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作品数：80被引量：267H指数：9
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相关领域：医药卫生生物学更多>>
相关作者：郭岩康业斌张强周韧刘永军更多>>
相关机构：浙江大学洛阳农业高等专科学校浙江大学医学院附属第二医院浙江中医药大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金中国博士后科学基金更多>>
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Potential role of tanycyte-derived neurogenesis in Alzheimer's disease
《Neural Regeneration Research》2025年第6期1599-1612,共14页Guibo Qi Han Tang Jianian Hu Siying Kang Song Qin 
supported by the National Natural Science Foundation of China,Nos.31871477,32170971 (both to SQ);the Qing-Feng Scholar Research Foundation of Shanghai Medical College,Fudan University,No.QF2212 (to HT)。
Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance. T...
关键词：Alzheimer's disease blood–brain barrier ependymoglial cells HYPOTHALAMUS metabolic diseases neural stem cells NEUROGENESIS neuroinflammatory diseases NEURONS TANYCYTE 
Temperature-sensitive hydrogel inhibits VEGFA-dependent neovascularization in atherosclerosis progression
《Science China Materials》2025年第1期280-291,共12页Yi Duan Jiangtao Lin Jiang Yue Yuanyuan Li Jinghan Liao Ying Sun Quan Wang Yourong Duan Zhaojun Li 
National Natural Science Foundation of China (81972886 and 82172736);Shanghai Health and Family Planning Commission Fund (202240235);Natural Science Foundation of Shanghai (21ZR1451400);Shanghai Jiading District Health and Family Planning Commission Fund (2021-KY-10)。
Atherosclerosis remains a major cause of morbidity and mortality worldwide.Intraplaque neovascularization critically promotes atherosclerotic progression and instability.Vascular endothelial growth factor A(VEGFA)stim...
关键词：vascular endothelial growth factor A NEOVASCULARIZATION advanced atherosclerosis thermosensitive hydrogel ultrasound 
ADP-Hep-Induced Liquid Phase Condensation of TIFA-TRAF6 Activates ALPK1/TIFA-Dependent Innate Immune Responses
《Research》2024年第4期205-221,共17页Liping Li Jia Wang Xincheng Zhong Yaoyao Jiang Gaofeng Pei Xikang Yang Kaixiang Zhang Siqi Shen Xue Jin Gaoge Sun Chaofei Su Shuzhen Chen Hang Yin 
supported by the National Natural Science Foundation of China(Grant Nos.21825702 and 22137004);Beijing Outstanding Young Scientist Program(Grant No.BJJWZYJH01201910003013);Tsinghua University Initiative Scientific Research Program of Precision Medicine(10001020105).
The ALPK1(alpha-kinase 1)-TIFA(TRAF-interacting protein with fork head-associated domain)-TRAF6 signaling pathway plays a pivotal role in regulating inflammatory processes,with TIFA and TRAF6 serving as key molecules ...
关键词：PENDENT INCOMPLETE separation 
Monitor and Acceptance among Couples in Romantic Relationships:Actor-Partner Interdependence Models Based on the Monitor and Acceptance Theory
《International Journal of Mental Health Promotion》2024年第7期589-598,共10页Xue Wen Yuyang Zhou Jiaxuan Du Xiaoyan Liu Wei Xu 
supported by the National Natura Science Foundation of China(Grant Number:31800929);Fundamental Research Funds for Central Universities(Grant Number:2020NTSS42).
Communication could be an essential part of couples in their daily life.Based on Monitor and Acceptance Theory(MAT),the present study explored the mediating role of communication in the relationship between mindfulnes...
关键词：Romantic relationship communication MINDFULNESS MONITOR ACCEPTANCE 
Eugenol suppresses VEGF-dependent angiogenesis by JAK2/STAT3 pathway in non-small cell lung cancer
《Guideline and Standard in Chinese Medicine》2024年第2期80-90,共11页Yifan Su Yurong Wang Qian Yu Zhijian Wu Dawei Zhang Chunyan Yan 
funded by the National Natural Science Foundation of China(No.81973454);the Guangzhou Science and Technology Plan Project(No.202102020312).
Background:Non-small cell lung cancer(NSCLC)is a highly vascularized solid tumor,and tumor angiogenesis is closely associated with the metastasis and progression of NSCLC.Antiangiogenic drugs can target the tumor micr...
关键词：EUGENOL ANGIOGENESIS non-small cell lung cancer JAK2/STAT3 
STAT3-Dependent Effects of Polymeric Immunoglobulin Receptor in Regulating Interleukin-17 Signaling and Preventing Autoimmune Hepatitis
《Engineering》2024年第5期209-222,共14页Ting Li Tongtong Pan Nannan Zheng Xiong Ma Xiaodong Wang Fang Yan Huimian Jiang Yuxin Wang Hongwei Lin Jing Lin Huadong Zhang Jia Huang Lingming Kong Anmin Huang Qingxiu Liu Yongping Chen Dazhi Chen 
supported by the National Natural Science Foundation of China(82070593);the Zhejiang Provincial Natural Science Foundation(LD21H030002);the Department of Science and Technology of Zhejiang Province(ZY2019008);the Youth Program of the National Natural Science Foundation of China(82200632).
