SIGNALING_PATHWAY

作品数：1025被引量：4366H指数：26
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相关作者：明艳林陈良华刘韶松游利陈瑾瑜更多>>
相关机构：福建医科大学福建省亚热带植物研究所复旦大学附属肿瘤医院第二军医大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金广东省自然科学基金更多>>
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Exploring the interaction between the gut microbiota and cyclic adenosine monophosphate-protein kinase A signaling pathway:a potential therapeutic approach for neurodegenerative diseases
《Neural Regeneration Research》2025年第11期3095-3112,共18页Fengcheng Deng Dan Yang Lingxi Qing Yifei Chen Jilian Zou Meiling Jia Qian Wang Runda Jiang Lihua Huang 
supported by the National Natural Science Foundation of China,No.82003965;the Science and Technology Research Project of Sichuan Provincial Administration of Traditional Chinese Medicine,No.2024MS167(to LH);the Xinglin Scholar Program of Chengdu University of Traditional Chinese Medicine,No.QJRC2022033(to LH);the Improvement Plan for the'Xinglin Scholar'Scientific Research Talent Program at Chengdu University of Traditional Chinese Medicine,No.XKTD2023002(to LH);the 2023 National Project of the College Students'Innovation and Entrepreneurship Training Program at Chengdu University of Traditional Chinese Medicine,No.202310633028(to FD)。
The interaction between the gut microbiota and cyclic adenosine monophosphate(cAMP)-protein kinase A(PKA)signaling pathway in the host's central nervous system plays a crucial role in neurological diseases and enhance...
关键词：cyclic adenosine monophosphate emotional disorders gut microbiota neurodegenerative diseases neurological diseases protein kinase A reciprocal regulation signaling pathway STRATEGY THERAPIES 
Corrigendum:Neuroprotection mediated by the Wnt/Frizzled signaling pathway in early brain injury induced by subarachnoid hemorrhage
《Neural Regeneration Research》2025年第11期3123-3123,共1页
In the article titled“Neuroprotection mediated by the Wnt/Frizzled signaling pathway in early brain injury induced by subarachnoid hemorrhage,”published on pages 1013-1024,Issue 6,Volume 14 of Neural Regeneration Re...
关键词：HEMORRHAGE COR 
Maternal high-fat diet impairs offspring glucose metabolism and programs hepatic DNA methylation linked to NK cell-mediated cytotoxicity signaling pathway at weaning
《Food Science and Human Wellness》2025年第4期1576-1587,共12页Sheng Zheng Ling Zhang Shixuan Zhang Guanyu Hu Yikai Li Jia Zheng 
sponsored by National Natural Science Foundation of China(81800703);Postdoctoral Fellowship Program of China Postdoctoral Science Foundation(GZC20231088);Beijing Nova Program(Z201100006820117 and 20220484181);Beijing Municipal Natural Science Foundation(7184252);the Fundamental Research Funds for the Central Universities;the Fundamental Research Funds for the Central Universities(BMU2021MX013);Peking University Clinical Scientist Training Program(BMU2023PYJH022);Peking University Medicine Seed Fund for Interdisciplinary Research;China Endocrine and Metabolism Young Scientific Talent Research Project(2022-N-02-01);China Diabetes Young Scientific Talent Research Project;Bethune-Merck Diabetes Research Fund of Bethune Charitable Foundation。
Maternal consumption of a high-fat diet has been linked to increased risks of obesity and impaired glucose metabolism in offspring.However,the precise epigenetic mechanisms governing these intergenerational effects,pa...
关键词：Maternal high-fat diet consumption Glucose metabolism DNA methylation Natural killer cell-mediated cytotoxicity WEANING 
Elucidating the anti-obesity phytochemicals in Chenpi and their molecular mechanisms
《Food Science and Human Wellness》2025年第4期1224-1238,共15页Jinhai Luo Weiqi Yan Zhi Chen Baojun Xu 
supported by the Guangdong Provincial Key Laboratory IRADS(2022B1212010006,R0400001-22)。
Obesity has become a significant global public health issue.Previous studies have found that the Chenpi has the anti-obesity activity.However,the anti-obesity phytochemicals and their mechanisms are still unclear.This...
