LIVER_FIBROSIS

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Global trends in artificial intelligence applications in liver disease over seventeen years
《World Journal of Hepatology》2025年第3期192-207,共16页Xue-Qin Zhou Shu Huang Xia-Min Shi Sha Liu Wei Zhang Lei Shi Mu-Han Lv Xiao-Wei Tang 
Supported by Natural Science Foundation of Sichuan Province,China,No.2022NSFSC1378.
BACKGROUND In recent years,the utilization of artificial intelligence(AI)technology has gained prominence in the field of liver disease.AIM To analyzes AI research in the field of liver disease,summarizes the current ...
关键词：Artificial intelligence Liver disease Hepatocellular carcinoma Liver fibrosis Bibliometric analysis 
Modern ultrasound techniques for diagnosing liver steatosis and fibrosis:A systematic review with a focus on biopsy comparison
《World Journal of Hepatology》2025年第2期200-224,共25页Patryk Pozowski Mateusz Bilski Maciej Bedrylo PawełSitny Urszula Zaleska-Dorobisz 
Supported by Wroclaw Medical University’s Grant,No.SUBZ.C270.24.078.
BACKGROUND This review evaluated the diagnostic effectiveness of various ultrasound(US)methods compared to liver biopsy.AIM To determine the diagnostic accuracy of US techniques in assessing liver fibrosis and steatos...
关键词：Ultrasound diagnosis Liver steatosis Liver fibrosis Diagnostic accuracy Liver biopsy 
Fibrotic liver extracellular matrix induces cancerous phenotype in biomimetic micro-tissues of hepatocellular carcinoma model
《Hepatobiliary & Pancreatic Diseases International》2025年第1期92-103,共12页Kosar Nouri Abbas Piryaei Homeyra Seydi Ibrahim Zarkesh Ibrahim Ghoytasi Bahare Shokouhian Mustapha Najimi Massoud Vosough 
financially supported by grants from Royan In-stitute(grant No.400000200);Bahar Tashkhis Teb Co.(BTT,9703,9809,and 9903)。
Background: Despite considerable advancements in identifying factors contributing to the development of hepatocellular carcinoma(HCC), the pathogenesis of HCC remains unclear. In many cases, HCC is a consequence of pr...
关键词：Liver fibrosis Decellularized extracellular matrix SPHEROID Epithelial-to-mesenchymal transition Cell differentiation Hepatocellular carcinoma 
Serum ECM1 is a promising biomarker for staging and monitoring fibrosis in patients with chronic hepatitis B
《Science China(Life Sciences)》2025年第2期431-440,共10页Lian Liu Danyan Zhang Rong Fan Shipeng Cheng Jichao Yang Liyan Ma Zhiyang Ling Yaguang Zhang Jinlin Hou Xiaomei Wang Bing Sun Junqi Niu 
supported by the Shanghai Municipal Science and Technology Major Project(ZD2021CY001);the Shanghai Foundation(20S11901800);Special Project of the National Key research and development Program“Research on Pathogenics and Epidemic Prevention Technology System”(2023YFC2308600);National Natural Science Foundation of China(82361148722)。
It is critical to assess the extent and progression of liver fibrosis for patients to receive suitable treatments,but its diagnostic methods remain unmet.Extracellular matrix protein 1(ECM1)has previously been reporte...
关键词：ECM1 EPA score NONINVASIVE BIOMARKER dynamic liver fibrosis injury 
Hotspots and trends in stem cell therapy for liver fibrosis and cirrhosis: A bibliometric analysis
《World Journal of Hepatology》2025年第1期112-131,共20页Wen-Yan Zhu Xiang Li Jia-Ling Xie Qin Lu Ying-Jie Ma Zhao-Jing Zhu Juan Liu 
Supported by the School-Level Project Fund of Chongqing Medical and Pharmaceutical College,No.Ygzrc2023109;the Science and Technology Research Program of Chongqing Municipal Education Commission,No.KJQN202302822;the Special Fund for Agro-Scientific Research in The Public Interest,No.201303040-05;the Special Project for Fundamental Work of Science and Technology,No.2013FY110600-03.
