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作品数：254被引量：586H指数：10
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Gut microbiota modulates oligodendrocyte lineage cell response after traumatic brain injury
《Neural Regeneration Research》2026年第1期310-311,共2页Kirill Shumilov Stuart Friess 
Traumatic brain injury(TBI)is a significant public health issue,affecting approximately 1.7 million people annually in the United States alone,with over 5 million experiencing long-term disabilities(Roozenbeek et al.,...
关键词：TRAUMATIC INJURY 
Oligodendroglial heterogeneity in health,disease,and recovery:deeper insights into myelin dynamics
《Neural Regeneration Research》2025年第11期3179-3192,共14页Pieter-Jan Serneels Julie D.De Schutter Lies De Groef Lieve Moons Steven Bergmans 
supported by KU Leuven Internal Funding(C3/21/012);the Research Foundation Flanders(FWO G092222N)(to LM)。
Decades of research asserted that the oligodendroglial lineage comprises two cell types:oligodendrocyte precursor cells and oligodendrocytes.However,recent studies employing single-cell RNA sequencing techniques have ...
关键词：animal models DEMYELINATION fish MAMMALS multiple sclerosis MYELIN neurodegeneration OLIGODENDROCYTES oligodendroglial lineage REMYELINATION 
Treatment of immunoglobulin A nephropathy:Current perspective and future prospects
《World Journal of Clinical Cases》2025年第19期5-10,共6页Yusuf ZiyaŞener SeherŞener 
Immunoglobulin(Ig)A nephropathy is the most common type of primary glomerulonephritis globally.It typically manifests with microscopic hematuria and a spectrum of proteinuria,although rapidly progressive glomeruloneph...
关键词：Immunoglobulin A nephropathy Telitacicept Complement inhibitors B-cell lineage depletion Anti-proteinuric treatment 
AUTS2 expression within mammalian lineage: A predictor of neural networks involved in autism spectrum disorders
《Genes & Diseases》2025年第3期11-14,共4页Aude-Marie Lepagnol-Bestel Yann Loe-Mie Mounia Bensaid Michel Simonneau 
founded by SFR Cap Santé,Universitéde Reims Champagne-Ardenne,Reims,France to Aude-Marie Lepagnol-Bestel,a European Grant ERA-Net Cofund Action on Nanomedicine under Horizon 2020 Euronanomed 3(project MoDiaNo);CNES(Centre National d'Etudes Spatiales)grant(MemoBion)to Michel Simonneau.
The autism susceptibility candidate 2(AUTS2)gene1,2 at 7q11.2 was first identified and found disrupted because of a balanced translocation in a pair of monozygotic twins with autism spectrum disorder(ASD).Analysis of ...
关键词：balanced translocation auts novel cases autism spectrum disorders autism spectrum disorder asd analysis clinical phenotypes monozygotic twins intellectual disability 
A novel research model of clonal evolution in mantle cell lymphoma at the single-cell genomic level
《Genes & Diseases》2025年第3期35-38,共4页Li Zhang Yongsheng Liu Liang Wang Li Wang Li Zheng Wei He Li Yan Lvsu Ye Huidan Zhang Junling Tang 
funded by the Chongqing Medical Scientific Research Project(Joint Project of Chongqing Health Commission and Science and Technology Bureau,China)(No.2023GGXM006,2024ZDXM026,2024MSXM115);the Key Research Project from Science and Technology Department of Sichuan Province,China(No.2019YFS0301);the Chongqing Key Municipal Public Health Specialty Construction Project(China);the Key Research Project from Chongqing Medical and Pharmaceutical Vocational Education Group(China)(No.CQZJ202329);the Incubation Project of the First Affiliated Hospital of Chongqing Medical and Pharmaceutical College(China)(No.2022-2023ZD04,2022-2023ZD03,2022-2023MS04,2022-2023MS03,2022-2023MS010);the Science and Technology Research Program of Chongqing Education Commission(China)(No.KJQN202302811).
Mantle cell lymphoma(MCL)is recognized as one of the most genetically heterogeneous diseases,with high instability at the genomic level.MCL is common in males with a male-to-female ratio of about 2:1,and its incidence...
关键词：hematopoietic lineage mantle cell lymphoma mcl clonal evolution genomic instability tumor immunity evolution tree single cell genomic level genetic heterogeneity mantle cell lymphoma 
Transient chemical-mediated epigenetic modulation confers unrestricted lineage potential on human primed pluripotent stem cells
《Science China(Life Sciences)》2025年第4期1084-1101,共18页Shi Chen Yuanyuan He Lejun Lv Bei Liu Cheng Li Hongkui Deng Jun Xu 
supported by the National Key Research and Development Program of China(2021YFA1100300);the National Natural Science Foundation of China(32288102,32370843 and 32025006)Part of the data analysis was performed on the High Performance Computing Platform of the Center for Life Sciences,Peking University。
Human primed pluripotent stem cells are capable of generating all the embryonic lineages.However,their extraembryonic trophectoderm potentials are limited.It remains unclear how to expand their developmental potential...
