LIVER_FIBROSIS

作品数：694被引量：3997H指数：26
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相关机构：华中科技大学广州医科大学第三军医大学西南医院南方医科大学更多>>
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Quantification of Streptococcus salivarius using the digital polymerase chain reaction as a liver fibrosis marker
《World Journal of Hepatology》2025年第4期53-66,共14页Shuichiro Iwasaki Akira Také Haruki Uojima Kazue Horio Yoshihiko Sakaguchi Kazuyoshi Gotoh Takashi Satoh Hisashi Hidaka Yasuhito Tanaka Shunji Hayashi Chika Kusano 
Supported by JSPS KAKENHI,No.23K15083.
BACKGROUND The Streptococcus salivarius(S.salivarius)group,which produces the enzyme urease has been identified as a potential contributor to ammonia production in the gut.Researchers have reported that patients with ...
关键词：Chronic liver disease Streptococcus salivarius Digital PCR Liver fibrosis Liver cirrhosis Quantification 
Psoriasis,metabolic syndrome and methotrexate:Is this association suitable for a new subcategory in steatotic liver disease?
《World Journal of Hepatology》2025年第4期11-18,共8页Luciana Agoglia Maria Chiara Chindamo Cristiane Villela-Nogueira 
Psoriasis is a prevalent inflammatory disease that shares chronic inflammation pathways with the pathophysiology of metabolic syndrome(MetS),type-2 diabetes mellitus and atherosclerosis.A high prevalence of steatosis ...
关键词：PSORIASIS Genetic polymorphisms METHOTREXATE Metabolic dysfunctionassociated steatotic liver disease Liver fibrosis Transient elastography 
Apigenin ameliorates CCl_(4)-induced hepatic fibrosis by inhibiting hepatic stellate cell activation via PI3K/AKT/GSK3βpathway in mice
《Asian Pacific Journal of Tropical Biomedicine》2025年第4期141-149,共9页Tao Sun Bao-Ying Wang Xiao-Ying Li Xiu-Zhi Zhang Yan-Fei Lei Shan-Fa Yu Ning-Ning Li 
supported by the grant from Henan Province Science and Technology Research Project(Project No:242102310250,222102310373);Key Research Project Program of Higher Education Institutions in Henan Province(NO 24A32006,22B360003);Medical Science and Technology Tackling Program of Henan Province(NO LHGJ20230677).
Objective:To investigate the effect of apigenin on carbon tetrachloride(CCl_(4))-induced liver fibrosis and elucidate the underlying mechanisms.Methods:A mouse model of CCl_(4)-induced liver fibrosis was used to evalu...
关键词：Liver fibrosis CCl_(4) Hepatic stellate cell PI3K/AKT/GSK3β APIGENIN 
Exploring the Efficacy of BMSC Transplantation via Various Pathways for Treating Cholestatic Liver Fibrosis in Mice
《Biomedical and Environmental Sciences》2025年第4期447-458,共12页Junjie Ren Zixu Li Xinrui Shi Tingting Lyu Xiaonan Li Min Ge Qizhi Shuai Tingjuan Huang 
supported by grants from the Natural Science Research Project of Shanxi Basic Research Program [20210302123246];the Scientific Research Project of Shanxi Provincial Health Commission [2020079];the Natural Science Foundation Youth Fund of Hebei Province[C2022402032];the Shanxi Province Higher Education “Billion Project” Science and Technology Guidance Project [BYJL036]。
Objective To compare the therapeutic efficacy of portal and tail vein transplantation of bone marrowderived mesenchymal stem cells(BMSCs) against cholestatic liver fibrosis in mice.Methods BMSCs were isolated and co-c...
关键词：Bone marrow mesenchymal stem cells Portal vein Tail vein Cholestatic hepatic fibrosis Administration route 
Global trends in artificial intelligence applications in liver disease over seventeen years
《World Journal of Hepatology》2025年第3期192-207,共16页Xue-Qin Zhou Shu Huang Xia-Min Shi Sha Liu Wei Zhang Lei Shi Mu-Han Lv Xiao-Wei Tang 
Supported by Natural Science Foundation of Sichuan Province,China,No.2022NSFSC1378.
BACKGROUND In recent years,the utilization of artificial intelligence(AI)technology has gained prominence in the field of liver disease.AIM To analyzes AI research in the field of liver disease,summarizes the current ...
关键词：Artificial intelligence Liver disease Hepatocellular carcinoma Liver fibrosis Bibliometric analysis 
Hepatic Surf4 Deficiency Impairs Serum Amyloid A1 Secretion and Attenuates Liver Fibrosis in Mice
《Research》2025年第1期921-934,共14页Bingxiang Wang Huili Li Govind Gill Xiangyan Zhang Geru Tao Boyan Liu Lei Zhai Wei Chen Hao Wang Hong-Mei Gu Shucun Qin Da-Wei Zhang 
supported by the National Natural Science Foundation of China(NSFC 81929002);a grant from the Canadian Institutes of Health Research(PS 178091);the Academic promotion program of Shandong First Medical University(2019QL010);the Natural Science Foundation of Shandong Province(ZR2021MH015);D.W.Z.was also supported by the Natural Sciences and Engineering Research Council of Canada(RGPIN-2016-06479);S.Q.was also supported by the Taishan Scholars Foundation of Shandong Province(ts201511057).
