HARRINGTONINE

作品数：9被引量：13H指数：2
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相关期刊：《Science Bulletin》《癌变．畸变．突变》《Science China(Life Sciences)》《Journal of Pharmaceutical Analysis》更多>>
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Two-Dimensional （Polyacrylamide） Gel Electrophoresis Analysis of Apoptosis Induced by Harringtonine in K562 Cells
《Chinese Journal of Clinical Oncology》2005年第3期647-653,共7页RongLi XiaoliLiu QingfengDu SongZhong ShuyunZhou 
OBJECTIVE The anti-tumor drug, harringtonine (HT), has been extensively used with satisfactory results in the treatment of acute or chronic myeloid leukemia. Previous studies have shown that the anti-tumor activity of...
关键词：聚丙烯酰胺 二维空间 凝胶电泳 三尖杉酯碱 K562 细胞凋亡 抗肿瘤药 
EFFECTS OF THE HYPERTHERMIA AND HARRINGTONINE ON TELOMERASE ACTIVITY OF HL-60 CELLS
《Journal of Pharmaceutical Analysis》2002年第1期78-80,共3页王宝燕 张海涛 李静 
ThisresearchwassupportedbytheScienceFoundationoftheFirstHospitalofXi’anJiaotongUniversity
Objective To understand the mechanism of the hyperthermia and harringtonine in purging of leukemia cells In Vitro. telomerase activity of HL-60 cells treated by hyperthermia ( 42℃ for one hour) and different concen...
关键词：TELOMERASE HL-60 cells HYPERTHERMIA HARRINGTONINE 
Simultaneous multi-parameter observation of Harring-tonine-treating HL-60 cells with both two-photon and confocal laser scanning microscopy被引量：7
《Science China(Life Sciences)》2001年第4期383-391,共9页张春阳 李艳平 马辉 李素文 薛绍白 陈瓞延 
the Tsinghua University Foundation for Basic Research and the Chinese Postdoctoral Foundation.
Harringtonine (HT), a kind of anticancer drug isolated from Chinese herb-Cephalotaxus hainanensis Li, can induce apoptosis in promyelocytic leukemia HL-60 cells. With both two-photon laser scanning microscopy and conf...
关键词：TWO-PHOTON LASER SCANNING microscopy  confocal LASER SCANNING microscopy  Harringtonine  HL-60 cells. 
Role of calcium in apoptosis of HL-60 cells induced by harringtonine被引量：4
《Science China(Life Sciences)》1998年第6期600-607,共8页方敏 张鸿卿 薛绍白 
theNationalNaturalScienceFoundationofChina (GrantNos.39730 16 0and 396 70 2 0 4 );theNa tionalEducationalCommissionDoctor’sFoundationofChina
The effect of Ca 2+ on HT induced apoptosis in HL 60 cells was examined. Characteristics of apoptosis induced by harringtonine (HT) or campothecin (CAM) could not be abolished by extracellular calcium chelator EGTA; h...
关键词：APOPTOSIS HARRINGTONINE campothecin CALCIUM ion VIDEO enhancement CONTRAST microscopy. 
Induction of apoptosis in HL-60 cells by harringtonine被引量：2
《Chinese Science Bulletin》1995年第11期939-944,共6页方敏 张鸿卿 薛绍白 庞大本 池旭生 
Project supported by the National Natural Science Foundation of China and the Foundation for Doctors Cultivation from States Education Committee of China.
Recently, many reports showed that most of cytotoxic anticancer drugs in current usesuch as DNA topoisomerase Ⅰinhibitor camptothecin (CAM), or DNA topoisomerase Ⅱinhibitor teniposide (TEN) could induee apoptosis in...
关键词：APOPTOSIS HL-60 CELL harringtonine. 
Increase of Glutathione in Harringtonine-Resistant HL-60 Cells
《Chinese Science Bulletin》1993年第23期2009-2014,共6页何农高 王瑞虹 张鸿卿 薛绍白 
The work was supported by the National Natural Science Foundation of China ; the Foundation for Doctors Cultivation from State Education Committee of China.
Glutathione (GSH) is an intracellular tripeptide thiol which is involved in many physiological activities such as detoxification of electrophiles and peroxide regulation of enzyme activity, transportation of amino aci...
关键词：GLUTATHIONE cell cycle HL-60 cells MULTIDRUG resistance HARRINGTONINE microfluorophotometry. 
INDUCED OF CYTOTOXICOLOGY AND MORPHOLOGICAL TRANSFORMATION IN C3H 1OT1/2 CLONE 8 MOUSE EMBRYO CELL LINE BY FLUBENDAZOLE AND HARRINGTONINE
《癌变．畸变．突变》1991年第S1期68-68,共1页liliana Cerepralkoski Michcel Dews Joseph R.Landolph 
The antiparacitic agent Flubendazole (F) caused a dose-dependent and time-dependent induction of polyploid in C3H1OT cells.At concentrations of 78ug/ml the yield of polyploidcells was 95％.Harringtonine(H),a antineopl...
关键词：CHROMOSOME CELL morphological induction TRAIL FACTS 
DETERMINATION OF SERUM HARRINGTONINE IN PATIENTS WITH ANLL AND ITS CLINICAL IMPLICATION
《Chinese Journal of Cancer Research》1990年第3期65-70,共6页李晓 卢家祥 周康 陈秋潮 陈新 张国祯 
Harringtonine(H) level in serum was quantified by high-performance liquid chromatographic (HPLC) technique and its pharmacokinetic parameters were determined in 11 patients with ANLL after 4 hours continuous infusion ...
关键词：ANLL DETERMINATION OF SERUM HARRINGTONINE IN PATIENTS WITH ANLL AND ITS CLINICAL IMPLICATION 
SYNTHESIS OF SIMILARS OF ISO HARRINGTONINE
《Chinese Science Bulletin》1987年第8期532-535,共4页李裕林 李绍白 崔育新 李宇 黄飞跃 陈国华 
Project supported by the Science Fund of Academia Sinica
Isoharringtonine (1), which has been originally isolated from the plants of genus Cephalotaxus, is one of the four ester alkaloids exhibiting antitumor activity. It has been successfully synthesized in three different...
关键词：originally ALKALOIDS ANTITUMOR carefully erythro ESTERS 映芝 今回 INHIBIT NECESSITY 
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