METABOLISM

作品数:1864被引量:5736H指数:32
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相关领域:医药卫生更多>>
相关作者:钟大放钱之玉王广基柳晓泉李燕更多>>
相关机构:沈阳药科大学中国科学院浙江大学清华大学更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划中国博士后科学基金北京市自然科学基金更多>>
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  • 期刊=Signal Transduction and Targeted Therapyx
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Clinical and biomarker analyses of SHR-1701 combined with famitinib in patients with previously treated advanced biliary tract cancer or pancreatic ductal adenocarcinoma:a phase II trial
《Signal Transduction and Targeted Therapy》2025年第1期328-339,共12页Lixia Yi Haoqi Pan Zhouyu Ning Litao Xu Hena Zhang Longfei Peng Yaowu Liu Yifan Yang Waimei Si Ying Wang Xiaoyan Zhu Shenglin Huang Zhiqiang Meng Jing Xie 
Advanced biliary tract cancer(BTC)and pancreatic ductal adenocarcinoma(PDAC)have poor prognoses and limited treatment options.Here,we conducted thisfirst-in-class phase II study to evaluate the efficacy and safety of ...
关键词:PATIENTS ADENOCARCINOMA METABOLISM 
Membraneless organelles in health and disease:exploring the molecular basis,physiological roles and pathological implications
《Signal Transduction and Targeted Therapy》2024年第12期5513-5538,共26页Yangxin Li Yuzhe Liu Xi-Yong Yu Yan Xu Xiangbin Pan Yi Sun Yanli Wang Yao-Hua Song Zhenya Shen 
supported by the National Natural Science Foundation of China(82370264 to Y.Li,82370501 to Y.H.S.,81870194 and 91849122 to Y.Li,92168203 to Z.S.);Project of State Key Laboratory of Radiation Medicine and Protection,Soochow University(No.GZK12023023 to Y.Li);Jiangsu Cardiovascular Medicine Innovation Center(CXZX202210);China Postdoctoral Science Foundation(No.2021M702394 to Y.W.);Jiangsu Funding Program for Excellent Postdoctoral Talent(No.2022ZB578 to Y.W.);The project for the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD);The National Key Research and Development Program of China(2022YFE0209700)to X.Y.Translational Research Grant of NCRCH(2020WSB07).
Once considered unconventional cellular structures,membraneless organelles(MLOs),cellular substructures involved in biological processes or pathways under physiological conditions,have emerged as central players in ce...
关键词:METABOLISM apparatus PHYSIOLOGICAL 
Gut microbial carcinogen metabolism:another avenue to cancer
《Signal Transduction and Targeted Therapy》2024年第11期4783-4784,共2页Florian R.Greten Melek C.Arkan 
Work in the lab of FRG and MCA is funded by institutional funds from the Georg-Speyer-Haus,the LOEWE Center Frankfurt Cancer Institute(FCI)funded by the Hessen State Ministry for Higher Education,Research and the Arts LOEWE,grants to FRG from the Deutsche Forschungsgemeinschaft(FOR2438:Gr1916/11-1,SFB1292-Project ID:318346496-TP16,SFB1479-Project ID:441891347-P02,GRK2336)the German Federal Ministry of Education;Research(BMBF,01KD2206Q/SATURN3);the European Research Council(Advanced Grant PLASTICAN-101021078).
A recent study published in Nature by Roje,Zhang and colleagues highlights the emergent role gut microbiota play in processing environmental carcinogens and raises its potential as a target for reducing cancer risk in...
关键词:METABOLISM CANCER pathogenesis 
Metabolic regulation of the immune system in health and diseases:mechanisms and interventions被引量:1
《Signal Transduction and Targeted Therapy》2024年第11期4904-4934,共31页Tengyue Hu Chang-Hai Liu Min Lei Qingmin Zeng Li Li Hong Tang Nannan Zhang 
supported by the National Natural Science Foundation(81970738);the Natural science foundation project of Sichuan(2024NSFSC0599);the Key Research and Development Program of Chengdu(2023-YF09-00052-SN);1.3.5 project for disciplines of excellence,West China Hospital,Sichuan University(No.ZYGD23030);the National Key Research and Development Program of China(No.2022YFC2304800).
Metabolism,including glycolysis,oxidative phosphorylation,fatty acid oxidation,and other metabolic pathways,impacts the phenotypes and functions of immune cells.The metabolic regulation of the immune system is importa...
