CORTICAL_NEURONS

作品数：91被引量：300H指数：9
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相关作者：开丽薛春生王中峰华田苗化国鹏更多>>
相关机构：第三军医大学天津医科大学中国科学院上海生命科学研究院重庆医科大学更多>>
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Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice
《Neural Regeneration Research》2025年第8期2348-2360,共13页Mohamed Aghyad Al Kabbani Christoph Köhler Hans Zempel 
supported by the Koeln Fortune Program/Faculty of Medicine,University of Cologne,the Alzheimer Forschung Initiative e.V.(grant#22039,to HZ);open-access funding from the DFG/GRC issued to the University of Cologne;Alzheimer Forschung Initiative e.V.for Open Access Publishing(a publication grant#P2401,to MAAK)。
TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the axon.TAU is missorted and aggregated in an array of diseases known as tauopathies.Microtubules are essential for neuronal...
关键词：human induced pluripotent stem cell MICROTUBULES P301L pR5 mice TAU TAUOPATHY tubulin code 
Transforming growth factor-beta 1 enhances discharge activity of cortical neurons
《Neural Regeneration Research》2025年第2期548-556,共9页Zhihui Ren Tian Li Xueer Liu Zelin Zhang Xiaoxuan Chen Weiqiang Chen Kangsheng Li Jiangtao Sheng 
supported by the Natural Science Foundation of Guangdong Province,Nos.2019A1515010649(to WC),2022A1515012044(to JS);the China Postdoctoral Science Foundation,No.2018M633091(to JS).
Transforming growth factor-beta 1(TGF-β1)has been extensively studied for its pleiotropic effects on central nervous system diseases.The neuroprotective or neurotoxic effects of TGF-β1 in specific brain areas may de...
关键词：central nervous system cortical neurons ERK firing properties JNK Nav1.3 p38 transforming growth factor-beta 1 traumatic brain injury voltage-gated sodium currents 
Silencing miRNA-324-3p protects against cerebral ischemic injury via regulation of the GATA2/A1R axis被引量：3
《Neural Regeneration Research》2022年第11期2504-2511,共8页An-Qi Zhang Lu Wang Yi-Xiu Wang Shan-Shan Hong Yu-Shan Zhong Ru-Yi Yu Xin-Lu Wu Bing-Bing Zhou Qi-Min Yu Hai-Feng Fu Shuang-Dong Chen Yun-Chang Mo Qin-Xue Dai Jun-Lu Wang 
funded by the National Natural Science Foundation of China,No.81803937(to YCM and QXD);Science and Technology Innovation Activity Plan for College Students of Zhejiang Province(Xinmiao Talent Plan),No.2020R413079(to AQZ);Wenzhou Science and Technology Plan Project,No.Y20210122(to QXD)。
Previous studies have suggested that miR-324-3p is related to the pathophysiology of cerebral ischemia,but the mechanism underlying this relationship is unclea r.In this study,we found that miR-324-3p expression was d...
关键词：acute ischemic stroke adenosine A1 receptor apoptosis cerebral ischemia-reperfusion injury cortical neurons GATA2 middle cerebral artery occlusion miR-324-3p oxygen-glucose deprivation/reoxygenation PC12 cells 
Differential development and electrophysiological activity in cultured cortical neurons from the mouse and cynomolgus monkey
《Neural Regeneration Research》2021年第12期2446-2452,共7页Xue-Yan Zhang Jun Li Cai-Juan Li Ying-Qi Lin Chun-Hui Huang Xiao Zheng Xi-Chen Song Zhu-Chi Tu Xiao-Jiang Li Sen Yan 
This work was supported by the National Natural Science Foundation of China,No.81922026(to SY);the National Key Research and Development Program of China Stem Cell and Translational Research,No.2017YFA0105104(to SY);Key Field Research and Development Program of Guangdong Province,No.2018B030337001(to XJL);Guangdong Key Laboratory of Non-human Primate Models of Brain Diseases,No.2020B121201006(to XJL);Guangzhou Key Research Program on Brain Science,No.202007030008(to SY);the Fundamental Research Funds for the Central Universities,No.21619104(to SY).
In vitro cultures of primary cortical neurons are widely used to investigate neuronal function.However,it has yet to be fully investigated whether there are significant differences in development and function between ...
