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IMMUNO: 作品数：466被引量：1235H指数：18; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：杨安钢倪皓邵宗鸿任悦付蓉更多>>; 相关机构：第四军医大学空军军医大学（第四军医大学）北京大学三峡大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家高技术研究发展计划国家教育部博士点基金国家重点基础研究发展计划更多>>

Unlocking the potential of immunotherapy in platinum-resistant ovarian cancer:rationale,challenges,and novel strategies: 《Cancer Drug Resistance》2024年第1期309-331,共23页Joanna Kefas Michael Flynn; Ovarian cancer is a significant global health challenge,with cytoreductive surgery and platinum-based chemotherapy serving as established primary treatments.Unfortunately,most patients relapse and ultimately become pl...; 关键词：Ovarian cancer IMMUNOTHERAPY immune checkpoint inhibition immunotherapy resistance

Mechanisms of immunotherapy resistance in small cell lung cancer: 《Cancer Drug Resistance》2024年第1期1-23,共23页Yunan Nie Kurt A.Schalper Anne Chiang; Small-cell lung cancer(SCLC)is an aggressive neuroendocrine tumor with a poor prognosis.Although the addition of immunotherapy to chemotherapy has modestly improved outcomes,most patients rapidly develop resistance.Re...; 关键词：Immunotherapy resistance small cell lung cancer BIOMARKER primary resistance acquired resistance

Current knowledge about immunotherapy resistance for melanoma and potential predictive and prognostic biomarkers: 《Cancer Drug Resistance》2024年第1期748-771,共24页Lanni Song Yixin Yang Xuechen Tian; funded by Wenzhou Municipal Key Laboratory for Applied Biomedical and the Biopharmaceutical Informatics[WB20211227000125];Zhejiang Bioinformatics International Science and Technology Cooperation Center at Wenzhou-Kean University[WB20210429000008].; Melanoma still reaches thousands of new diagnoses per year,and its aggressiveness makes recovery challenging,especially for those with stage III/IV unresectable melanoma.Immunotherapy,emerging as a beacon of hope,stan...; 关键词：MELANOMA IMMUNOTHERAPY resistance mechanism tumor microenvironment biomarkers

Tumor-intrinsic metabolic reprogramming and how it drives resistance to anti-PD-1/PD-L1 treatment被引量：1: 《Cancer Drug Resistance》2023年第3期611-641,共31页Kyra Laubach Tolga Turan Rebecca Mathew Julie Wilsbacher John Engelhardt Josue Samayoa; This article was funded by AbbVie,Inc.; The development of immune checkpoint blockade (ICB) therapies has been instrumental in advancing the field of immunotherapy. Despite the prominence of these treatments, many patients exhibit primary or acquired resist...; 关键词：Immunotherapy resistance tumor-immune microenvironment immune checkpoint blockade energy metabolism amino acid metabolism lipid metabolism

Cancer resistance to immunotherapy: What is the role of cancer stem cells?: 《Cancer Drug Resistance》2022年第4期981-994,共14页Gourab Gupta George Merhej Shakthika Saravanan Hexin Chen; Immunotherapy is an emerging form of cancer therapy that is associated with promising outcomes.However,most cancer patients either do not respond to immunotherapy or develop resistance to treatment.The resistance to i...; 关键词：IMMUNOTHERAPY cancer stem cells immunotherapy resistance tumor microenvironment

Circular RNA drives resistance to anti-PD-1 immunotherapy by regulating the miR-30a-5p/SOX4 axis in non-small cell lung cancer被引量：2: 《Cancer Drug Resistance》2022年第2期261-270,共10页Jing Wu Meng-Xuan Zhu Ke-Sang Li Ling Peng Peng-Fei Zhang; This study was funded by the National Natural Science Foundation of China(82072575);Medical Scientific Research Foundation of Zhejiang Province,China(2019KY176).; Aim:Circular RNAs are widely and abnormally expressed in human cancer cells,and they participate in cancer progression.However,they have rarely been investigated in the immune evasion of non-small cell lung cancer(NSC...; 关键词：NSCLC immune evasion circRNAs PD-1 immunotherapy resistance

Immunotherapy resistance of lung cancer被引量：3: 《Cancer Drug Resistance》2022年第1期114-128,共15页Xin Yu Chaonan Han Chunxia Su; supported by National Natural Science Foundation of China(grant number:81874036,82072568);Science and Technology Commission of Shanghai Municipality(19411971100);Shanghai Shenkang Hospital Development Center(SHDC12020110).; In recent years,immunotherapy has made remarkable breakthroughs and brought long-term survival benefits to lung cancer patients.However,a high percentage of patients do not respond to immunotherapy or their responses ...; 关键词：IMMUNOTHERAPY resistance mechanisms response strategies

Emerging mechanisms of immunotherapy resistance in sarcomas: 《Cancer Drug Resistance》2022年第1期199-213,共15页Vaia Florou Breelyn A.Wilky; Sarcomas are a heterogeneous group of over 150 mesenchymal neoplasms of bone and soft tissue.Clinical prognosis remains poor in the metastatic and refractory setting,despite treatment with traditional chemotherapies.A...; 关键词：SARCOMA immune therapy immune resistance IMMUNOGENICITY CHEMOTHERAPY clinical trials

The tumor microenvironment of pancreatic adenocarcinoma and immune checkpoint inhibitor resistance: a perplex relationship: 《Cancer Drug Resistance》2020年第4期699-709,共11页Irem Sahin Sevda Turen Pranav Santapuram Ibrahim Halil Sahin; Pancreatic cancer is one of the most aggressive cancers with a high mortality rate even among patients with early-stage disease.Although recent studies with novel therapeutic approaches have led to modest improvement ...; 关键词：Pancreatic adenocarcinoma durvalumab nivolumab IPILIMUMAB pembrolizumab immune checkpoint inhibitors immunotherapy resistance mismatch repair deficient microsatellite instability high microsatellite stable tumor-associated macrophages myeloid-derived suppressor cells T regs T cells

A review of mechanisms of resistance to immune checkpoint inhibitors and potential strategies for therapy: 《Cancer Drug Resistance》2020年第3期252-275,共24页Yu Fujiwara Arjun Mittra Abdul Rafeh Naqash Naoko Takebe; Immune checkpoint inhibitors(ICIs)have revolutionized the treatment of cancer over the last decade,bringing about a paradigm shift in systemic cancer therapy away from traditional cytotoxic and targeted therapies.Whil...; 关键词：Immunotherapy resistance tumor microenvironment PD-1 PD-L1 CTLA-4

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