GASTRIC_CANCER_CELL

作品数：134被引量：748H指数：14
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RNA-binding motif protein RBM39 enhances the proliferation of gastric cancer cells by facilitating an oncogenic splicing switch in MRPL33
《Acta Pharmacologica Sinica》2025年第4期1068-1081,共14页Cheng-piao Lu Jia-bin Li Dong-bao Li Yu-hong Wang Xiao-gang Jiang Jing-jing Ma Guoqiang Xu 
supported by the National Natural Science Foundation of China(32171437);the National Key R&D Program of China(2019YFA0802401);the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(22KJB310017);Suzhou Science and Technology Development Project(SZM2023006);Gusu Key Health Talent Program of Suzhou(GSWS2022122);the Young Physician Scientists Program(ML42900323);Interdisciplinary Basic Frontier Innovation Program(YXY2302015)at Suzhou Medical College of Soochow University;the National Center for International Research(2017B01012);the Jiangsu Key Laboratory of Neuropsychiatric Diseases(BM2013003);a project funded by the Priority Academic Program Development(PAPD)of Jiangsu Higher Education Institutions.
Gastric cancer is a malignant gastrointestinal disease characterized by high morbidity and mortality rates worldwide.The occurrence and progression of gastric cancer are influenced by various factors,including the abn...
关键词：RBM39 MRPL33 gastric cancer PROLIFERATION alternative splicing 
DNMT1 promotes the proliferation and migration of gastric cancer cells by inducing microRNA-125a-5p methylation to promote SERPINE1 protein
《World Journal of Gastrointestinal Oncology》2025年第3期188-201,共14页Hui Xie Hui Wang Ru-Hong Li Yue-Wen Zhang Xi-Rui Fan Xiao-Xue He Ao-Ran Guan 
the Research Program of the Science and Technology Department of Yunnan Province,No.202101AY070001-204.
BACKGROUND Gastric cancer(GC)is a malignant tumor originating from gastric mucosal epithelial cells that has high morbidity and mortality.microRNAs(miR)are important diagnostic markers and therapeutic targets in this ...
关键词：Gastric cancer microRNA-125a-5p DNA methyltransferase 1 SERPINE1 METHYLATION 
MiR-340-5p affects the proliferation and transfer of gastric cancer cells by targeting lncRNA HCG11 and NRF2 expression
《Oncology and Translational Medicine》2025年第1期29-35,共7页Rina Su Wei Luan Kai Zhang Shuai Liu Xiaoqing Zhang Yanwei Gao 
Funded by the general program of the Nature Fund of InnerMongolia Autonomous Region.
Objective:The aim of the study was to investigate the expression and biological role of nuclear factor erythroid–related factor 2(NRF2)in gastric cancer cells.Methods:Western blotting(WB)and reverse transcription-pol...
关键词：Gastric cancer Nuclear factor erythroid 2 related factor 2(NRF2) Apoptosis COX-2/PEG 2 signaling pathway 
Investigation of the Cytotoxicity of CAR-NK-92 Cells Targeting CEA Against Gastric Cancer Cells
《Journal of Clinical and Nursing Research》2024年第6期410-416,共7页Xinyu Zheng Xiaoxiao Zhou Xingzhou Xia Xiaomeng Chen 
Henan Provincial Health Commission's 2020 National Health Commission Science Research Fund Henan Provincial Medical Science and Technology Tackling Plan Provincial-Ministerial Joint Project and Soft Science Project"Clinical Study of CAR-NK Cells Targeting Carcinoembryonic Antigen on Gastric Cancer Cells"(Grant No.SBGJ202002093);Henan Province 2022 Science and Technology Development Plan"Study on Pyroglutamate Targeting DJ-1 to Trigger ROS-Induced Cell Death and Protective Autophagy in Pancreatic Cancer"(Grant No.222102310725)。
Objective:To construct CAR-NK-92 cells targeting carcinoembryonic antigen(CEA)and study their killing effect on gastric cancer cells.Methods:CAR-NK-92 cells targeting CEA were constructed.After co-culturing CAR-NK-92 ...
关键词：Gastric cancer Natural killer cell Carcinoembryonic antigen IMMUNOTHERAPY 
The Epstein-Barr virus-miRNA-BART6-5p regulates TGF-β/SMAD4 pathway to induce glycolysis and enhance proliferation and metastasis of gastric cancer cells
《Oncology Research》2024年第5期999-1009,共11页XUHUI ZHAO XIAOMIN HUANG CHUNYAN DANG XIA WANG YUJIAO QI HONGLING LI 
supported by National Health Commission Key Laboratory of Gastrointestinal Tumour Diagnosis and Treatment 2022 Master/Postdoctoral Fund Project(NHCDP2022005);Gansu Provincial Science and Technology Department Joint Scientific Research Fund Project(23JRRA1545);Gansu Provincial Hospital Intra-Hospital Research Fund Project(22GSYYD-37);International Co-Operation Project of Gansu Provincial Science and Technology Department(No.20YF8WA096).
