CA2+

作品数：937被引量：3375H指数：20
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Compound heterozygous mutation of AFG3L2 causes autosomal recessive spinocerebellar ataxia through mitochondrial impairment and MICU1 mediated Ca2+overload
《Science China(Life Sciences)》2025年第2期484-501,共18页Hongyu Li Qingwen Ma Yan Xue Linlin Cai Liwen Bao Lei Hong Yitao Zeng Shu-Zhen Huang Richard H.Finnell Fanyi Zeng 
supported by the National Key Research and Development Program of China(2019YFA0801402);the National Natural Science Foundation of China(82271890);the Shanghai Key Clinical Specialty Project(shslczdzk05705);the Shanghai Top Priority Key Discipline Project(2017ZZ02019);Innovative Research Team of High-Level Local Universities in Shanghai(SHSMU-ZDCX20212200);the Macao Science and Technology Development Fund(FDCT)(0092/2022/A2,003/2022/ALC)。
Autosomal recessive spinocerebellar ataxias(SCARs)are one of the most common neurodegenerative diseases characterized by progressive ataxia.Although SCARs are known to be caused by mutations in multiple genes,there ar...
关键词：AFG3L2 gene autosomal recessive spinocerebellar ataxia mitochondrial impairment Ca2+overload 
Plant abiotic stress response and nutrient use efficiency被引量：137
《Science China(Life Sciences)》2020年第5期635-674,共40页Zhizhong Gong Liming Xiong Huazhong Shi Shuhua Yang Luis R.Herrera-Estrella Guohua Xu Dai-Yin Chao Jingrui Li Peng-Yun Wang Feng Qin Jigang Li Yanglin Ding Yiting Shi Yu Wang Yongqing Yang Yan Guo Jian-Kang Zhu 
Abiotic stresses and soil nutrient limitations are major environmental conditions that reduce plant growth,productivity and quality.Plants have evolved mechanisms to perceive these environmental challenges,transmit th...
关键词：abiotic stress sensing nutrient use efficiency heavy metal Ca2+signaling ROS signal transduction PHOSPHORYLATION transcription factor TRANSPORTER 
Synaptobrevin-2 facilitates the trafficking and function of atrial SK2 channel被引量：1
《Science China(Life Sciences)》2018年第5期599-603,共5页Tao Li Xuehui Fan Yiyan Yu Linlin Chen Wenjun Huang Yan Yang Jimin Cao Xiaorong Zeng Xiaoqiu Tan 
supported by the National Natural Science Foundation of China (30870903 to Xiaorong Zeng, 31300948,81670130 to Xiaoqiu Tan, 81670313 to Jimin Cao);Science and Technology Support Program of Sichuan Province (2011FZ0106 to Xiaorong Zeng)
Dear Editor,Small conductance Ca2＋-activated potassium （SK） channels are widely expressed in various tissues and play a unique role in regulating cell function by integrating cytosolic Ca2＋ levels and membrane pot...
关键词：隧道 CA2+ 
Mitochondrial Ca^(2+) uptake in skeletal muscle health and disease被引量：4
《Science China(Life Sciences)》2016年第8期770-776,共7页Jingsong Zhou Kamal Dhakal Jianxun Yi 
supported by National Institute of Arthritis and Musculoskeletal and Skin Diseases(NIAMS)/National Institutes of Health(NIH)Grant(R01 AR057404)to Jingsong Zhou
Muscle uses Ca2＋ as a messenger to control contraction and relies on ATP to maintain the intracellular Ca2＋ homeostasis. Mi- tochondria are the major sub-cellular organelle of ATP production. With a negative inner m...
关键词：skeletal muscle MITOCHONDRIA CA2+ 
Optopharmacological control of TRPC channels by coumarin-caged lipids is associated with a phototoxic membrane effect被引量：1
《Science China(Life Sciences)》2016年第8期802-810,共9页Oleksandra Tiapko Bernadett Bacsa Gema Guedes de la Cruz Toma Glasnov Klaus Groschner 
supported by the Austrian Science Fund(FWFW 1226-B18)
Photouncaging of second messengers has been successfully employed to gain mechanistic insight of cellular signaling path- ways. One of the most enigmatic processes of ion channel regulation is lipid recognition and li...
