Supported by the National Key Technology Support Program during “12th Five-Year Plan”period of China,No.2014BAI08B00;the Leapforward Development Program for Beijing Biopharmaceutical Industry(G20),No. Z171100001717008.
BACKGROUND Visceral hypersensitivity and psychological performance are the main pathophysiological mechanisms of irritable bowel syndrome(IBS).Previous studies have found that cholecystokinin(CCK)can enhance colon mov...
Research supported by New Zealand College of Chinese Medicine
Irritable bowel syndrome(IBS)is a relatively common condition characterized by abdominal pain,among other symptoms,that significantly impacts the quality of life of IBS patients.Therapeutic treatment of IBS results in...
the National Key Technology Support Program for the “12th Five-Year Plan” of China,No.2014BAI08B00;the Research Projects on Biomedical Transformation of China-Japan Friendship Hospital,No.PYBZ1815
BACKGROUND Fecal metabolites are associated with gut visceral sensitivity,mucosal immune function and intestinal barrier function,all of which have critical roles in the pathogenesis of irritable bowel syndrome(IBS).H...
grants from the National Natural Science Foundation of China(No.81670491);National“Twelfth Five-Year”Plan for Science and Technology of China(No.2012BAI06B02).
Background:Irritable bowel syndrome (IBS),a functional gastrointestinal disorder,is characterized by cytokine imbalance.Previously,decreased plasma interleukin 10 (IL-10) level was reported in patients with IBS,which ...
supported by grants from the National Natural Science Foundation of China(81471137,31730040,and 81500952);the Priority Academic Program Development of Jiangsu Higher Education Institutions of China
The pathophysiology of visceral pain in patients with irritable bowel syndrome remains largely unknown.Our previous study showed that neonatal maternal deprivation(NMD) does not induce visceral hypersensitivity at the...
Supported by the National Key Technology Support Program during "12th Five-Year Plan"Period of China,No.2014BAI08B00;the Leapforward Development Program for Beijing Biopharmaceutical Industry(G20),No.Z171100001717008
BACKGROUND Visceral hypersensitivity is considered to play a vital role in the pathogenesis of irritable bowel syndrome(IBS). Neurotrophins have drawn much attention in IBS recently. Brain-derived neurotrophic factor(...
Supported by National key Technology Support Program during the"12th Five-Year Plan"Period of China,No.2014BAI08B02
AIM To measure the leptin levels in patients with diarrheapredominant irritable bowel syndrome(IBS-D) and analyze the relationship of leptin with clinical features, visceral sensitivity, mast cells, and nerve fibers. ...
AIM To determine the effects of Lactobacillus acidophilus NCFM on irritable bowel syndrome(IBS) symptoms and quality of life(Qo L).METHODS In this randomized triple-blind trial, adult IBS volunteerswho were recruited ...
Supported by National Natural Science Foundation of China,No.81330012 and No.81170352
AIM: To evaluate gut microbial dysbiosis in two visceral hypersensitive models in comparison with irritable bowel syndrome(IBS) patients and to explore the extent to which these models capture the dysbiosis of IBS pat...
supported by Natural Science Foundation of China Grant(No.81160057):International Science and Technique Corporation Foundation of Hainan Province Grant(No.KJHZ2013-14)
Objective:To investigate the impact of the preinduced intestinal heat shock protein 70(HSP70)on the visceral hypersensitivity and abnormal intestinal motility in a post-infectious irritable bowel syndrome(PI-IBS) mous...