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作品数:325被引量:1838H指数:21
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相关作者:张萍陈伟盛志勇付小兵夏维波更多>>
相关机构:中山大学孙逸仙纪念医院解放军第304医院北京协和医院国际马铃薯研究中心更多>>
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Guiding T lymphopoiesis from pluripotent stem cells by defined transcription factors被引量:8
《Cell Research》2020年第1期21-33,共13页Rongqun Guo Fangxiao Hu Qitong Weng Cui Lv Hongling Wu Lijuan Liu Zongcheng Li Yang Zeng Zhijie Bai Mengyun Zhang Yuting Liu Xiaofei Liu Chengxiang Xia Tongjie Wang Peiqing Zhou Kaitao Wang Yong Dong Yuxuan Luo Xiangzhong Zhang Yuxian Guan Yang Geng Juan Du Yangqiu Li Yu Lan Jiekai Chen Bing Liu Jinyong Wang 
This work is supported by the Strategic Priority Research Program of Chinese Academy of Sciences(XDA16010601);the CAS Key Research Program of Frontier Sciences(QYZDB-SSW-SMC057);the Major Research and Development Project of Guangzhou Regenerative Medicine and Health Guangdong Laboratory(2018GZR110104006);the Chinese Ministry of Science and Technology(2015CB964401,2016YFA0100601,2017YFA0103401,2015CB964902,and 2015CB964901);the Health and Medical Care Collaborative Innovation Program of Guangzhou Scientific and Technology(201803040017);the Major Scientific and Technological Project of Guangdong Province(2014B020225005);the Science and Technology Planning Project of Guangdong Province(2017B030314056);the Program for Guangdong Introducing Innovative and Entrepreneurial Teams(2017ZT07S347);the National Natural Science Foundation of China(31471117,81470281,31600948,31425012).
Achievement of immunocompetent and therapeutic T lymphopoiesis from pluripotent stem cells(PSCs)is a central aim in T cell regenerative medicine.To date,preferentially reconstituting T lymphopoiesis in vivo from PSCs ...
关键词:ORGANS RESTRICTED GRAFT 
LATERAL ORGAN BOUNDARIES DOMAIN transcription factors direct callus formation in Arabidopsis regeneration被引量:54
《Cell Research》2012年第7期1169-1180,共12页Mingzhu Fan Chongyi Xu Ke Xu Yuxin Hu 
Acknowledgments We are grateful to ABRC and Drs Ben Scheres (UtrechtUniversity, Netherlands), Jim Haseloff (University of Cambridge, UK), Nam-Hai Chua (Rockefeller University, USA) for providing the seeds and constructs used in this study. This work was supported by the Ministry of Science and Technology of China (2007CB948200) and by the National Natural Science Foundation of China (30900108 and 30821007).
The remarkable regeneration capability of plant tissues or organs under culture conditions has underlain an extensive practice for decades. The initial step in plant in vitro regeneration often involves the induction ...
关键词:LBD callus formation AUXIN REGENERATION ARABIDOPSIS 
Lysine methylation of promoter-bound transcription factors and relevance to cancer被引量:3
《Cell Research》2011年第3期375-380,共6页George R Stark Yuxin Wang Tao Lu 
p53, NFKB, STAT3, and several other transcription factors are reversibly methylated on lysine residues by enzymes that also modify histones. The methylations of NFKB and STAT3 take place when they are bound to promote...
关键词:posttranslational modification HISTONES transcription factors 
Identifying cooperative transcription factors by combining ChiP-chip data and knockout data
《Cell Research》2010年第11期1276-1278,共3页Yi Yang Zili Zhang Yixue Li Xin-Guang Zhu Qi Liu 
This work was supported by the National Basic Research Program of China (Grant Nos. 2009CB918404 and 2006CB910700), International S&T Cooperation Program of China (Grant No. 2007DFA31040) and the National Natural Science Foundation of China (Grant Nos. 30700154 and 31070746).
Dear Editor, Eukaryotic transcriptional regulation networks are extremely complex. Usually, multiple transcription factors (TFs) bind to the promoter region of a gene and cooperate to control gene expression precisely...