关键词：caged diacylglycerols TRPC channels Ca2+ signaling optopharmacology 
Expression and reconstitution of the bioluminescent Ca2+reporter aequorin in human embryonic stem cells,and exploration of the presence of functional IP3 and ryanodine receptors during the early stages of their differentiation into cardiomyocytes被引量：5
《Science China(Life Sciences)》2016年第8期811-824,共14页Harvey Y.S.Chan Man Chun Cheung Yi Gao Andrew L.Miller Sarah E.Webb 
supported by the Hong Kong Theme-based Research Scheme award(T13-706/11-1);the Hong Kong Research Grants Council(RGC)General Research Fund awards(662113,16101714,16100115);the ANR/RGC joint research scheme award(A-HKUST601/13);the Innovation and Technology Commission(ITCPD/17-9);supported by a Hong Kong University Grants Council post-graduate studentship(T13-706/11-11PG)
In order to develop a novel method of visualizing possible Ca2＋ signaling during the early differentiation of hESCs into cardi- omyocytes and avoid some of the inherent problems associated with using fluorescent repo...
关键词：Ca2+ signaling apo-aequorin expression bioluminescence HES2 human embryonic stem cells hESC-derived cardiospheres IP3 and ryanodine receptors 
The calcium sensing receptor: from calcium sensing to signaling被引量：17
《Science China(Life Sciences)》2015年第1期14-27,共14页ZHANG Chen MILLER Cassandra Lynn BROWN Edward M YANG Jenny J. 
supported by the US National Institutes of Health(GM081749 and EB007268);a Center for Diagnostics and Therapeutics fellowship(to Zhang Chen);funds from the Georgia Research Alliance
The Ca2+-sensing receptor(the Ca SR),a G-protein-coupled receptor,regulates Ca2+ homeostasis in the body by monitoring extracellular levels of Ca2+([Ca2+]o) and responding to a diverse array of stimuli.Mutations in th...
关键词：the Ca2＋-sensing receptor（the Ca SR） Ca2＋ signaling extracellular domain（ECD） Ca2＋-binding sites 
Canonical transient receptor potential 4 and its small molecule modulators被引量：4
《Science China(Life Sciences)》2015年第1期39-47,共9页FU Jie GAO ZhaoBing SHEN Bing ZHU Michael X. 
supported in part by the National Natural Science Foundation of China(81228021);US National Institutes of Health(DK081654)
Canonical transient receptor potential 4(TRPC4) forms non-selective cation channels that contribute to phospholipase C-dependent Ca2+ entry into cells following stimulation of G protein coupled receptors and receptor ...
关键词：TRPC4 channel non-selective cation channel G protein coupled receptors small molecular modulators G proteins EXCITATION CONTRACTION Ca2＋ signaling 
Open Sesame: treasure in store-operated calcium entry pathway for cancer therapy被引量：6
《Science China(Life Sciences)》2015年第1期48-53,共6页PAN Zui MA JianJie 
Store-operated Ca2+ entry(SOCE) controls intracellular Ca2+ homeostasis and regulates a wide range of cellular events including proliferation,migration and invasion.The discovery of STIM proteins as Ca2+ sensors and O...
关键词：Orai1 STIM1 Ca2＋ oscillations PROLIFERATION METASTASIS oncogenic 
Membrane protein reconstitution for functional and structural studies被引量：5
《Science China(Life Sciences)》2015年第1期66-74,共9页WANG LiGuo TONGGU LiGe 
supported by US National Institutes of Health(R01GM096458)to Wang LiGuo
Membrane proteins are involved in various critical biological processes,and studying membrane proteins represents a major challenge in protein biochemistry.As shown by both structural and functional studies,the membra...
关键词：membrane protein RECONSTITUTION Ca2＋ signaling Ca2＋ mediators Ca2＋-regulated enzymes Ca2＋ transducers 
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