关键词：Chenpi PHYTOCHEMICALS OBESITY Network pharmacology Molecular mechanism Signaling pathway 
Unsaponifiable matter from walnut oil ameliorate memory deficits and mitochondrial dysfunction in aging mice via activating Nrf2 signaling pathway
《Food Science and Human Wellness》2025年第3期1127-1138,共12页Dan Hong Xiao Xiao Aijin Ma Zhou Chen Siting Li Junxia Xia Yiling Tian Yingmin Jia 
supported by the National Key Research and Development Program(2022YFD1600402);Hebei Provincial Major Science and Technology Achievement Transformation Project(21287101Z);Hebei Provincial Innovation and Entrepreneurship Team Project(215A7102D)。
Aging is an inevitable biological phenomenon that involves a multitude of physiological alterations.Dietary interventions are being considered as potential strategies for delaying age-related dysfunction.Unsaponifiabl...
关键词：Unsaponifiable matter Memory impairment mitochondrial dysfunctions Nrf2 signaling pathway Antioxidant stress 
miRNA-21-5p targeting PTEN to regulate PI3K/Akt/mTOR pathway in retinal pigment epithelial cell photodamage
《International Journal of Ophthalmology(English edition)》2025年第4期575-581,共7页Juan Li Ruo-Di Shi Qing Li Chen Xu Yang Yu 
AIM:To highlight the importance of microRNA(miRNA)-21-5p in directing the phosphatase and tensin homolog(PTEN)gene to control the phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin(PI3K/Akt/mTOR)...
关键词：retinal pigment epithelial cell PHOTODAMAGE apoptosis PI3K/Akt/mTOR signaling pathway miRNA-21-5p 
Size-dependent toxicity of microplastics induced gut cell apoptosis in brine shrimp Artemia parthenogenetica through p53 signaling pathway
《Journal of Oceanology and Limnology》2025年第2期614-623,共10页Junfang WANG Zhichao YAN Yulong LU Wei XIE Liying SUI 
Supported by the Program of Sustainable Development and Protection of Artemia Resources in Yuncheng Salt Lake of China(No.YHYJ-2023005)。
Microplastics(MPs)are one of the most concerning pollutants that affects the health and growth of aquatic organisms.We characterized the MPs dispersion in the milli-Q water and seawater,and evaluated the effects of MP...
关键词：polystyrene microplastic brine shrimp GUT oxidative stress apoptosis-related gene mitochondrial membrane potential 
Long term ingestion of dietary ALEs induces metabolic disorders in mice by inducing gut dysbiosis and inhibiting AMPK/SIRT1 pathway
《Food Science and Human Wellness》2025年第2期439-449,共11页Yaya Wang Tianchang Zhang Linqing Nie Yan Zhang Junping Wang Shuo Wang 
supported by grants from the National Natural Science Foundation of China(32030083)。
Advanced lipoxidation end products(ALEs)are formed by modifying proteins with lipid oxidation products.ALEs formed in the body have been linked to diabetes and hepatic disease.However,it is not known whether ALEs form...
关键词：Dietary advanced lipoxidation end products Metabolic disorders AMPK/SITR1 signaling pathway Gut dysbiosis Intestinal barrier 
Netrin-1 signaling pathway mechanisms in neurodegenerative diseases
《Neural Regeneration Research》2025年第4期960-972,共13页Kedong Zhu Hualong Wang Keqiang Ye Guiqin Chen Zhaohui Zhang 
supported by the National Natural Science Foundation of China(Youth Science Fund Project),No.81901292(to GC);the National Key Research and Development Program of China,No.2021YFC2502100(to GC);the National Natural Science Foundation of China,No.82071183(to ZZ).
Netrin-1 and its receptors play crucial roles in inducing axonal growth and neuronal migration during neuronal development.Their profound impacts then extend into adulthood to encompass the maintenance of neuronal sur...
关键词：Alzheimer’s disease axon guidance colorectal cancer Netrin-1 receptors Netrin-1 signaling pathways NETRIN-1 neurodegenerative diseases neuron survival Parkinson’s disease UNC5C 
Inhibition of ITGA2 suppresses cervical tumorigenesis and metastasis by targeting the AKT/mTOR signaling pathway
《Genes & Diseases》2025年第2期86-89,共4页Haixia Luo Jingjing Chang Yiting Ren Xiu Zhang Yuanxing Li Miao Huo Hongyuan Wang Xin Yang Jianbing Liu Qingmei Zhang Yueyang Zhao Wei Wang 
supported by grants from the Applied Basic Research Program of Shanxi,China (No.20210302123277);the Key Research and Development Program of Shanxi,China (No.201903D321152);the National Natural Science Foundation of China (No.82373107).
Cervical cancer(CCa)is a substantial global health concern,and its lymph node metastasis(LNM)significantly diminishes patients'survival rates.1 Hence,a thorough investigation into the molecular mechanisms driving this...
关键词：METASTASIS ITG cancer 
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