supported by the Shanghai Municipal Severe Mental Illness Key Laboratory Programme(14-K03);the Shanghai Municipal Health System Important Disease Cooperative Research Programme(2014ZYJB0002);the Shanghai Municipal Commission of Health and Family Planning Key Programme(20134006);the Shanghai Municipal Hospital Appropriate Technology Programme(SHDC12014214);the Programme of the National Natural Science Foundation of China(81371479);a research grant from the Shanghai Mental Health Center(2012-YJ-06);a grant from the Shanghai Municipal Mental Illness Clinical Medicine Center(2014)