BACKGROUND Liver fibrosis and cirrhosis are global medical challenges that require safe and effective treatments.In the past two decades,there has been a surge in research on stem cell therapy for liver fibrosis and c...
关键词：Liver fibrosis CIRRHOSIS Stem cell therapy Mesenchymal stromal cell Extracellular vesicles EXOSOMES BIBLIOMETRICS 
Hepatitis B virus infection and metabolic dysfunction associated steatotic liver disease:Rising pandemic with complex interaction
《World Journal of Hepatology》2025年第1期172-175,共4页Ammara A Majeed Amna S Butt 
Due to sedentary lifestyle and rising prevalence of obesity,patients with general population and those who are infected with chronic hepatitis B are found to have metabolic dysfunction associated steatotic liver disea...
关键词：Chronic hepatitis B virus infection Obesity Metabolic syndrome Liver fibrosis Steatotic liver disease 
Elafibranor:A promising therapeutic approach for liver fibrosis and gut barrier dysfunction in alcohol-associated liver disease
《World Journal of Gastroenterology》2025年第3期123-126,共4页Chun-Han Cheng Wen-Rui Hao Tzu-Hurng Cheng 
This article discusses the recent study written by Koizumi et al.Alcohol-associated liver disease(ALD)is a major cause of liver-related morbidity and mortality,which is driven by complex mechanisms,including lipid acc...
关键词：Elafibranor Liver fibrosis Gut barrier function Alcohol-associated liver disease Peroxisome proliferatoractivated receptor agonists 
Luteolin-7-diglucuronide,a novel PTP1B inhibitor,ameliorates hepatic stellate cell activation and liver fibrosis in mice
《Acta Pharmacologica Sinica》2025年第1期122-133,共12页Bi-xi Tang Yong Zhang Dan-dan Sun Qin-yi Liu Cong Li Pei-pei Wang Li-xin Gao Xue-mei Zhang Jia Li Wei-liang Zhu Yi Zang 
This article was supported by Shanghai lnstitute of Materia Medica,Chinese Academy of Sciences(No.CASIMM0120225006-2,SIMM0120232001);Shanghai Municipal Science and Technology Major Project(TM202301H002);Shanghai Committee of Science and Technology(22ZR1415200).
Liver fibrosis,one of the leading causes of morbidity and mortality worldwide,lacks effective therapy.The activation of hepatic stellate cells(HSCs)is the dominant event in hepatic fibrogenesis.Luteolin-7-diglucuronid...
关键词：liver fibrosis PHYTOCHEMICAL luteolin 7-diglucuronide HSC activation PTP1B 
Therapeutic potential of elafibranor in alcohol-associated liver disease: Insights into macrophage modulation and fibrosis reduction
《World Journal of Biological Chemistry》2025年第1期1-9,共9页Samira Farhadi Saeed Mohammadi Abdulaziz Y AlKindi Issa S Al-Amri 
Alcohol-associated liver disease(ALD)is a major global health concern,contributing to liver injury,morbidity,and mortality.Elafibranor(EFN),a dual peroxisome proliferator-activated receptorα/δagonist,has shown promi...
关键词：Alcohol-associated liver disease Elafibranor Peroxisome proliferator-activated receptorα/δagonist MACROPHAGES Liver fibrosis Inflammatory responses 
Red cell distribution width/platelet ratio predicts decompensation of metabolic dysfunction-associated steatotic liver disease-related compensated advanced chronic liver disease
《World Journal of Gastroenterology》2025年第3期1-10,共10页Ming-Hua Zheng Amedeo Lonardo 
Prognostication of compensated advanced chronic liver disease(cACLD)is of paramount importance for the physician-and-patient communication and for rational clinical decisions.The paper published by Dallio et al report...
关键词：Cirrhosis Liver fibrosis Natural course PROGNOSTICATION STRATIFICATION 
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