748,共19页Ming Chen Yi Li Mingming Zhang Siliang Ge Taojin Feng Ruijing Chen Junmin Shen Ran Li Zhongqi Wang Yong Xie Duanyang Wang Jiang Liu Yuan Lin Feifan Chang Junyu Chen Xinyu Sun Dongliang Cheng Xiang Huang Fanfeng Wu Qinxiang Zhang Pingqiang Cai Pengbin Yin Licheng Zhang Peifu Tang 
National Natural Science Foundation of China(82002330,81972115,82202728);National Key Research and Development Program of China(2022YFC2504300);Beijing Municipal Natural Science Foundation(2022HQ27).
Regular physical activity is widely recognized for reducing the risk of various disorders,with skeletal muscles playing a key role by releasing biomolecules that benefit multiple organs and tissues.However,many indivi...
关键词：ORGANS holds MUSCLE 
DNA of neutrophil extracellular traps promote NF-κBdependent autoimmunity via cGAS/TLR9 in chronic obstructive pulmonary disease被引量：2
《Signal Transduction and Targeted Therapy》2024年第7期3040-3055,共16页Jun Chen Tao Wang Xiaoou Li Lijuan Gao Ke Wang Mengxin Cheng Zijian Zeng Lei Chen Yongchun Shen Fuqiang Wen 
supported by the 1•3•5 project for disciplines of excellence,West China Hospital,Sichuan University[grant numbers ZYGD23009];the National Natural Science Foundation of China(NSFC)[grant numbers 81830001,81670038,81800015 and 31871157];the Natural Science Foundation of Sichuan Province[Grant number 2022NSFSC0603];the China Postdoctoral Science Foundation[Grant numbers 2019T120851 and 2018M643501];the Fundamental Research Funds for the Central Universities(the Postdoctoral Foundation of Sichuan University)[Grant number 2018SCU12028].
Chronic obstructive pulmonary disease(COPD)is characterised by persistent airway inflammation even after cigarette smoking cessation.Neutrophil extracellular traps(NETs)have been implicated in COPD severity and acute ...
关键词：INFLAMMATION TLR9 NEUTROPHIL 
METTL14 downregulation drives S100A4^(+)monocyte-derived macrophages via MyD88/NF-κB pathway to promote MAFLD progression被引量：1
《Signal Transduction and Targeted Therapy》2024年第5期2176-2192,共17页Yue-fan Wang Wen-li Zhang Zhi-xuan Li Yue Liu Jian Tan Hao-zan Yin Zhi-chao Zhang Xian-jie Piao Min-hao Ruan Zhi-hui Dai Si-jie Wang Chen-yang Mu Ji-hang Yuan Shu-han Sun Hui Liu Fu Yang 
This research was supported by grants from the National Key Research and Development Program of China(2023YFC2505900,2016YFC1302303);the National Natural Science Foundation of China(nos.81972657 and 81830085).
Without intervention,a considerable proportion of patients with metabolism‐associated fatty liver disease(MAFLD)will progress from simple steatosis to metabolism‐associated steatohepatitis(MASH),liver fibrosis,and e...
关键词：S100A4 MYD88 METABOLISM 
EZH2 inhibitors promote β-like cell regeneration in young and adult type 1 diabetes donors
《Signal Transduction and Targeted Therapy》2024年第2期679-692,共14页Keith Al-Hasani Safiya Naina Marikar Harikrishnan Kaipananickal Scott Maxwell Jun Okabe Ishant Khurana Thomas Karagiannis Julia J.Liang Lina Mariana Thomas Loudovaris Thomas Kay Assam El-Osta 
National Health and Medical Research Council(NHMRC)Senior Research Fellow(grant 1154650);acknowledges grant support from NHMRC Clinical Trials and Cohort Studies(grant 2014763);supported by a strategic research agreement by JDRF International grant(2-SRA-2024-1442-S-B);a research grant from the Danish Diabetes Academy to A.E.O.,which is funded by the Novo Nordisk Foundation,grant NNF17SA0031406.
β-cells are a type of endocrine cell found in pancreatic islets that synthesize,store and release insulin.In type 1 diabetes(T1D),T-cells of the immune system selectively destroy the insulin-producingβ-cells.Destruc...