Liver fibrosis is a severe global health problem.However,no effective antifibrotic drugs have been approved.Surf4 is primarily located in the endoplasmic reticulum(ER)and mediates the transport of secreted proteins fr...
关键词：golgi apparatusknockout proteomics collagen antifibrotic drugs serum amyloid liver fibrosis endoplasmic reticulum er 
NUMB endocytic adaptor protein(NUMB)mediates the anti-hepatic fibrosis effect of artesunate(ART)by inducing senescence in hepatic stellate cells(HSCs)
《Chinese Journal of Natural Medicines》2025年第3期322-333,共12页Yangling Qiu Yujia Li Mengran Li Yingqian Wang Min Shen Jiangjuan Shao Feng Zhang Xuefen Xu Feixia Wang Zili Zhang Shizhong Zheng 
supported by the National Natural Science Foundation of China(Nos.82474164,82374124,82073914,82173874,82274185,82305046 and 82304902);the Natural Science Foundation of Jiangsu Province(Nos.BK20230458 and BK20220467);the General Project of the Natural Science Research of Jiangsu Higher Education Institutions(No.23KJB310017);Young Elite Scientists Sponsorship Program by CACM(No.2022-QNRC2-B15).
Developing and identifying effective medications and targets for treating hepatic fibrosis is an urgent priority.Our previous research demonstrated the efficacy of artesunate(ART)in alleviating liver fibrosis by elimi...
关键词：Hepatic stellate cells NUMB endocytic adaptor protein SENESCENCE ARTESUNATE UBIQUITYLATION Liver fibrosis 
Potential Protective or Pathogenic Roles of Parabacteroides distasonis in Diseases:A Narrative Review
《Infectious Microbes & Diseases》2025年第1期27-34,共8页Chaozhong Luo Hainv Gao 
supported by the National Key Research and Development Program(2021YFA1301104 and 2022YFC2304505);National Natural Science Foundation of China(81790634).
Parabacteroides distasonis is a gram-negative,non–spore-forming,rod-shaped,anaerobic bacterium,and an important gut colonizer first iso-lated from human feces in 1933.Over more than 90 years of research,P.distasonis ...
关键词：Parabacteroides distasonis antibiotic resistance liver fibrosis inflammatory bowel disease MECHANISM 
Patterns of liver fibrosis evolution in Chinese HIV/HBV co-infected adults following 5-year antiretroviral treatment:A longitudinal study using non-invasive APRI and Fib-4 scores
《Virologica Sinica》2025年第1期118-124,共7页Qingrong Zhang Lijun Sun Yuxuan Liang Wenlu Zou Jingtao Huang Yuan Zhang Yi Jin Na Zhou Jiangzhu Ye Huachun Zou Hao Wu Tong Zhang Bin Su Taiyi Jiang Haitao Chen 
financially supported by the National Natural Science Foundation of China(NSFC,82272312,82241072,82072271,and 82272319);the Shenzhen-Hong Kong-Macao Science and Technology Project(Category C project)(SGDX20220530111403024);the National Key R&D Program of China(2023YFC2307004,2021YFC2301900,and 2021YFC2301905);the 100 Top Talent Programs of Sun Yat-sen University(58000-12230029);the High-Level Public Health Specialized Talents Project of Beijing Municipal Health Commission(2022-2-018 and 2022-1-007);Beijing Health Technologies Promotion Program(BHTPP202002);the Climbing the peak(Dengfeng)Talent Training Program of Beijing Hospitals Authority(DFL20191701);Beijing Key Laboratory for HIV/AIDS Research(BZ0089).
The long-term effects of combined antiretroviral therapy(ART)on liver fibrosis patterns in adults living with human immunodeficiency virus(HIV)and chronic hepatitis B virus(HBV)are not well understood.Therefore,this s...
关键词：Human immunodeficiency virus(HIV) Chronic hepatitis B CO-INFECTION Liver fibrosis Trajectory analyses 
Modern ultrasound techniques for diagnosing liver steatosis and fibrosis:A systematic review with a focus on biopsy comparison
《World Journal of Hepatology》2025年第2期200-224,共25页Patryk Pozowski Mateusz Bilski Maciej Bedrylo PawełSitny Urszula Zaleska-Dorobisz 
Supported by Wroclaw Medical University’s Grant,No.SUBZ.C270.24.078.
BACKGROUND This review evaluated the diagnostic effectiveness of various ultrasound(US)methods compared to liver biopsy.AIM To determine the diagnostic accuracy of US techniques in assessing liver fibrosis and steatos...
关键词：Ultrasound diagnosis Liver steatosis Liver fibrosis Diagnostic accuracy Liver biopsy 
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