DEGENERATION

作品数：521被引量：1030H指数：13
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相关作者：施杞梁倩倩王拥军侯炜崔学军更多>>
相关机构：上海中医药大学复旦大学青岛大学华中科技大学更多>>
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Osteopontin deficiency promotes cartilaginous endplate degeneration by enhancing the NF-κB signaling to recruit macrophages and activate the NLRP3 inflammasome
《Bone Research》2024年第4期846-862,共17页Yanqiu Wang Wanqian Zhang Yi Yang Jinghao Qin Ruoyu Wang Shuai Wang Wenjuan Fu Qin Niu Yanxia Wang Changqing Li Hongli Li Yue Zhou Minghan Liu 
supported by Chongqing Municipal Natural Science Foundation (CSTB2022NSCQ-MSX1366);National Natural Science Foundation of China (81702182,81874087);Chongqing Outstanding Young Talent Supporting Program (cstc2024ycjhbgzxm0031);the Special Project for Talent Development of Xinqiao Hospital (2022XKRC006)。
Intervertebral disc degeneration(IDD)is a major cause of discogenic pain,and is attributed to the dysfunction of nucleus pulposus,annulus fibrosus,and cartilaginous endplate(CEP).Osteopontin(OPN),a glycoprotein,is hig...
关键词：NLRP3 DEGENERATION homeostasis 
KMT2A regulates the autophagy-GATA4 axis through METTL3-mediated m^(6)A modification of ATG4a to promote NPCs senescence and IVDD progression
《Bone Research》2024年第4期1031-1048,共18页Ouqiang Wu Yuxin Jin Zhiguang Zhang Hao Zhou Wenbin Xu Linjie Chen Morgan Jones Kenny Yat Hong Kwan Jianyuan Gao Kai Zhang Xiaofei Cheng Qizhu Chen Xinzhou Wang Yan Michael Li Zhenyu Guo Jing Sun Zhihua Chen Bin Wang Xiangyang Wang Shuying Shen Aimin Wu 
supported by the National Natural Science Foundation of China (82272555,82272522,82422044,82101647);Zhejiang Provincial Natural Science Foundation of China (LGF21H060010,LR22H060001,LY23H060011);Wenzhou Major Scientific and Technological Innovation Project (ZY2022010);Zhejiang Provincial Medical Technology Foundation of China (2022PY071)。
Intervertebral disc degeneration(IVDD),a disease associated with ageing,is characterised by a notable increase in senescent nucleus pulposus cells(NPCs)as IVDD progresses.However,the specific mechanisms that regulate ...
关键词：NPCs IMPAIRED DEGENERATION 
Lumbar instability remodels cartilage endplate to induce intervertebral disc degeneration by recruiting osteoclasts via Hippo-CCL3 signaling被引量：1
《Bone Research》2024年第3期555-570,共16页Hanwen Li Yingchuang Tang Zixiang Liu Kangwu Chen Kai Zhang Sihan Hu Chun Pan Huilin Yang Bin Li Hao Chen 
supported by National Natural Science Foundation of China (82172468,82372436 and 32301416);Natural Science Foundation of Jiangsu Province (BK20211326);Natural Science Fund for Colleges and Universities in Jiangsu Province (21KJB320009)。
Degenerated endplate appears with cheese-like morphology and sensory innervation,contributing to low back pain and subsequently inducing intervertebral disc degeneration in the aged population.1 However,the origin and...
关键词：DEGENERATION CARTILAGE INTERVERTEBRAL 
A new perspective on intervertebral disc calcification—from bench to bedside被引量：1
《Bone Research》2024年第1期50-61,共12页Emanuel J.Novais Rajkishen Narayanan Jose A.Canseco Koen van de Wetering Christopher K.Kepler Alan S.Hilibrand Alexander R.Vaccaro Makarand V.Risbud 
support by R01AR055655, R01AR074813, and R01AG073349 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and the National Institute on Aging (NIA);supported by PXE International.
Disc degeneration primarily contributes to chronic low back and neck pain.Consequently,there is an urgent need to understand the spectrum of disc degeneration phenotypes such as fibrosis,ectopic calcification,herniati...
关键词：DEGENERATION metabolism INTERVERTEBRAL 
Low back pain and osteoarthritis pain:a perspective of estrogen被引量：2
《Bone Research》2023年第3期443-456,共14页Huiwen Pang Shihui Chen David M.Klyne David Harrich Wenyuan Ding Sidong Yang Felicity Y.Han 
supported by the Natural Science Foundation of China (No.81871800 and 82072496)granted to W.D.;the Natural Science Foundation of Hebei Province (No.H2020206203)granted to S.Y.;a National Health and Medical Research Council (NHMRC)Australia Ideas Grant (No.2011398) granted to D.H.;supported by the Assistant Secretary of Defense for Health Affairs endorsed by the US Department of Defense through the FY19 Chronic Pain Management Research Program (D.M.K:award no.W81XWH2010909)。
Low back pain(LBP)is the world's leading cause of disability and is increasing in prevalence more rapidly than any other pain condition.Intervertebral disc(IVD)degeneration and facet joint osteoarthritis(FJOA)are two ...
