PROSTATE_CANCER

作品数：1256被引量：2510H指数：19
导出分析报告
相关作者：王增军邱实黄鹰段秀枝魏强更多>>
相关机构：浙江大学医学院附属第二医院江苏省人民医院复旦大学上海交通大学医学院附属第九人民医院更多>>
相关期刊：更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金北京市自然科学基金更多>>
-
在结果中检索

检索结果分析

结果分析中...
选择条件：
  • 学科=医药卫生—药学x
共 条 记 录，以下是1-10
全选清除导出
参考文献引证文献引用追踪
视图：
排序：
Talaketides A-G,linear polyketides with prostate cancer cytotoxic activity from the mangrove sediment-derived fungus Talaromyces sp.SCSIO 41027
《Chinese Journal of Natural Medicines》2024年第11期1047-1056,共10页CHEN Chunmei WANG Xueni FANG Wenxuan LIANG Jiaqi CAI Jian YANG Dehua LUO Xiaowei GAO Chenghai YI Xiangxi LIU Yonghong ZHOU Xuefeng 
supported by the Key-Area Research and Development Program of Guangdong Province(No.2023B1111050008);the National Natural Science Foundation of China(Nos.U23A20528,U20A20101);Guangdong Local Innovation Team Program(No.2019BT02Y262);the Postdoctoral Fellowship Program of CPSF(No.GZC20232777).
Seven novel linear polyketides,talaketides A-G(1-7),were isolated from the rice media cultures of the mangrove sed-iment-derived fungus Talaromyces sp.SCSIO 41027.Among these,talaketides A-E(1-5)represented unpreceden...
关键词：Mangrove sediment-derived fungus Talaromyces sp.Linear polyketides Cytotoxicity Prostate cancer 
Icariin plus curcumol enhances autophagy through the mTOR pathway and promotes cathepsin B-mediated pyroptosis of prostate cancer cells
《Asian Pacific Journal of Tropical Biomedicine》2024年第2期55-64,共10页Xu-Yun Wang Wen-Jing Xu Bo-Nan Li Tian-Song Sun Wen Sheng 
supported by Natural Science Foundation of Hunan Province(No.2023JJ40511);Excellent Youth Project of Scientific Research Program of Hunan Education Department(No.22B0370);Project of Traditional Chinese Medicine Administration of Hunan Province(No.B2023034);Science and Technology Development Foundation of Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University(No.LYYB202214);Hunan Provincial Hygiene and Health Commission Health Research Project(No.W20243165).
Objective:To examine the effect of icariin plus curcumol on prostate cancer cells PC3 and elucidate the underlying mechanisms.Methods:We employed the Cell Counting Kit 8 assay and colony formation assay to assess cell...
关键词：ICARIIN CURCUMOL AUTOPHAGY MTOR Cathepsin B PYROPTOSIS Prostate cancer 
Marsdenia tenacissima injection induces the apoptosis of prostate cancer by regulating the AKT/GSK3β/STAT3 signaling axis被引量：6
《Chinese Journal of Natural Medicines》2023年第2期113-126,共14页LI Xiaolan HE Songhua LIANG Wei ZHANG Weiquan CHEN Xin LI Qiaofeng YANG Xin LIU Yanying ZHU Dan LI Li LIU Buming SU Zhiheng CHEN Jie GUO Hongwei 
supported by the National Natural Science Foundation of China(No.82160948);Guangxi Natural Science Foundation(No.2022JJD140152);the Open Project of Guangxi Key Laboratory of Traditional Chinese Medicine Quality Standards(No.GUIZHONGZHONGKAI 202004)。
Marsdenia tenacissima injection,a standard Marsdenia tenacissima extract(MTE),has been approved as an adjuvant therapeutic agent for various cancers.Our previous study showed that MTE inhibited the proliferation and m...
关键词：Marsdenia tenacissima injection Prostate cancer APOPTOSIS AKT/GSK3β/STAT3 
Discovery of novel antagonists targeting the DNA binding domain of androgen receptor by integrated docking-based virtual screening and bioassays被引量：3
《Acta Pharmacologica Sinica》2022年第1期229-239,共11页Jin-ping Pang Chao Shen Wen-fang Zhou Yun-xia Wang Lu-hu Shan Xin Chai Ying Shao Xue-ping Hu Feng Zhu Dan-yan Zhu Li Xiao Lei Xu Xiao-hong Xu Dan Li Ting-jun Hou 
This study was supported by the Key R&D Program of Zhejiang Province(2020C03010),National Natural Science Foundation of China(81773632),Zhejiang Provincial Natural Science Foundation of China(LZ19H300001),and the Key R&D Program of Zhejiang Province(2019C02024).
Androgen receptor(AR),a ligand-activated transcription factor,is a master regulator in the development and progress of prostate cancer(PCa).A major challenge for the clinically used AR antagonists is the rapid emergen...
关键词：androgen receptor DNA binding domain ANTAGONIST prostate cancer virtual screening molecular docking 