关键词：trophectoderm lineages human primed pluripotent stem cells epigenetic regulation small molecules 
Autophagy in Oligodendrocyte Lineage Cells Controls Oligodendrocyte Numbers and Myelin Integrity in an Age‑dependent Manner
《Neuroscience Bulletin》2025年第3期374-390,共17页Hong Chen Gang Yang De‑En Xu Yu‑tong Du Chao Zhu Hua Hu Li Luo Lei Feng Wenhui Huang Yan‑Yun Sun Quan‑Hong Ma 
supported by the STI2030-Major Projects(2021ZD0204001);the National Natural Science Foundation of China(92049120,81870897,81271424,81671111,and 62475179);the Sino German Cooperation and Exchange Project(M-0679);the Guangdong Key Project in the Development of New Tools for the Diagnosis and Treatment of Autism(2018B030335001);the Natural Science Foundation of Jiangsu Province(BK20181436);the Priority Academic Program Development of Jiangsu Higher Education Institutions,the Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases(BM2013003);Suzhou International Joint Laboratory for Diagnosis and Treatment of Brain Diseases,Suzhou Science and Technology Plan Medical and Health Care Science and Technology Innovation Applied Basic Research(SKY2022161);the Research Project of Neurological Diseases in the Second Affiliated Hospital of Soochow University Research Center(ND2023A01);Boxi clinical research project of The First Affiliated Hospital of Soochow University(BXQN202204);Suzhou Science&Technology Projects for People's Livelihood(SKY2021065);Wuxi Municipal Health Commission(M202204).
Oligodendrocyte lineage cells, including oligodendrocyte precursor cells (OPCs) and oligodendrocytes (OLs), are essential in establishing and maintaining brain circuits. Autophagy is a conserved process that keeps the...
关键词：AUTOPHAGY Oligodendrocyte precursor cells OLIGODENDROCYTES MYELINATION Myelin proteins Turnover Degradation 
Correction to:Autophagy in Oligodendrocyte Lineage Cells Controls Oligodendrocyte Numbers and Myelin Integrity in an Age‑dependent Manner
《Neuroscience Bulletin》2025年第3期547-548,共2页
Integrated analysis of single-cell and bulk transcriptomes uncovers clinically relevant molecular subtypes in human prostate cancer
《Chinese Journal of Cancer Research》2025年第1期90-114,共25页Tao Ding Lina He Guowen Lin Lei Xu Yanjun Zhu Xinan Wang Xuefei Liu Jianming Guo Fanghong Lei Zhixiang Zuo Jianghua Zheng 
supported by Shanghai Science and Technology Commission,China(No.21S11902100);Shanghai Municipal Health Commission Scientific Research Project(No.202140308);Clinical Research Project of Tongji Hospital of Tongji University[No.ITJ(ZD)2209];Shanghai Tongji Hospital National Natural Science Foundation Cultivation Project(No.GJPY2216);Shanghai Medical Innovation Research Special Foundation(No.23Y11908800);CSCO-Haosen Oncology Research Fund(No.Y-HS202301-0096).
Objective:Prostate cancer(PCa)is a complex disease characterized by diverse cellular ecosystems within the tumor microenvironment(TME)and high tumor heterogeneity,which challenges clinically stratified management and ...
关键词：Single-cell RNA sequencing prostate cancer lineage plasticity tumor heterogeneity molecular classification 
Driving effect of P16 methylation on telomerase reverse transcriptase-mediated immortalization and transformation of normal human fibroblasts
《Chinese Medical Journal》2025年第3期332-342,共11页Xuehong Zhang Paiyun Li Ying Gan Shengyan Xiang Liankun Gu Jing Zhou Xiaorui Zhou Peihuang Wu Baozhen Zhang Dajun Deng 
National Natural Science Foundation of China(Nos.81773036,82073102,82073107,and 31261140372);Beijing Municipal Natural Science Foundation(No.7222022)
Background:P16 inactivation is frequently accompanied by telomerase reverse transcriptase(TERT)amplification in human cancer genomes.P16 inactivation by DNA methylation often occurs automatically during immortalizatio...
关键词：P16 methylation Telomerase reverse transcriptase IMMORTALIZATION Transformation Barcode lineage tracking Human fibroblasts 
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