关键词：Axion-MEA electrical activities human disease model Huntington’s disease HTT monkey neuron morphometric analysis mouse neuron neurodegenerative diseases primary culture 
Exosomes derived from human induced pluripotent stem cell-derived neural progenitor cells protect neuronal function under ischemic conditions被引量：4
《Neural Regeneration Research》2021年第10期2064-2070,共7页Wen-Yu Li Qiong-Bin Zhu Lu-Ya Jin Yi Yang Xiao-Yan Xu Xing-Yue Hu 
This work was supported by the Foundation of Zhejiang Provincial Basic Public Welfare Research Program of China,No.LGF19H090024(to XYX);the Natural Science Foundation of Zhejiang Province of China,No.LY17H090006(to WYL);National Natural Science foundation of China,No.81901073(to QBZ).
Compared with other stem cells,human induced pluripotent stem cells-derived neural progenitor cells(iPSC-NPCs)are more similar to cortical neurons in morphology and immunohistochemistry.Thus,they have greater potentia...
关键词：AKT cortical neurons EXOSOME ISCHEMIA neural progenitor cells neuronal protection oxygen and glucose deprivation pluripotent stem cells PTEN signaling pathway 
Corrigendum: Silencing Huwe1 reduces apoptosis of cortical neurons exposed to oxygen-glucose deprivation and reperfusion
《Neural Regeneration Research》2021年第3期530-530,共1页
In the article titled“Silencing Huwe1 reduces apoptosis of cortical neurons exposed to oxygen-glucose deprivation and reperfusion”,published on pages 1977–1985,Issue 11,Volume 14 of Neural Regeneration Research(He ...
关键词：REPERFUSION DEPRIVATION FIGURE 
Neuroprotective effect of deferoxamine on erastin-induced ferroptosis in primary cortical neurons被引量：11
《Neural Regeneration Research》2020年第8期1539-1545,共7页Yan Zhang Bao-You Fan Yi-Lin Pang Wen-Yuan Shen Xu Wang Chen-Xi Zhao Wen-Xiang Li Chang Liu Xiao-Hong Kong Guang-Zhi Ning Shi-Qing Feng Xue Yao 
supported by the National Natural Science Foundation of China,Nos.81672171(to XY),81620108018(to SQF),81772342(to GZN);the State Key Laboratory of Medicinal Chemical Biology of Nankai University of China,No.2017027(to XY)
The iron chelator deferoxamine has been shown to inhibit ferroptosis in spinal cord injury.However,it is unclear whether deferoxamine directly protects neurons from ferroptotic cell death.By comparing the survival rat...
关键词：cystine/glutamate antiporter system light chain DEFEROXAMINE erastin ferroptosis glutathione peroxidase 4 neurons NEUROPROTECTION reactive oxygen species 
Rabs and axonal regeneration
《Neural Regeneration Research》2019年第4期566-569,共4页Cheryl Qian Ying Yong Bor Luen Tang 
supported by the National University of Singapore Graduate School for Integrative Sciences and Engineering(to BLT)
Membrane trafficking processes are presumably vital for axonal regeneration after injury, but mechanistic understanding in this regard has been sparse. A recent loss-of-function screen had been carried out for factors...
关键词：ARF RAB Rab27b axon regeneration axonal transport cortical neurons central nervous system injury membrane trafficking Myosin-Ⅴ 
Mitochondrial division inhibitor 1 protects cortical neurons from excitotoxicity:a mechanistic pathway被引量：2
《Neural Regeneration Research》2018年第9期1552-1560,共9页Kuai Zhou Hai-Yuan Yang Peng-Yu Tang Wei Liu Yong-Jun Luo Bin Lv Jian Yin Tao Jiang Jian Chen Wei-Hua Cai Jin Fan 
supported by the National Natural Science Foundation of China,No.81371967 and 81401807;a grant from the 5th Phase of "Project 333"of Jiangsu Province of China,No.BRA2016512;a grant from the Six Talent Peaks Project of Jiangsu Province of China,No.2014-WSN-012
Mitochondrial division inhibitor 1（Mdivi-1） is a selective cell-permeable inhibitor of dynamin-related protein-1（Drp1） and mitochondrial division.To investigate the effect of Mdivi-1 on cells treated with glutamat...
关键词：nerve regeneration mitochondrial division inhibitor 1 neurons apoptosis mitochondria division dynamin-related protein-I phospho-dynamin-related protein-1 Bax GLUTAMATE COLOCALIZATION neural regeneration 
Electrical stimulation of cortical neurons promotes oligodendrocyte development and remyelination in the injured spinal cord被引量：1
《Neural Regeneration Research》2017年第10期1613-1615,共3页Dan C.Li Qun Li 
Background and early studies： Endogenous tri-potential neural stem cells （NSCs） exist in the adult mammalian central nervous system （CNS）. In the spinal cord, NSCs distribute throughout the entire cord, but exist...
关键词：OPC CNS Electrical stimulation of cortical neurons promotes oligodendrocyte development and remyelination in the injured spinal cord 
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