Background:EBV-miR-BARTs exhibit significant relevance in epithelial tumors,particularly in EBVassociated gastric and nasopharyngeal cancers.However,their specific mechanisms in the initiation and progression of gastr...
关键词：EBV TGF-β/SMAD4 GLYCOLYSIS Gastric cancer 
ZYX promotes invasion and metastasis of gastric cancer cells via WNK1/SNAI1axis
《Genes & Diseases》2024年第2期564-567,共4页Yi Jiang Dongfang Xiang Xianmei Wen Mingmin He Yan Qin Xiaoxue Yao Zexuan Yan Xiuli Geng Yong Ren Xiongwei Cai Youhong Cui Yan Wang 
supported by the Chongqing Academician Program(No.cstc2019yszx-jcyjx0008 to Y.W.);The Subject of Health Commission of Hubei Province,China(No.WJ2021M222 to X.-M.W.).
Gastric cancer(GC)is the third most common cause of cancer death globally and a large portion of patients are diagnosed at advanced stages with cancer invasion and metastasis1,2.However,the mechanisms underlying the i...
关键词：WNK1 INVASION METASTASIS 
Ellagic acid inhibits gastric cancer cells by modulating oxidative stress and inducing apoptosis
《Asian Pacific Journal of Tropical Biomedicine》2024年第4期162-169,共8页Jian Zheng Chun-Feng Li 
supported by the Heilongjiang Provincial Natural Science Foundation of China(LH2022H063).
Objective:To evaluate the anticancer effect of ellagic acid on gastric cancer cells.Methods:MTT assay was used to evaluate the effect of ellagic acid at different concentrations(0.5-100μg/mL)on gastric cancer AGS cel...
关键词：Ellagic acid Gastric cancer APOPTOSIS AUTOPHAGY METASTASIS Proliferation 
Mitochondrial carrier homolog 2 increases malignant phenotype of human gastric epithelial cells and promotes proliferation,invasion,and migration of gastric cancer cells
《World Journal of Gastrointestinal Oncology》2024年第3期991-1005,共15页Jing-Wen Zhang Ling-Yan Huang Ya-Ning Li Ying Tian Jia Yu Xiao-Fei Wang 
the Medical Science Research Projects in Hebei Province,No.20221526;and Natural Science Foundation,No.2022-271.
BACKGROUND The precise role of mitochondrial carrier homolog 2(MTCH2)in promoting malignancy in gastric mucosal cells and its involvement in gastric cancer cell metastasis have not been fully elucidated.AIM To determi...
关键词：Gastric cancer Mitochondrial carrier homolog 2 ATP synthase ATP2A2 Mitochondrial permeability transformation pore 
Immune-related long noncoding RNA zinc finger protein 710-AS1-201 promotes the metastasis and invasion of gastric cancer cells
《World Journal of Gastrointestinal Oncology》2024年第2期458-474,共17页Wei Ding Wei-Wei Chen Yi-Qin Wang Xue-Zhong Xu Yi-Bo Wang Yong-Min Yan Yu-Lin Tan 
Changzhou Sci and Tech Program,No.CJ20220008;Young Talent Development Plan of Changzhou Health Commission,No.CZQM2020118;Changzhou High-Level Medical Talents Training Project,No.2022CZBJ105;Cultivation Project of Changzhou Medical Center,Nanjing Medical University,No.CMCB202211;Development Foundation of Affiliated Hospital of Xuzhou Medical University,No.XYFC202304,and No.XYFM202307。
BACKGROUND Gastric cancer(GC)is a prevalent malignant tumor of the gastrointestinal system.ZNF710 is a transcription factor(TF),and zinc finger protein 710(ZNF710)-AS1-201 is an immune-related long noncoding RNA(lncRN...
关键词：Gastric cancer ZNF710-AS1-201 Proliferation METASTASIS INVASION Apoptosis 
PRMT1 promotes the proliferation and metastasis of gastric cancer cells by recruiting MLXIP for the transcriptional activation of theβ-catenin pathway被引量：1
《Genes & Diseases》2023年第6期2622-2638,共17页Feng Wang Shitong Chen Shihan Peng Xujun Zhou Houyi Tang Hanghua Liang Xi Zhong He Yang Xiaoxue Ke MuHan Lü Hongjuan Cui 
supported by the National Natural Science Foundation of China(No.82203339);the Postdoctoral Research Foundation of China(No.2021M692679);the Chongqing Postdoctoral Science Foundation(China)(No.7820100607);the Natural Science Foundation Project of Chongqing(China)(No.cstc2021jcyj-bsh0067 and cstc2022ycjh-bgzxm0145).
Protein arginine methyltransferase 1(PRMT1),a type I PRMT,is overexpressed in gastric cancer(GC)cells.To elucidate the function of PRMT1 in GC,PRMT1 expression in HGC-27 and MKN-45 cells was knocked down by short hair...
关键词：β-catenin signaling pathway Gastric cancer PRMT1 Transcriptional regulation UBIQUITINATION 
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