GLUCOCORTICOIDS

作品数：190被引量：656H指数：12
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Effects of glucocorticoid use on survival of advanced non-small-cell lung cancer patients treated with immune checkpoint inhibitors被引量：1
《Chinese Medical Journal》2023年第21期2562-2572,共11页Nijiao Li Xuliang Zheng Jinyan Gan Ting Zhuo Xiaohong Li Chuyi Yang Yanbin Wu Shouming Qin 
supported by grants from the Guangxi Medical and Health Appropriate Technology Development and Promotion Application Project(No.S201659);the Self-financing Research Projects of Guangxi Zhuang Autonomous Region Health and Family Planning Commission(No.Z20180970).
Background:Lung cancer is the second most common cancer worldwide,with non-small-cell lung cancer(NSCLC)accounting for the majority of cases.Patients with NSCLC have achieved great survival benefits from immunotherapi...
关键词：GLUCOCORTICOIDS Immune checkpoint inhibitor Meta-analysis Non-small-cell lung cancer Prognosis 
Effectiveness of glucocorticoid therapy in patients with severe coronavirus disease 2019:protocol of a randomized controlled trial被引量：10
《Chinese Medical Journal》2020年第9期1080-1086,共7页Yuan-Yuan Qin Yi-Hong Zhou Yan-Qiu Lu Feng Sun Sen Yang Vijay Harypursat Yao-Kai Chen 
This work was supported by the Chongqing Special Research Project for Prevention and Control of Novel Coronavirus Pneumonia(No.cstc2020jscx-fyzx0074)。
Background:At the end of 2019,a novel coronavirus outbreak causative organism has been subsequently designated the 2019 novel coronavirus(2019-nCoV).The effectiveness of adjunctive glucocorticoid therapy in the manage...
关键词：2019 Novel coronavirus Coronavirus disease 2019 GLUCOCORTICOIDS Severe pneumonia Acute respiratory distress syndrome 
Effects of rhubarb on the expression of glucocorticoids receptor and regulation of cellular immunity in burn-induced septic rats被引量：7
《Chinese Medical Journal》2019年第10期1188-1193,共6页Jiao Liu Guang Li Yi-Zhu Chen Li-Di Zhang Tao Wang Zhen-Liang Wen Lu Wang De-Chang Chen 
a grant from the National Natural Science Foundation of China (No. 81571943 and No. 81873944).
Background: It is important to modulate the expression of glucocorticoids receptor (GR) in tress and maintain the immunity homeostasis in sepsis process. Rhubarb have been shown to have potential effects on anti-infla...
关键词：RHUBARB SEPSIS Cellular IMMUNITY GLUCOCORTICOIDS RECEPTOR 
Effects of Glucocorticoid?Induced Transcript 1 Gene Deficiency on Glucocorticoid Activation in Asthmatic Mice被引量：5
《Chinese Medical Journal》2018年第23期2817-2826,共10页Cheng-Ping Hu Qiu-Fen Xun Xiao-Zhao Li Xin-Yue Hu Ling Qin Ruo-Xi He Jun-Tao Feng 
grants from the National Natural Science Foundation of China (No.81270080and No.81670027).
Background: Glucocorticoid (GC) is the first?line therapy for asthma, but some asthmatics are insensitive to it. Glucocorticoid?induced transcript 1 gene (GLCCI1) is reported to be associated with GCs efficiency in as...
关键词：Asthma GLUCOCORTICOID Receptor Glucocorticoid-Induced TRANSCRIPT 1 GLUCOCORTICOIDS MITOGEN-ACTIVATED Protein Kinase Phosphatase-1 
A Historical Cohort Study on the Efficacy of Glucocorticoids and Riboflavin Among Patients with Late-onset Multiple AcyI-CoA Dehydrogenase Deficiency被引量：10
《Chinese Medical Journal》2016年第2期142-146,共5页Xin-Yi Liu Zhi-Qiang Wang Dan-Ni Wang Min-Ting Lin Ning Wang 
grants from the National Natural Science Foundation of China，National Key Clinical Specialty Discipline Construction Program,and Fujian Key Clinical Specialty Discipline Construction Program
Background： Late-onset multiple acyl-CoA dehydrogenase deficiency （MADD） is the most common type of lipid storage myopathies in China. Most patients with late-onset MADD are well responsive to riboflavin. Up to now...