One-third of patients with autoimmune hepatitis(AIH)have cirrhosis at the time of diagnosis.The relevance of these variables,although unknown,is believed to be critical in AIH because of suspected interactions between...
关键词：Autoimmune hepatitis Polymeric immunoglobulin receptor Regenerating islet-derived 3 beta Intestinal microbiota Signal transducer and activator of transcription 3 
LncRNA LOC103694972 promotes fibrosis of NRK-49F cells by regulating STAT3-dependent Smad/CTGF pathway via targeting miR-29c-3p
《BIOCELL》2024年第3期501-511,共11页YAN LI HUZHI CAI XIAOLING PENG YOUHUI LIU QINGYANG CHEN XIANGDONG LIN XINYU CHEN 
This work was supported by the Hunan Provincial Education Department General Project Research Fund(No.20C1412);the Hunan Graduate Scientific Research Innovation Project(No.CX2018B474);the National Famous Elderly Chinese Medicine Experts Xinyu Chen Inheritance Workshop Construction Project(No.[2022]75).
Background:Renalfibrosis is an important process in the development of chronic kidney disease.Understanding the pathogenesis andfinding effective treatments for renalfibrosis is crucial.This study aims to investigate whe...
关键词：Renal fibrosis lncRNA LOC103694972 lncRNA Chip miR-29c-3p STAT3-Smad3/CTGF 
Disulfiram ameliorates STING/MITA-dependent inflammation and autoimmunity by targeting RNF115
《Cellular & Molecular Immunology》2024年第3期275-291,共17页Zhi-Dong Zhang Chang-Rui Shi Fang-Xu Li Hu Gan Yanhong Wei Qianhui Zhang Xin Shuai Min Chen Yu-Lin Lin Tian-Chen Xiong Xiaoqi Chen Bo Zhong Dandan Lin 
supported by grants from the National Key Research and Development Program of China(Grant Nos.2022YFC3401500 and 2023YFC2306100);the Natural Science Foundation of China(Grant Nos.31930040,32070900,82000670,32270951,32200710,and 823B1006);the Fundamental Research Funds for the Central Universities(Grant Nos.2042022kf1187,2042022kf1123 and 2042022dx0003);the Major Scientific and Technological Project of Hubei Province(Grant No.2022ACA005);the Translational Medicine and Interdisciplinary Research Joint Found of Zhongnan Hospital of Wuhan University(Grant.No.ZNJC202218);the Non-Profit Central Research Institute Fund of the Chinese Academy of Medical Sciences(Grant No.2020PT320-004).
STING(also known as MITA)is an adaptor protein that mediates cytoplasmic DNA-triggered signaling,and aberrant activation of STING/MITA by cytosolic self-DNA or gain-of-function mutations causes severe inflammation.Her...
关键词：STING/MITA DISULFIRAM RNF115 SLE AUTOIMMUNITY 
Germ cell-specific deletion of Pex3 reveals essential roles of PEX3-dependent peroxisomes in spermiogenesis
《The Journal of Biomedical Research》2024年第1期24-36,共13页Yejin Yao Baolu Shi Xiangzheng Zhang Xin Wang Shuangyue Li Ying Yao Yueshuai Guo Dingdong Chen Bing Wang Yan Yuan Jiahao Sha Xuejiang Guo 
supported by grants from the National Natural Science Foundation of China(Grant No.31890784 to J.S.);National Key R&D Program(Grant No.2021YFC2700200 to X.G.);National Natural Science Foundation of China(Grant Nos.92068109 and 82122025 to Yan Yuan);Natural Science Foundation of the Jiangsu Higher Education Institutions of China(Grant No.21KJA310007 to Yan Yuan);Science Foundation of Gusu School(Grant No.GSKY20220101 to J.S.).
Peroxisomes are organelles enclosed by a single membrane and are present in various species.The abruption of peroxisomes is correlated with peroxisome biogenesis disorders and single peroxisomal enzyme deficiencies th...
关键词：male infertility SPERMIOGENESIS PEROXISOME oxidative stress PEX3 
ATIP/ATIP1 regulates prostate cancer metastasis through mitochondrial dynamic-dependent signaling
《Acta Biochimica et Biophysica Sinica》2024年第2期304-314,共11页Haokun Yuan Ruiqin Fang Chi Fu Shuo Wang Xiaoqin Tong Deyi Feng Xiaoqing Wei Xirong Hu Yuan Wang 
This work was supported by the grants from the Department of Science and Technology of Sichuan Province(Nos.2021ZYD0092 and 2022NSFSc0721);the Fundamental Research Funds for the Central Universities(Nos.ZYGX2021J024 and Y030222059002005).
Mitochondria play a fundamental role in cell survival and motility.Abnormalities in mitochondria are associated with carcinogenesis,especially with tumor metastasis.In this study,we explore the biological function of ...
关键词：ATIP/ATIP1 Drp1 mitochondrial dynamics METASTASIS 
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