GENE_SILENCING

作品数：162被引量：627H指数：11
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Recent advances in DNAzyme-based gene silencing被引量：5
《Science China Chemistry》2017年第5期591-601,共11页Huanhuan Fan Xiaobing Zhang Yi Lu 
supported by the National Key Scientific Program of China(2011CB911000);the National Basic Research Program of China(2013CB932702);the National Natural Science Foundation of China(21325520,21327009,J1210040,21177036);the National Instrumentation Program(2011YQ030124);the Foundation for Innovative Research Groups of NSFC(21521063)
DNAzymes, generated through in vitro selection processes, are single-stranded DNA catalysts that can catalyze a wide variety of reactions, such as RNA or DNA cleavage and ligation or DNA phosphorylation. Based on spec...
关键词：DNAZYMES GENE-SILENCING delivery STABILITY COFACTORS 
Polylysine-modified Polyethylenimines as siRNA Carriers for Effective Tumor Treatment被引量：2
《Chinese Journal of Polymer Science》2015年第6期830-837,共8页Jie Chen Zi-xue Jiao Lin Lin Zhao-pei Guo Cai-na Xu Yan-hui Li 田华雨 Xue-si Chen 
financially supported by the National Natural Science Foundation of China(Nos.51222307,51303173,51390480,21474104 and 51403205);the Ministry of Science and Technology of China(International cooperation and communication program 2011DFR51090);Jilin Province Science and Technology Development Program(Nos.20120306,20130521011JH)
Polyethylenimine-poly（L-lysine） （PEI-PLL） copolymer was synthesized via ring-opening polymerization of L-lysine N-carboxyanhydride （Lys（Z）-NCA） initiated by PEI. The complexation of PEI-PLL with siRNA was stud...
关键词：Gene carrier Gene silencing POLYLYSINE Tumor treatment VEGF siRNA. 
Identification of Klebsiella pneumoniae strains harboring inactive extended-spectrum beta-lactamase antibiotic-resistance genes被引量：4
《Chinese Medical Journal》2014年第17期3051-3057,共7页Xu Li Zhai Yao Lyu Yuan Wang Qi An Shuchang Chen Jichao Chen Yusheng Liu Lin Li Jiabin Gao Zhancheng 
Background The extended-spectrum beta-lactamase （ESBL）-producing Klebsiella pneumoniae has increasingly become a major contributor to nosocomial infections and can exhibit multiple antibiotic resistance.Previous stu...
关键词：Klebsiella pneumoniae extended-spectrum beta-lactamase gene silencing beta-lactam resistance promoter regions 
Polycomb Group Genes as the Key Regulators in Gene Silencing被引量：2
《Wuhan University Journal of Natural Sciences》2014年第1期1-7,共7页SU Shuaikun ZHANG Min LI Lianyun WU Min 
Supported by the National Key Basic Research Program of China(973 Program)(2011CB504206,2012CB518700);the National Natural Science Foundation of China(91019013,31221061,31200653 and 31370866);Program for New Century Excellent Talents in University(NCET-11-0410)
The Polycomb group （PcG） genes repress gene expression mainly through chromatin modifications and regulation of chromatin structure. At present, at/east four protein complexes of PcG proteins are identified, includi...
关键词：POLYCOMB EPIGENETICS histone modifications Polycomb repressive complex transcription regulation 
Non-coding RNAs mediate the rearrangements of genomic DNA in ciliates被引量：2
《Science China(Life Sciences)》2013年第10期937-943,共7页FENG XueZhu GUANG ShouHong 
supported by grants from the National Basic Research Program of China(2011CBA01103);the National Natural Science Foundation of China(31171254);the Fundamental Research Funds for Central Universities(WK2060190018)
Most eukaryotes employ a variety of mechanisms to defend the integrity of their genome by recognizing and silencing parasitic mobile nucleic acids.However,recent studies have shown that genomic DNA undergoes extensive...
关键词：RNAi gene silencing scnRNA PIRNA rearrangement elimination 
Small RNA Interference-mediated Gene Silencing of TREK-1 Potassium Channel in Cultured Astrocytes
《Journal of Huazhong University of Science and Technology(Medical Sciences)》2012年第6期849-855,共7页吴潇 唐荣华 刘阳 宋景娇 喻志源 王伟 谢敏杰 
supported by grants from the National Natural Science Foundation of China (No.30971007);the Natural Science Foundation of Hubei Province for Outstanding Young Scholars (No.2010CDA103);the National Basic Research Program(No.2011CB504403)
This study was aimed to examine the effect of TREK-1 silencing on the function of astrocytes. Three 21-nucleotide small interfering RNA (siRNA) duplexes (siT1, siT2, siT3) targeting TREK-1 were constructed. Cy3-labele...
关键词：TREK-1 ASTROCYTES small interfering RNA ISCHEMIA 
Development and application of an efficient virus-induced gene silencing system in Nicotiana tabacum using geminivirus alphasatellite被引量：11
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2011年第2期83-92,共10页Chang-jun HUANG Tong ZHANG Fang-fang LI Xin-yue ZHANG Xue-ping ZHOU 
supported by the National Science and Technology Major Projects of China (No. 2009ZX08009-026B);the China Postdoctoral Science Foundation (No. 20090461375);the National Basic Research Program (973) of China (No. 2006CB101903)
Virus-induced gene silencing (VIGS) is a recently developed technique for characterizing the function of plant genes by gene transcript suppression and is increasingly used to generate transient loss-of-function assay...
关键词：Virus induced gene silencing GEMINIVIRUS Alphasatellite Nicotiana tabacum 
Epigenetic Repression of SATB1 by Polycomb Group Protein EZH2 in Epithelial Cells被引量：1
《Chinese Medical Sciences Journal》2010年第4期199-205,共7页Chih-chuan Liang 
Supported by National Natural Science Foundation of China (30721063);National Basic Research Program of China (973 Program) (2005CB522402, 2006CB910403);National Laboratory of Medical Molecular Biology grant (2060204);Beijing municipal government grant (YB20081002301)
Objective To study the regulatory mechanism of SATB1 repression in cells other than T cells or erythroid cells, which have high expression level of SATB1. Methods HeLa epithelial cells were treated with either histone...
关键词：SATB 1 EZH2 Polycomb group protein gene silencing trimethylated H3K27 
Impact of STAT4 gene silencing on the expression profile of proteins in EL-4 cells被引量：4
《Chinese Science Bulletin》2009年第18期3265-3270,共6页WEI XiaoLi NI Hong WANG QingShan XIANG Rong WANG Yue 
Supported by the National Key Basic Research and Development Program of China (Grant No. 2007CB914804);National High Technology Research and Development Program of China (Grant No. 2007AA021010);Foundation of the Ministry of Education of China for Returned Scholars;Key Project of the Science & Technology Pillar Program of Tianjin (Grant No. 07ZCKFSH03700);Innovative Research Foundation of Nankai University
The signal transducers and activators of transcription (STATs) have diverse biological functions and are involved in cell differentiation, proliferation, development, apoptosis and inflammation. Several constitutively...
关键词：细胞分化 细胞蛋白 表达谱 基因沉默 转录激活因子 转化生长因子 肿瘤细胞 发光 
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