关键词:METABOLISM DISEASES summarized 
Crossing epigenetic frontiers: the intersection of novel histone modifications and diseases被引量:1
《Signal Transduction and Targeted Therapy》2024年第10期4341-4378,共38页Weiyi Yao Xinting Hu Xin Wang 
National Natural Science Foundation(No.82270200,No.82070203 and No.81770210);Taishan Scholars Program of Shandong Province;Shandong Provincial Engineering Research Center of Lymphoma;Key Research and Development Program of Shandong Province(No.2018CXGC1213);Academic Promotion Programme of Shandong First Medical University(No.2019QL018);Translational Research Grant of NCRCH(No.2021WWB02,No.2020ZKMB01).
Histone post-translational modifications (HPTMs), as one of the core mechanisms of epigenetic regulation, are garnering increasing attention due to their close association with the onset and progression of diseases an...
关键词:DISEASES METABOLISM EPIGENETIC 
Glucagon-like peptide-1 receptor: mechanisms and advances in therapy被引量:4
《Signal Transduction and Targeted Therapy》2024年第10期4379-4407,共29页Zhikai Zheng Yao Zong Yiyang Ma Yucheng Tian Yidan Pang Changqing Zhang Junjie Gao 
National Natural Science Foundation of China(82002339,81820108020);Shanghai Frontiers Science Center of Degeneration and Regeneration in Skeletal System(BJ1-9000-22-4002).
The glucagon-like peptide-1(GLP-1)receptor,known as GLP-1R,is a vital component of the G protein-coupled receptor(GPCR)family and is found primarily on the surfaces of various cell types within the human body.This rec...
关键词:DRUGS METABOLISM MECHANISMS 
Metabolic inflexibility of mitochondria: beneficial for the fitness of regenerating liver cells
《Signal Transduction and Targeted Therapy》2024年第10期4154-4156,共3页Josef Ecker Sarah Brunner Klaus-Peter Janssen 
In a recent manuscript in Science,Wang and coworkers discovered that metabolic inflexibility is required for proper mitochondrial function during liver regeneration.1 This study deepens our understanding of liver meta...
关键词:METABOLISM LIVER METABOLIC 
Nascent mRNA damage:depot and disposal
《Signal Transduction and Targeted Therapy》2024年第9期3546-3547,共2页Mark Helm Marie-Luise Winz 
funded by Deutsche Forschungsgemeinschaft(DFG,German Research Foundation)[project number 439669440 TRR319 RMaP TP C01/C03 to M.H.TP B05 to M.-L.W.].
In a recent study published in Cell,Zhou et al.1 have characterized a highly unusual behavior of specialized stress granules(SG),driven by metabolism of UV-damaged pre-mRNA.These cytoplasmic SGs are characterized by a...
关键词:METABOLISM DAMAGE 
Targeting Lactobacillus johnsonii to reverse chronic kidney disease
《Signal Transduction and Targeted Therapy》2024年第9期4030-4047,共18页Hua Miao Fei Liu Yan-Ni Wang Xiao-Yong Yu Shougang Zhuang Yan Guo Nosratola D.Vaziri Shi-Xing Ma Wei Su You-Quan Shang Ming Gao Jin-Hua Zhang Li Zhang Ying-Yong Zhao Gang Cao 
supported by National Natural Science Foundation of China(Nos.82074002,82274079,82274192,32100631);Shaanxi Key Science and Technology Plan Project(No.2023-ZDLSF-26);Macao Young Scholars Program(No.AM2023024);China Postdoctoral Science Foundation(No.2023T160061);Capital’s Funds for Health Improvement and Research(No.2024-4-40215);Natural Science Foundation of Zhejiang Province(No.LZ22H280001).
Accumulated evidence suggested that gut microbial dysbiosis interplayed with progressive chronic kidney disease(CKD).However,no available therapy is effective in suppressing progressive CKD.Here,using microbiomics in ...
关键词:KIDNEY METABOLISM protective 
Ribosomal modification protein rimK-like family member A activates betaine-homocysteine S-methyltransferase 1 to ameliorate hepatic steatosis
《Signal Transduction and Targeted Therapy》2024年第9期4048-4065,共18页Han Yan Wenjun Liu Rui Xiang Xin Li Song Hou Luzheng Xu Lin Wang Dong Zhao Xingkai Liu Guoqing Wang Yujing Chi Jichun Yang 
supported by National Natural Science Foundation of China(82300957/82230024/82025008/82070844);Beijing Natural Science Foundation(7212123).
Nonalcoholic fatty liver disease(NAFLD)is a serious threat to public health,but its underlying mechanism remains poorly understood.In screening important genes using Gene Importance Calculator(GIC)we developed previou...
关键词:METABOLISM HEPATIC HOMOCYSTEINE 
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