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Utilizing Single-cell and Spatial RNA-seq databasE for Alzheimer’s Disease(ssREAD)in hypothesis-driven queries: 《Neural Regeneration Research》2026年第2期677-678,共2页Diana Acosta Cankun Wang Qin Ma Hongjun Fu; Alzheimer’s disease(AD)is the most common form of dementia.In addition to the lack of effective treatments,there are limitations in diagnostic capabilities.The complexity of AD itself,together with a variety of other...; 关键词：sex specific alzheimer s disease ad deciphering molecular mechanisms spatial transcriptomics ssread spatial transcriptomics st Alzheimers disease single cell RNA seq

Amyloid-βis NOT only the most promising target for Alzheimer’s disease: 《Neural Regeneration Research》2026年第2期681-682,共2页Beka Solomon Milana Voronov-Goldman; Amyloid-β(Aβ)and tau,the two hallmark proteins associated with Alzheimer’s disease(AD),exhibit distinct toxic effects but also interact synergistically within the disease pathology.The prevailing theory in AD patho...; 关键词：amyloid precursor protein app initially intracellular peptides amyloid cascade hypothesis amyloid cascade hypothesis highlights AMYLOID tau Alzheimers disease SECRETASE

Exosomes in neurodegenerative diseases:Therapeutic potential and modification methods: 《Neural Regeneration Research》2026年第2期478-490,共13页Hongli Chen Na Li Yuanhao Cai Chunyan Ma Yutong Ye Xinyu Shi Jun Guo Zhibo Han Yi Liu Xunbin Wei; supported by the National Natural Science Foundation of China,No.22103055(to JG);the Natural Science Foundation of Hebei Province,No.F2024110001(to HC);and Open Project of Tianjin Key Laboratory of Optoelectronic Detection Technology and System,Nos.2024LODTS215(to NL),2024LODTS216(to XS).; In recent years,exosomes have garnered extensive attention as therapeutic agents and early diagnostic markers in neurodegenerative disease research.Exosomes are small and can effectively cross the blood-brain barrier,...; 关键词：Alzheimer’s disease cell recognition central nervous system diseases enhanced targeting exosome modification exosome targeting neurodegenerative disease Parkinson’s disease stem cell exosomes stem cell therapy

Chemical exchange saturation transfer MRI for neurodegenerative diseases:An update on clinical and preclinical studies: 《Neural Regeneration Research》2026年第2期553-568,共16页Ahelijiang Saiyisan Shihao Zeng Huabin Zhang Ziyan Wang Jiawen Wang Pei Cai Jianpan Huang; supported by The University of Hong Kong,China(109000487,109001694,204610401,and 204610519);National Natural Science Foundation of China(82402225)(to JH).; Chemical exchange saturation transfer magnetic resonance imaging is an advanced imaging technique that enables the detection of compounds at low concentrations with high sensitivity and spatial resolution and has been...; 关键词：Alzheimer’s disease chemical exchange saturation transfer Huntington’s disease magnetic resonance imaging molecular imaging multiple sclerosis neurodegenerative disease Parkinson’s disease

Insights into the transcriptomic heterogeneity of brain endothelial cells in normal aging and Alzheimer’s disease: 《Neural Regeneration Research》2026年第2期569-576,共8页Qian Yue Shang Li Chon Lok Lei Huaibin Wan Zaijun Zhang Maggie Pui Man Hoi; supported by the National Natural Science Foundation of China,Nos.82404892(to QY),82061160374(to ZZ);the Science and Technology Development Fund,Macao Special Administrative Region,China,Nos.0023/2020/AFJ,0035/2020/AGJ;the University of Macao Research Grant,Nos.MYRG2022-00248-ICMS,MYRG-CRG2022-00010-ICMS(to MPMH);the Natural Science Foundation of Guangdong Province,No.2024A1515012818(to ZZ);the Fundamental Research Funds for the Central Universities,No.21623114(to ZZ).; Drug development for Alzheimer’s disease is extremely challenging,as demonstrated by the repeated failures of amyloid-β-targeted therapeutics and the controversies surrounding the amyloid-βcascade hypothesis.More r...; 关键词：Alzheimer’s disease brain microvessel endothelial cells transcriptomic heterogeneity endothelial activation blood-brain barrier impairment neurovascular cell-cell communication