关键词：AGENT DEGENERATION PAIN 
Upregulation of β-catenin signaling represents a single common pathway leading to the various phenotypes of spinal degeneration and pain被引量：2
《Bone Research》2023年第2期316-327,共12页Ke Lu Qingyun Wang Hua Jiang Jun Li Zhou Yao Yongcan Huang Jianquan Chen Yejia Zhang Guozhi Xiao Xueyu Hu Zhuojing Luo Liu Yang Liping Tong Di Chen 
supported by the National Key Research and Development Program of China(2021YFB3800800)to L.T.and D.C.;supported by the National Natural Science Foundation of China(NSFC)grants 82030067,82161160342,and 82250710174 to D.C.;NSFC grant 82172397 to L.T.;supported by the Chinese Postdoctoral Science Foundation(2022M710158)。
Spine degeneration is an aging-related disease,but its molecular mechanisms remain unknown,although elevatedβ-catenin signaling has been reported to be involved in intervertebral disc degeneration.Here,we determined ...
关键词：DEGENERATION smallest HOMEOSTASIS 
Endothelial PDGF-BB/PDGFR-βsignaling promotes osteoarthritis by enhancing angiogenesis-dependent abnormal subchondral bone formation被引量：15
《Bone Research》2022年第4期852-866,共15页Zhuang Cui Hangtian Wu Ye Xiao Ting Xu Junjie Jia Hancheng Lin Rongmin Lin Kun Chen Yihuang Lin Kaiqun Li Xiaohu Wu Changjun Li Bin Yu 
This study was supported by the Natural Science Foundation of Guangdong Province,China(2019A1515011614 to ZC);the Science and Technology Program of Guangzhou(202002030483 to ZC);the National Natural Science Foundation of China(81601942 to ZC and 81830079 to BY);the Outstanding Youths Development Scheme of Southern Medical University(2021YQPY008 to ZC);the National Key R&D Program of China(2019YFA0111900 to CL).
The mechanisms that coordinate the shift from joint homeostasis to osteoarthritis(OA)remain unknown.No pharmacological intervention can currently prevent the progression of osteoarthritis.Accumulating evidence has sho...
关键词：DEGENERATION OSTEOARTHRITIS ANGIOGENESIS 
Restoring the dampened expression of the core clock molecule BMAL1 protects against compression-induced intervertebral disc degeneration被引量：6
《Bone Research》2022年第2期297-309,共13页Dong Wang Pandi Peng Michal Dudek Xueyu Hu Xiaolong Xu Qiliang Shang Di Wang Haoruo Jia Han Wang Bo Gao Chao Zheng Jianxin Mao Chu Gao Xin He Pengzhen Cheng Huanbo Wang Jianmin Zheng Judith A.Hoyland Qing-Jun Meng Zhuojing Luo Liu Yang 
the National Natural Science Foundation of China(82020108019,82130070,81730065,82002347,81972032,and 81902202);The Medical Research Council(UK)MR/T016744/1 and MR/P010709/1;the Versus Arthritis Senior Research Fellowship Award 20875.
The circadian clock participates in maintaining homeostasis in peripheral tissues,including intervertebral discs(IVDs).Abnormal mechanical loading is a known risk factor for intervertebral disc degeneration(IDD).Based...
关键词：BMAL1 DEGENERATION HOMEOSTASIS 
Inhibition of aberrant Hif1αactivation delays intervertebral disc degeneration in adult mice被引量：2
《Bone Research》2022年第1期65-80,共16页Zuqiang Wang Hangang Chen Qiaoyan Tan Junlan Huang Siru Zhou Fengtao Luo Dali Zhang Jing Yang Can Li Bo Chen Xianding Sun Liang Kuang Wanling Jiang Zhenhong Ni Quan Wang Shuai Chen Xiaolan Du Di Chen Chuxia Deng Liangjun Yin Lin Chen Yangli Xie 
supported by grants from the National Key Research and Development Program of China (2018YFA0800802);the National Natural Science Foundation of China (81830075, 81772306, 81530071, and 81991513);the Chongqing Talent Plan (CQYC202001008 and CQYC202005088)
The intervertebral disc(IVD) is the largest avascular tissue. Hypoxia-inducible factors(HIFs) play essential roles in regulating cellular adaptation in the IVD under physiological conditions. Disc degeneration disease...
关键词：HIF1Α DEGENERATION ABERRANT 
3D assessment of intervertebral disc degeneration in zebrafish identifies changes in bone density that prime disc disease被引量：4
《Bone Research》2021年第4期521-536,共16页Erika Kague Francesco Turci Elis Newman Yushi Yang Kate Robson Brown Mona S.Aglan Ghada A.Otaify Sarnia A.Temtamy Victor L.Ruiz-Perez Stephen Cross C.Patrick Royall P.Eckhard Witten Chrissy L.Hammond 
Back pain is a common condition with a high social impact and represents a global health burden.Intervertebral disc disease(IVDD)is one of the major causes of back pain;no therapeutics are currently available to rever...
关键词：INTERVERTEBRAL DEGENERATION protective 
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