RETROVIRAL

作品数：52被引量：68H指数：6
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相关领域：医药卫生生物学更多>>
相关作者：关菁魏丽惠马俐君李希王轩更多>>
相关机构：北京医科大学人民医院南京医科大学上海交通大学医学院附属瑞金医院北京医科大学更多>>
相关期刊：《World Journal of Biological Chemistry》《Asian Pacific Journal of Tropical Medicine》《Cell Regeneration》《Science China(Life Sciences)》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划福建省自然科学基金更多>>
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Endogenous retroviral ERVH48‑1 promotes human urine cell reprogramming
《Cell Regeneration》2024年第1期212-226,共15页Yuling Peng Jieying Zhu Qi Zhang Ran Zhang Zhenhua Wang Zesen Ye Ning Ma Dajiang Qin Duanqing Pei Dongwei Li 
National Natural Science Foundation of China(32270574,92068201);Science and Technology Projects in Guangzhou(2023A03J0045);Guangzhou Key Laboratory of Biological Targeting Diagnosis and Therapy(202201020379);Key Laboratory of Guangdong Higher Education Institutes(2021KSYS009).
Endogenous retroviruses(ERVs),once thought to be mere remnants of ancient viral integrations in the mammalian genome,are now recognized for their critical roles in various physiological processes,including embryonic d...
关键词：Endogenous retroviruses ERVH48-1 Human embryonic stem cells Induced pluripotent stem cells Urine cell integration-free reprogramming system 
Expression levels and stoichiometry of Hnf1β,Emx2,Pax8 and Hnf4αinfluence direct reprogramming of induced renal tubular epithelial cells
《Cell Regeneration》2024年第1期180-191,共12页Xueli Hu Jianjian Sun Meng Wan Bianhong Zhang Linhui Wang Tao P.Zhong 
Ministry of Science and Technology of the People’s Republic of China(2018YFA0800103,2018YFA0801004);National Natural Science Foundation of China(NSFC31530044,NSFC31970780,NSFC82202056).
Generation of induced renal epithelial cells(iRECs)from fibroblasts offers great opportunities for renal disease mod-eling and kidney regeneration.However,the low reprogramming efficiency of the current approach to ge...
关键词：iRECs Bicistronic retroviral cassettes Renal transcriptional factors 
A single-cell atlas of mouse olfactory bulb chromatin accessibility
《Journal of Genetics and Genomics》2021年第2期147-162,共16页Yin Chen Xiangning Ding Shiyou Wang Peiwen Ding Zaoxu Xu Jiankang Li Mingyue Wang Rong Xiang Xiaoling Wang Haoyu Wang Qikai Feng Jiaying Qiu Feiyue Wang Zhen Fluang Xingliang Zhang Gen Tang Shengping Tang 
supported by Shenzhen Sanming Engineering Project(SZSM202011012);Shenzhen Innovation Science and Technology Committee(JCYJ20180228175358223);National Natural Science Foundation of China(31670742)。
Olfaction,the sense of smell,is a fundamental trait crucial to many species.The olfactory bulb(OB)plays pivotal roles in processing and transmitting odor information from the environment to the brain.The cellular hete...
关键词：scATAC-seq Mouse olfactory bulb Chromatin accessibility Transcription factor Endogenous retroviral elements Co-embedding analysis 
piRNA response to retroviral invasion of the koala genome
《Science Foundation in China》2019年第4期31-31,共1页
With the support by the National Natural Science Foundation of China,the research team led by Prof. Weng Zhi Ping (翁志萍) at the School of Life Sciences and Technology,Tongji University,found that piRNAs were involve...
关键词：INVASION founded COLLABORATION 
Improvement in Socio-Economic Productivity of HIV Positive Individuals on Antiretroviral Treatment in a Private Setting in South India
《World Journal of AIDS》2019年第1期23-32,共10页Fehmida Visnegarwala Glory Alexander Ram Babu 
PLHIV have decreased economic productivity both due to direct and indirect causes. Data from developed countries have shown that at the societal level, high costs ART are offset by increased productivity. We hypothesi...