关键词:转录因子 基因敲除 合作 数据资料 芯片 识别 真核基因转录 基因组序列 
Heterogeneity and plasticity of T helper cells被引量:41
《Cell Research》2010年第1期4-12,共9页Jinfang Zhu William E Paul 
CD4 T helper (Th) cells play critical roles in adaptive immune responses. They recruit and activate other immune cells including B cells, CD8 T cells, macrophages, mast cells, neutrophils, eosinophils and basophils....
关键词:CD4 TREGS T cell differentiation transcription factors CYTOKINES 
A new role for plant R2R3-MYB transcription factors in cell cycle regulation被引量:7
《Cell Research》2009年第11期1231-1232,共2页Eleonora Cominelli Chiara Tonelli 
MYB proteins are transcription factors present in all eukaryotes, sharing a common DNA-binding domain that consists of one to three imperfect helix-helix-turn-helix repeats of about 50 amino acids, called R1, R2, and ...
关键词:MYB转录因子 细胞周期调控 植物 DNA结合域 真核生物 基因家族 基因蛋白 蛋白质 
Enhanced efficiency of generating induced pluripotent stem (iPS) cells from human somatic cells by a combination of six transcription factors被引量:62
《Cell Research》2008年第5期600-603,共4页Jing Liao Zhao Wu Ying Wang Lu Cheng Chun Cui Yuan Gao Taotao Chen Lingjun Rao Siye Chen Nannan Jia Huiming Dai Shunmei Xin Jiuhong Kang Gang Pei Lei Xiao 
Acknowledgment This research was supported by grants from the Ministry of Science and Technology of China (2006CB943901, 2007CB948003); the National Natural Science Foundation of China (30600306, 30623003); Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences (2007KIP 101,2007KIP401), Chinese Academy of Sciences.
Dear Editor, Human embryonic stem (ES) cells possess the potential to differentiate into all the cell types of the human body and provide potential applications in regenerative medicine . However, the concerns of i...
关键词:胚胎干细胞 体细胞 再生医学 转录因子 
Andrographolide inhibits NF-KB activation and attenuates neointimal hyperplasia in arterial restenosis被引量:11
《Cell Research》2007年第11期933-941,共9页YuJiu Wang Jin Tao Wang QuanXin Fan Jian Guo Geng 
This work was supported by grants from the National Natural Science Foundation of China (30370694, 30421005, 30623003, 30400245 and 30630036), the Ministry of Science and Technology of China (2002CB513006, 2006CB943902 and 2006AA02Z 169), the Chinese Acad- emy of Sciences (KSCX2-YW-R-67 and KJCX2-YW-H08) and the Shanghai Municipal Commission for Science and Technology (04JC14078, 06DZ22032, 055407035 and 058014578).
The NF-kB transcription factors modulate the expression of tissue factor (TF), E-selectin (CD62E) and vascular cell adhesion molecule-1 (VCAM-1), which are essential for thrombosis and inflammation. We have prev...
关键词:NF-kB transcription factors ANDROGRAPHOLIDE neointimal hyperplasia arterial restenosis TF E-SELECTIN VCAM-I 
Downregulation of NFAT5 by RNA interference reduces monoclonal antibody productivity of hybridoma cells被引量:4
《Cell Research》2007年第3期264-270,共7页Jihang Ju Ke Zou Hong Xie 
Hybridoma cells display an increase in antibody productivity following exposure to hypertonic conditions. However, the underlying mechanism is not well understood. In the present study, we hypothesize that the nuclear...
关键词:antibody formation HYBRIDOMAS NFAT transcription factors RNA interference 
Heme:a versatile signaling molecule controlling the activities of diverse regulators ranging from transcription factors to MAP kinases被引量:6
《Cell Research》2006年第8期681-692,共12页SarahMMense 
Heme (iron protoporphyrin IX) is an essential molecule for numerous living organisms. Not only does it serve as a prosthetic group in enzymes, it also acts as a signaling molecule that controls diverse molecular and...
关键词:heme signaling oxygen sensing Hapl Bachl HRI IRR 
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