TRAUMATIC_BRAIN_INJURY

作品数:529被引量:1727H指数:18
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相关作者:侯立军胡锦周良辅王杨孙一睿更多>>
相关机构:复旦大学第二军医大学第三军医大学西南医院中南大学更多>>
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相关基金:国家自然科学基金天津市自然科学基金中国博士后科学基金国家重点基础研究发展计划更多>>
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Fat mass and obesity-mediated N^(6)-methyladenosine modification modulates neuroinflammatory responses after traumatic brain injury
《Neural Regeneration Research》2026年第2期730-741,共12页Xiangrong Chen Jinqing Lai Zhe Wu Jianlong Chen Baoya Yang Chunnuan Chen Chenyu Ding 
supported by grants from the Major Projects of Health Science Research Foundation for Middle-Aged and Young Scientist of Fujian Province,China,No.2022ZQNZD01010010;the National Natural Science Foundation of China,No.82371390;Fujian Province Scientific Foundation,No.2023J01725(all to XC).
The neuroinflammatory response mediated by microglial activation plays an important role in the secondary nerve injury of traumatic brain injury.The post-transcriptional modification of N^(6)-methyladenosine is ubiqui...
关键词:ADAM17 epigenetic modification fat mass and obesity N6-methyladenosine MICROGLIA mRNA nerve injury NEUROINFLAMMATION traumatic brain injury tumor necrosis factorα 
Microglial polarization pathways and therapeutic drugs targeting activated microglia in traumatic brain injury
《Neural Regeneration Research》2026年第1期39-56,共18页Liping Shi Shuyi Liu Jialing Chen Hong Wang Zhengbo Wang 
supported by the Natural Science Foundation of Yunnan Province,No.202401AS070086(to ZW);the National Key Research and Development Program of China,No.2018YFA0801403(to ZW);Yunnan Science and Technology Talent and Platform Plan,No.202105AC160041(to ZW);the Natural Science Foundation of China,No.31960120(to ZW)。
Traumatic brain injury can be categorized into primary and secondary injuries.Secondary injuries are the main cause of disability following traumatic brain injury,which involves a complex multicellular cascade.Microgl...
关键词:animal model anti-inflammatory drug cell replacement strategy central nervous system mesenchymal stem cell MICROGLIA NEUROINFLAMMATION non-human primate signaling pathway traumatic brain injury 
Nanocarrier-mediated siRNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's disease
《Neural Regeneration Research》2025年第9期2538-2555,共18页Jie Jin Huajing Zhang Qianying Lu Linqiang Tian Sanqiao Yao Feng Lai Yangfan Liang Chuanchuan Liu Yujia Lu Sijia Tian Yanmei Zhao Wenjie Ren 
supported by Open Project of the Key Laboratory of Trauma and Orthopedics Research Medicine in Henan Province,No.HZKFKT20220504(to YZ);the National Natural Science Foundation of China,No.32000877(to YZ);and Open Scientific Research Program of Military Logistics,No.BLB20J009(to YZ)。
Traumatic brain injury and Alzheimer's disease share pathological similarities,including neuronal loss,amyloid-βdeposition,tau hyperphosphorylation,blood-brain barrier dysfunction,neuroinflammation,and cognitive defi...
关键词:blood-brain barrier cognitive dysfunction EXOSOMES gene silencing immunotherapy inorganic nanomaterials liposome nanoparticles NEUROINFLAMMATION polymer nanoparticles stem cells 
Astrocytes, reactive astrogliosis, and glial scar formation in traumatic brain injury被引量:2
《Neural Regeneration Research》2025年第4期973-989,共17页María Belén Cieri Alberto Javier Ramos 
supported by grants PICT 2019-0851;2017-2203,UBACYT and PIP CONICET(to AJR).
Traumatic brain injury is a global health crisis,causing significant death and disability worldwide.Neuroinflammation that follows traumatic brain injury has serious consequences for neuronal survival and cognitive im...