Artemisia kruhsiana leaf extract induces autophagic cell death in human prostate cancer cells被引量：2
《Chinese Journal of Natural Medicines》2021年第2期134-142,共9页LEE Se-Eun SIVTSEVA Sardana LIM Chiyeon OKHLOPKOVA Zhanna CHO Suin 
Some species of Artemisia have been reported to induce apoptosis and autophagy,but little is known of the apoptotic and autophagic effects of the stems and leaves of Artemisia kruhsiana Bess.(AkB).This study was condu...
关键词：Artemisia kruhsiana PHARMACOGNOSY Prostate cancer AUTOPHAGY 
Dracocephalum palmatum Stephan extract induces apoptosis in human prostate cancer cells via the caspase-8-mediated extrinsic pathway被引量：2
《Chinese Journal of Natural Medicines》2020年第10期793-800,共8页LEE Se-Eun OKHLOPKOVA Zhanna LIM Chiyeon CHO Suin 
Dracocephalum palmatum Stephan is a medicinal plant traditionally used by nomadic people in Eastern Russia;however,research on this plant is currently limited.Recently,although studies have been conducted on the const...
关键词：Dracocephalum palmatum Stephan Prostate cancer APOPTOSIS CASPASE-8 
First small-molecule PROTACs for G protein-coupled receptors:inducing α1A-adrenergic receptor degradation被引量：4
《Acta Pharmaceutica Sinica B》2020年第9期1669-1679,共11页Zhenzhen Li Yuxing Lin Hui Song Xiaojun Qin Zhongxia Yu Zheng Zhang Gaopan Dong Xiang Li Xiaodong Shi Lupei Du Wei Zhao Minyong Li 
supported by grants from the National Natural Science Foundation of China(No.21629201);the Shandong Natural Science Foundation(No.ZR2018ZC0233,China);the Taishan Scholar Program at Shandong Province;the Qilu/Tang Scholar Program at Shandong University;the Major Project of Science and Technology of Shandong Province(No.2015ZDJS04001,China);the Key Research and Development Project of Shandong Province(No.2017CXGC1401,China)
Proteolysis targeting chimeras(PROTACs)are dual-functional hybrid molecules that can selectively recruit an E3 ubiquitin ligase to a target protein to direct the protein into the ubiquitinproteasome system(UPS),thereb...
关键词：Small-molecule PROTACs α1A-Adrenergic receptor UBIQUITYLATION DEGRADATION Prostate cancer 
Design of drug-like hepsin inhibitors against prostate cancer and kidney stones
《Acta Pharmaceutica Sinica B》2020年第7期1309-1320,共12页Vincent Blay Mu-Chun Li Sunita P.Ho Mashall L.Stoller Hsing-Pang Hsieh Douglas R.Houston 
the Scottish Funding Council;the University of Edinburgh
Hepsin,a transmembrane serine protease abundant in renal endothelial cells,is a promising therapeutic target against several cancers,particularly prostate cancer.It is involved in the release and polymerization of uro...
关键词：Virtual screening DOCKING LIBRARY HEPSIN Tamm-Horsfall protein BIOMINERALIZATION 
Synergistic effects of a curcumin analogue and docetaxel on growth inhibition of human prostate cancer cells被引量：1
《Journal of Chinese Pharmaceutical Sciences》2017年第11期827-833,共7页周代营 丁立 王希 马娟 黄沃林 Susan Goodin 郑希 
The National Cancer Institute of China(Grant No.P30-CA072720);the National Natural Science Foundation of China(Gr ant No.81272452);the PhD Start-up Fund of Natural Science Foundation of Guangdong Province,China(Grant No.2014A030310329)
Cancer of the prostate gland is a leading cause of death. In the present study, we studied the effects and mechanisms of curcumin analogue E10, docetaxel or their combination on prostate cancer （PC）-3 cells. Treatme...
关键词：Combination treatment Prostate cancer Curcumin analogue DOCETAXEL Synergistic effect 
Vanadium compounds induce stronger growth suppression in PTEN-deficient prostate cancer cells by ROS-mediated mechanism被引量：2
《Journal of Chinese Pharmaceutical Sciences》2017年第6期432-439,共8页洪艺华 刘曈彤 刘彦君 吴竞轩 杨晓改 
National Natural Science Foundation of China(G rant No.21171011 and 21671009)
In the present study, we investigated the antiproliferative effect and the underlying mechanism of three antidiabetic vanadium compounds, metavanadate, VO（acac）2 and VO（ma）2, in human prostate cancer cells （PC-3 ...
关键词：Vanadium compounds Reactive oxygen species PTEN Prostate cancer DIABETES 
全选清除导出
共2页<12>
检索报告 对象比较 聚类工具 使用帮助 返回顶部