Recent advances in immunotherapy targeting amyloid-beta and tauopathies in Alzheimer’s disease: 《Neural Regeneration Research》2026年第2期577-587,共11页Sha Sha Lina Ren Xiaona Xing Wanshu Guo Yan Wang Ying Li Yunpeng Cao Le Qu; supported by the Nature Science Foundation of Liaoning Province,Nos.2022-MS-211,2021-MS-064,and 2024-MS-048(all to YC).; Alzheimer’s disease,a devastating neurodegenerative disorder,is characterized by progressive cognitive decline,primarily due to amyloid-beta protein deposition and tau protein phosphorylation.Effectively reducing the...; 关键词：Alzheimer’s disease amyloid deposits AMYLOID-BETA antibody cognitive dysfunction dementia IMMUNOTHERAPY OLIGOMER preventive immunization tau hyperphosphorylation

ABCA5 lipid transporter is associated with a reduced risk of Parkinson’s disease: 《Neural Regeneration Research》2026年第2期669-670,共2页Jasmin Galper Nicolas Dzamko Woojin Scott Kim; A key pathological feature of Parkinson’s disease(PD)is that lysosomes are overwhelmed with cellular materials that need to be degraded and cleared.While the build-up of protein is characteristic of neurodegenerative...; 关键词：neurodegenerative diseases lipid transporter abca LYSOSOME protein build up Alzheimers disease cellular materials Parkinsons disease

Biomarkers for synaptic dysfunction in Alzheimer’s disease: 《Neural Regeneration Research》2026年第2期683-684,共2页Ruiqing Ni; supported by Swiss Center for Applied Human Toxicology(SCAHT AP22-01)(to RN).; Alzheimer’s disease(AD)is the most common cause of dementia,characterized by progressive cognitive decline,and affects over 55 million people worldwide.AD is pathological featured by the aberrant accumulation of amyl...; 关键词：vivo autopsy studies synaptic dysfunction loss alzheimer s disease ad amyloid plaques cognitive declineand Alzheimers disease dysfunction neurotransmitter systemsevidence synaptic dysfunction

Pathological axonal enlargement in connection with amyloidosis,lysosome destabilization,and bleeding is a major defect in Alzheimer’s disease: 《Neural Regeneration Research》2026年第2期790-799,共10页Hualin Fu Jilong Li Chunlei Zhang Guo Gao Qiqi Ge Xinping Guan Daxiang Cui; supported by the National Natural Science Foundation of China,No.81472235(to HF);the Shanghai Jiao Tong University Medical and Engineering Project,Nos.YG2021QN53(to HF),YG2017MS71(to HF);the International Cooperation Project of the National Natural Science Foundation of China,No.82020108017(to DC);the Innovation Group Project of the National Natural Science Foundation of China,No.81921002(to DC).; Alzheimer’s disease is a multi-amyloidosis disease characterized by amyloid-βdeposits in brain blood vessels,microaneurysms,and senile plaques.How amyloid-βdeposition affects axon pathology has not been examined ex...; 关键词：Alzheimer’s disease amyloid-β AMYLOIDOSIS axonal enlargement hemoglobin hemorrhage lysosome destabilization neuropil thread tau Wallerian degeneration

Systematic review of amyloid-beta clearance proteins from the brain to the periphery:implications for Alzheimer's disease diagnosis and therapeutic targets: 《Neural Regeneration Research》2025年第12期3574-3590,共17页Letian Huang Mingyue Liu Ze Li Bing Li Jiahe Wang Ke Zhang; supported by the National Natural Science Foundation of China,No.81571046(to KZ);Key Project of Educational Department of Liaoning Province,No.LJKZ0755(to KZ);Project of Department of Science&Technology of Liaoning Province,No.2023JH2/20200116(to KZ);Shenyang Young and Middleaged Innovative Talents Support Program,No.RC210240(to KZ);the 345 Talent Project of Shengjing Hospital of China Medical University(to LH)。; Amyloid-beta clearance plays a key role in the pathogenesis of Alzheimer's disease.H oweve r,the variation in functional proteins involved in amyloid-beta clearance and their correlation with amyloid-beta levels remai...; 关键词：Alzheimer’s disease amyloid-β blood‒brain barrier cerebrospinal fluid diagnostic biomarker meta-analysis mild cognitive impairment peripheral blood systematic review therapeutic targets

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