This work is supported by the Strategic Priority Research Program of Chinese Academy of Sciences(XDA16010601);the CAS Key Research Program of Frontier Sciences(QYZDB-SSW-SMC057);the Major Research and Development Project of Guangzhou Regenerative Medicine and Health Guangdong Laboratory(2018GZR110104006);the Chinese Ministry of Science and Technology(2015CB964401,2016YFA0100601,2017YFA0103401,2015CB964902,and 2015CB964901);the Health and Medical Care Collaborative Innovation Program of Guangzhou Scientific and Technology(201803040017);the Major Scientific and Technological Project of Guangdong Province(2014B020225005);the Science and Technology Planning Project of Guangdong Province(2017B030314056);the Program for Guangdong Introducing Innovative and Entrepreneurial Teams(2017ZT07S347);the National Natural Science Foundation of China(31471117,81470281,31600948,31425012).
Achievement of immunocompetent and therapeutic T lymphopoiesis from pluripotent stem cells(PSCs)is a central aim in T cell regenerative medicine.To date,preferentially reconstituting T lymphopoiesis in vivo from PSCs ...
Acknowledgments We are grateful to ABRC and Drs Ben Scheres (UtrechtUniversity, Netherlands), Jim Haseloff (University of Cambridge, UK), Nam-Hai Chua (Rockefeller University, USA) for providing the seeds and constructs used in this study. This work was supported by the Ministry of Science and Technology of China (2007CB948200) and by the National Natural Science Foundation of China (30900108 and 30821007).
The remarkable regeneration capability of plant tissues or organs under culture conditions has underlain an extensive practice for decades. The initial step in plant in vitro regeneration often involves the induction ...
p53, NFKB, STAT3, and several other transcription factors are reversibly methylated on lysine residues by enzymes that also modify histones. The methylations of NFKB and STAT3 take place when they are bound to promote...
This work was supported by the National Basic Research Program of China (Grant Nos. 2009CB918404 and 2006CB910700), International S&T Cooperation Program of China (Grant No. 2007DFA31040) and the National Natural Science Foundation of China (Grant Nos. 30700154 and 31070746).
Dear Editor, Eukaryotic transcriptional regulation networks are extremely complex. Usually, multiple transcription factors (TFs) bind to the promoter region of a gene and cooperate to control gene expression precisely...
CD4 T helper (Th) cells play critical roles in adaptive immune responses. They recruit and activate other immune cells including B cells, CD8 T cells, macrophages, mast cells, neutrophils, eosinophils and basophils....
MYB proteins are transcription factors present in all eukaryotes, sharing a common DNA-binding domain that consists of one to three imperfect helix-helix-turn-helix repeats of about 50 amino acids, called R1, R2, and ...
Acknowledgment This research was supported by grants from the Ministry of Science and Technology of China (2006CB943901, 2007CB948003); the National Natural Science Foundation of China (30600306, 30623003); Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences (2007KIP 101,2007KIP401), Chinese Academy of Sciences.
Dear Editor, Human embryonic stem (ES) cells possess the potential to differentiate into all the cell types of the human body and provide potential applications in regenerative medicine . However, the concerns of i...
This work was supported by grants from the National Natural Science Foundation of China (30370694, 30421005, 30623003, 30400245 and 30630036), the Ministry of Science and Technology of China (2002CB513006, 2006CB943902 and 2006AA02Z 169), the Chinese Acad- emy of Sciences (KSCX2-YW-R-67 and KJCX2-YW-H08) and the Shanghai Municipal Commission for Science and Technology (04JC14078, 06DZ22032, 055407035 and 058014578).
The NF-kB transcription factors modulate the expression of tissue factor (TF), E-selectin (CD62E) and vascular cell adhesion molecule-1 (VCAM-1), which are essential for thrombosis and inflammation. We have prev...
Hybridoma cells display an increase in antibody productivity following exposure to hypertonic conditions. However, the underlying mechanism is not well understood. In the present study, we hypothesize that the nuclear...
Heme (iron protoporphyrin IX) is an essential molecule for numerous living organisms. Not only does it serve as a prosthetic group in enzymes, it also acts as a signaling molecule that controls diverse molecular and...