关键词：GLUCOCORTICOIDS Historical Cohort Study Late-onset Multiple Acyl-CoA Dehydrogenase Deficiency Lipid StorageMyopathy RIBOFLAVIN 
Glucocorticoids Significantly Influence the Transcriptome of Bone Microvascular Endothelial Cells of Human Femoral Head被引量：9
《Chinese Medical Journal》2015年第14期1956-1963,共8页Qing-Sheng Yu Wan-Shou Guo Li-Ming Cheng Yu-Feng Lu Jian-Ying Shen Ping Li 
Source of Support： This work was funded by a grant from National Natural Science Foundation of China （No. 81273972）. Conflict of Interest： None declared.
Background： Appropriate expression and regulation of the transcriptome, which mainly comprise ofmRNAs and lncRNAs, are important for all biological and cellular processes including the physiological activities of bon...
关键词：Co-expression Network Intracellular Signaling Pathway Microvascular Endothelial Ceils Noncoding RNAs OSTEONECROSIS 
Clinical Research on Benign Lymphoepithelial Lesions of Lacrimal Gland in 20 Chinese Patients被引量：10
《Chinese Medical Journal》2015年第4期493-498,共6页Jian-Min Ma Jing Li Xin Ge Ming Li Jin-Ru Li Xiao-Na Wang 
This study was supported by two grants from National Natural Science Foundation of China
Background：Benign lymphoepithelial lesion （BLEL） is characterized by symmetric bilateral swelling of the lacrimal and salivary glands and considered a subtype of immunoglobulin G4 （IgG4）-related sclerosing diseas...
关键词：Benign Lymphoepithelial Lesion GLUCOCORTICOIDS Immunoglobulin G4 Lacrimal Gland SURGERY 
Gastrodin prevents steroid-induced osteonecrosis of the femoral head in rats by anti-apoptosis被引量：18
《Chinese Medical Journal》2014年第22期3926-3931,共6页Zheng Huifeng Yang Erping Peng Hao Li Jianping Chen Sen Zhou Jianlin Fang Hongsong Qiu Bo Wang Zhe 
This work was supported by a grant from the National Natural Science Foundation of China （No. 81301592）.
Background Gastrodin,as one of the major components extracted from the Chinese herb Gastrodia elata BI.,has many biologic effects,one of which is anti-apoptosis.Apoptosis is considered to be one of the pathogenetic me...
关键词：GLUCOCORTICOIDS GASTRODIN femoral head osteonecrosis PREVENTION APOPTOSIS 
Effects of glucocorticoids on traumatic brain injury related critical illness-related corticosteroid insufficiency被引量：10
《Chinese Medical Journal》2013年第19期3754-3761,共8页ZHAO Zi-long CHEN Xin ZHU Hui ZHANG Bao-liang CHAI Yan LI Xin-yuan DONG Jing-fei ZHANG Jian-ning 
This work was supported by grants from the National Natural Science Foundation of China （No. 81000533）, the Project of Tianjin Applied Basic and Cutting-edge Technological Research （No. 13JCQNJC10500） and National Key Basic Research Program in China （No. 2005CB522600）. Conflicts of interest： none.
Background Traumatic brain injury （TBI） is a heterogeneous condition that can lead to critical LLLness-related corticosteroid insufficiency （CIRCI） causing a high mortality and morbidity.Glucocorticoids were widel...
关键词：traumatic brain injury critical illness related corticosteroid insufficiency  mere-analysis stress-dose glucocorticoid 
Neuropsychiatric disorders and cognitive dysfunction in patients with Cushing＇s disease被引量：6
《Chinese Medical Journal》2013年第16期3156-3160,共5页CHEN Yu-fan LI Yun-feng CHEN Xiao SUN Qing-fang 
This work was supported by a grant of the National Natural Science Foundation of China （No. 81270856）. Conflict of interest： none.
Objective To review the main neuropsychiatric disorders and cognitive deficits in patients with Cushing＇s disease （CD） and the associated pathophysiological mechanisms underlying CD.These mechanistic details may pr...
关键词：cushing＇s disease PSYCHOLOGY cognitive symptoms HIPPOCAMPAL GLUCOCORTICOIDS 
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