关键词：EZH2 struction INHIBITORS 
SUMOylation-triggered ALIX activation modulates extracellular vesicles circTLCD4-RWDD3 to promote lymphatic metastasis of non-small cell lung cancer被引量：2
《Signal Transduction and Targeted Therapy》2023年第12期5887-5903,共17页Xiayao Diao Chao Guo Hanhao Zheng Ke Zhao Yuming Luo Mingjie An Yan Lin Jiancheng Chen Yuanlong Li Yuting Li Xuehan Gao Jiaqi Zhang Mengxin Zhou Wenliang Bai Lei Liu Guige Wang Lanjun Zhang Xiaotian He Rusi Zhang Zhihua Li Changhao Chen Shanqing Li 
funded by the National High Level Hospital Clinical Research Funding(Grant No.2022-PUMCH-B-011);the National Key Research and Development Program of China(Grant No.2022YFA1305500);the National Natural Science Foundation of China(Grant No.32322023,82173272,81825016,82173230,82341018,82203662,82173271,82103416,82103536,82173266,82202276,and 81972385);the Key Areas Research and Development Program of Guangdong(Grant No.2022B1515120086,2021B1515020091,2022A1515140175,2021A1515010215,2023A1515011648,2022A1515012288,2021A1515010355);the Science and Technology Program of Guangzhou,China(Grant No.2023A04J2206).
Lymph node(LN)metastasis is one of the predominant metastatic routes of non-small cell lung cancer(NSCLC)and is considered as a leading cause for the unsatisfactory prognosis of patients.Although lymphangiogenesis is ...
关键词：METASTASIS inhibited LYMPHATIC 
Correction: Eosinophils promote pulmonary matrix destruction and emphyysema via Cathepsin L
《Signal Transduction and Targeted Therapy》2023年第12期5970-5973,共4页
Eosinophils promote pulmonary matrix destruction and emphvsema via Cathepsin L被引量：5
《Signal Transduction and Targeted Therapy》2023年第11期5368-5382,共15页Xia Xu Tao Yu Lingling Dong Rainer Glauben Siyuan Wu Ronghua Huang Shiwei Qumu Chenli Chang Jing Guo Lin Pan Ting Yang Xin Lin Ke Huang Zhihua Chen Chen Wang 
the National Natural Science Foundation of China(81970036);the Natural Science Foundation of Beijing(7202130);the CAMS Innovation Fund for Medical Sciences(2021-12M-1-049 and 2022-12M-C&T-B-107).
Patients with chronic obstructive pulmonary disease(COPD)who exhibit elevated blood eosinophil levels often experience worsened lung function and more severe emphysema.This implies the potential involvement of eosinop...
关键词：lung INVOLVEMENT ELEVATED 
RPS15 interacted with IGF2BP1 to promote esophageal squamous cell carcinoma development via recognizing m^(6)A modification被引量：5
《Signal Transduction and Targeted Therapy》2023年第7期3400-3414,共15页Yahui Zhao Yang Li Rui Zhu Riyue Feng Heyang Cui Xiao Yu Furong Huang Ruixiang Zhang Xiankai Chen Lei Li Yinghui Chen Yuhao Liu Jinhua Wang Guanhua Du Zhihua Liu 
The authors are grateful to Dr.Zhi Lu(Tsinghua University,China)for kindly providing RNA-seq analysis and ribosome-seq analysis technique direction.The authors are grateful to Dr.Yutaka Shimada(Kyoto University,Japan)for the ESCC cell lines.The authors appreciate Cong Liu(Sinsage Technology Co.LTD)for providing the Livecyte single-cell tracking imaging analysis system.The authors thank Novogene Bioinformatics Technology Co.,Ltd.,Beijing,for assistance during the Ribosome-seq analysis.This work was supported by the National Natural Science Foundation of China(82188102,81903025,82273453 and 82030089);National Key R&D Program of China(2021YFC2501000 and 2020YFA0803300);CAMS Innovation Fund for Medical Sciences(2021-1-I2M-1-018,2022-I2M-2-001 and 2021-I2M-1-067);the Fundamental Research Funds for the Central Universities(3332021091).
Increased rates of ribosome biogenesis have been recognized as hallmarks of many cancers and are associated with poor prognosis.Using a CRISPR synergistic activation mediator(SAM)system library targeting 89 ribosomal ...
关键词：ESOPHAGEAL SQUAMOUS PROGNOSIS 
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