关键词:ASTROCYTE glial scar innate immunity NEUROINFLAMMATION stab injury Toll-like receptors 
Repetitive traumatic brain injury–induced complement C1–related inflammation impairs long-term hippocampal neurogenesis被引量:1
《Neural Regeneration Research》2025年第3期821-835,共15页Jing Wang Bing Zhang Lanfang Li Xiaomei Tang Jinyu Zeng Yige Song Chao Xu Kai Zhao Guoqiang Liu Youming Lu Xinyan Li Kai Shu 
supported by the Fundamental Research Program of Shanxi Province of China,No.20210302124277;the Science Foundation of Shanxi Bethune Hospital,No.2021YJ13(both to JW)。
Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus,leading to long-term cognitive impairment.However,the mechanism underlying this neurogenesis impairment remains unknown.In ...
关键词:complement C1 dendrite dentate gyrus hippocampus neural stem cell NEUROGENESIS NEUROINFLAMMATION neurological function neuron traumatic brain injury 
Connecting cellular mechanisms and extracellular vesicle cargo in traumatic brain injury被引量:1
《Neural Regeneration Research》2024年第10期2119-2131,共13页Nikita Ollen-Bittle Austyn D.Roseborough Wenxuan Wang Jeng-liang D.Wu Shawn N.Whitehead 
supported by Canadian Institutes for Health Research (CIHR)(to ADR and WW);Ontario Graduate Scholarship (to NOB);Alzheimer's Society of Canada;Heart and Stroke Foundation of Canada,CIHR;the Canadian Consortium for Neurodegeneration and Aging (CCNA)(to SNW)。
Traumatic brain injury is followed by a cascade of dynamic and complex events occurring at the cellular level. These events include: diffuse axonal injury, neuronal cell death, blood-brain barrier break down, glial ac...
关键词:axonal injury biomarkers blood-brain barrier chronic traumatic encephalopathy extracellular vesicles glial activation NEUROINFLAMMATION traumatic brain injury 
Autophagy in neuroinflammation after traumatic brain injury被引量:3
《Neural Regeneration Research》2024年第5期951-952,共2页Chinmoy Sarkar Marta M.Lipinski 
supported by NIH funding(R01NS091218 and R01NS115876)to MML.
Traumatic brain injury(TBI)is an acquired injury of the brain caused by the impact of external forces on the brain(Maas et al.,2008).It is a major cause of death and disability among people of all ages(Maas et al.,200...
关键词:DAMAGE DEATH AFTER 
Versatile strategies for adult neurogenesis:avenues to repair the injured brain被引量:2
《Neural Regeneration Research》2024年第4期774-780,共7页Junyi Zhao Siyu Liu Xianyuan Xiang Xinzhou Zhu 
supported by the SIAT Innovation Program for Excellent Young Researchers,No.E1G0241001(to XZ)。
Brain injuries due to trauma or stroke are major causes of adult death and disability.Unfortunately,few interventions are effective for post-injury repair of brain tissue.After a long debate on whether endogenous neur...
关键词:adult neurogenesis glia-to-neuron conversion ischemic stroke neurogenic niche NEUROINFLAMMATION stem cell transplantation traumatic brain injury 
Gut microbial regulation of innate and adaptive immunity after traumatic brain injury被引量:6
《Neural Regeneration Research》2024年第2期272-276,共5页Marta Celorrio Kirill Shumilov Stuart H.Friess 
Acute care management of traumatic brain injury is focused on the prevention and reduction of secondary insults such as hypotension,hypoxia,intracranial hypertension,and detrimental inflammation.However,the imperative...
关键词:gut microbiome gut microbiota gut-brain axis macrophage MICROGLIA MONOCYTE NEUROINFLAMMATION short-chain fatty acids T cell traumatic brain injury 
Mesenchymal stem cell-derived extracellular vesicles as a cell-free therapy for traumatic brain injury via neuroprotection and neurorestoration被引量:2
《Neural Regeneration Research》2024年第1期49-54,共6页Ye Xiong Asim Mahmood Michael Chopp 
supported by Notional Institutes of Health Grant,No.1R01NS100710-01A1(to YX)。
Traumatic brain injury is a serious and complex neurological condition that affects millions of people worldwide.Despite significant advancements in the field of medicine,effective treatments for traumatic brain injur...
关键词:biomarkers extracellular vesicles functional outcome mesenchymal stem/stromal cells NEUROINFLAMMATION NEUROPLASTICITY NEUROPROTECTION traumatic brain injury 
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