关键词：PERSONS Living with HIV (PLHIV) Anti RETROVIRAL Treatment (ART) SOCIO-ECONOMIC Status (SES) 
Inhibition of retroviral Gag assembly by non-silencing miRNAs promotes autophagic viral degradation被引量：1
《Protein & Cell》2018年第7期640-651,共12页Na Qu Zhao Ma Mengrao Zhang Muaz N. Rushdi Christopher J. Krueger Antony K. Chen 
We recently reported an unconventional mechanism by which miRNAs inhibit HIV-1 viral production. This occurs when miRNAs bind nonspecifically to the viral structural protein Gag, interfering with viral RNA-medi- ated ...
关键词：microRNA Gag protein AUTOPHAGY 
Retroviral integrase protein and intasome nucleoprotein complex structures被引量：2
《World Journal of Biological Chemistry》2017年第1期32-44,共13页Julia Grawenhoff Alan N Engelman 
Supported by United States National Institutes of Health grant,No.R01AI070042
Retroviral replication proceeds through the integration of a DNA copy of the viral RNA genome into the host cellular genome, a process that is mediated by the viral integrase(IN) protein. IN catalyzes two distinct che...
关键词：DNA integration 3-dimensional structure INTEGRASE Intasome Mouse mammary tumor virus RETROVIRUS Rous sarcoma virus Prototype foamy virus Human immunodeficiency virus/acquired immune deficiency syndrome 
SYBR Green I-based product-enhanced reverse transcriptase assay for quantification of retroviral PFV and detection of the divalent cation preference of PFV RT
《Virologica Sinica》2014年第5期314-317,共4页Xiaofang Yi Yan Sun Qingmei Liu Zhi Li Wanhong Liu Xiaohua He Linjuan Zhang Yuxin Wang 
supported by grants from the National Natural Science Foundation of China(No.31000086,No.31170154,No.1371790);the Fundamental Research Funds for the Central Universities(GK201305001,GK201404003);the Innovative Experiment Projects of Educational Ministry of China for Undergraduate(201310718053,cx14069)
Dear Editor,Prototype foamy virus(PFV)belongs to the genus Spumavirus in the Spumaretrovirinae subfamily of Retroviridae.Although PFV and HIV have much in common,research into PFV has lagged far behind that into HIV,a...
关键词：PREFERENCE transcriptase SUBFAMILY PATHOGENIC quantification DIVALENT belongs behind infected template 
Reversible immortalization of human hepatocytes mediated by retroviral transfer and site-specific recombination被引量：6
《World Journal of Gastroenterology》2014年第36期13119-13126,共8页Fan-Ying Meng Li Liu Feng-Hui Yang Chun-You Li Jun Liu Ping Zhou 
Supported by Major Scientific and Technological Project of Shandong Province,No.201221019;Cisco Clinical Oncology Research Fund and Bayer Schering Cancer Research Fund,No.Y-B2012-011
AIM: To establish a method for the reversible immortalization of human hepatocytes, which may offer a good and safe source of hepatocytes for practical applications.
关键词：HEPATOCYTE Primary human hepatocytes Reversible immortalization Hepatocyte isolation SV40T 
Construction and expression of retroviral vector pLEGFP-N1-TERT in preparation of seed cells for skin tissue engineering
《Asian Pacific Journal of Tropical Medicine》2013年第12期960-963,共4页Ting Tan Zhi-Qi Hu 
supported by National Natural Science Foundation of China(No.31170949);Natural Science Foundation of Fujian Province(No.2012J05059)
Objective:To construct the retroviral vector pLEGFP-N1-telomerase reverse transcriptase(TERT)and to investigate the expression of TERT in neonatal mouse bypodermal cells.Methods:The polymerase chain reaction(PCR)-ampl...
关键词：TELOMERASE REVERSE transcriptase RETROVIRAL VECTOR Hypodermal CELLS 
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