Advanced biliary tract cancer(BTC)and pancreatic ductal adenocarcinoma(PDAC)have poor prognoses and limited treatment options.Here,we conducted thisfirst-in-class phase II study to evaluate the efficacy and safety of ...
supported by the National Natural Science Foundation of China(82370264 to Y.Li,82370501 to Y.H.S.,81870194 and 91849122 to Y.Li,92168203 to Z.S.);Project of State Key Laboratory of Radiation Medicine and Protection,Soochow University(No.GZK12023023 to Y.Li);Jiangsu Cardiovascular Medicine Innovation Center(CXZX202210);China Postdoctoral Science Foundation(No.2021M702394 to Y.W.);Jiangsu Funding Program for Excellent Postdoctoral Talent(No.2022ZB578 to Y.W.);The project for the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD);The National Key Research and Development Program of China(2022YFE0209700)to X.Y.Translational Research Grant of NCRCH(2020WSB07).
Once considered unconventional cellular structures,membraneless organelles(MLOs),cellular substructures involved in biological processes or pathways under physiological conditions,have emerged as central players in ce...
Work in the lab of FRG and MCA is funded by institutional funds from the Georg-Speyer-Haus,the LOEWE Center Frankfurt Cancer Institute(FCI)funded by the Hessen State Ministry for Higher Education,Research and the Arts LOEWE,grants to FRG from the Deutsche Forschungsgemeinschaft(FOR2438:Gr1916/11-1,SFB1292-Project ID:318346496-TP16,SFB1479-Project ID:441891347-P02,GRK2336)the German Federal Ministry of Education;Research(BMBF,01KD2206Q/SATURN3);the European Research Council(Advanced Grant PLASTICAN-101021078).
A recent study published in Nature by Roje,Zhang and colleagues highlights the emergent role gut microbiota play in processing environmental carcinogens and raises its potential as a target for reducing cancer risk in...
supported by the National Natural Science Foundation(81970738);the Natural science foundation project of Sichuan(2024NSFSC0599);the Key Research and Development Program of Chengdu(2023-YF09-00052-SN);1.3.5 project for disciplines of excellence,West China Hospital,Sichuan University(No.ZYGD23030);the National Key Research and Development Program of China(No.2022YFC2304800).
Metabolism,including glycolysis,oxidative phosphorylation,fatty acid oxidation,and other metabolic pathways,impacts the phenotypes and functions of immune cells.The metabolic regulation of the immune system is importa...
National Natural Science Foundation(No.82270200,No.82070203 and No.81770210);Taishan Scholars Program of Shandong Province;Shandong Provincial Engineering Research Center of Lymphoma;Key Research and Development Program of Shandong Province(No.2018CXGC1213);Academic Promotion Programme of Shandong First Medical University(No.2019QL018);Translational Research Grant of NCRCH(No.2021WWB02,No.2020ZKMB01).
Histone post-translational modifications (HPTMs), as one of the core mechanisms of epigenetic regulation, are garnering increasing attention due to their close association with the onset and progression of diseases an...
National Natural Science Foundation of China(82002339,81820108020);Shanghai Frontiers Science Center of Degeneration and Regeneration in Skeletal System(BJ1-9000-22-4002).
The glucagon-like peptide-1(GLP-1)receptor,known as GLP-1R,is a vital component of the G protein-coupled receptor(GPCR)family and is found primarily on the surfaces of various cell types within the human body.This rec...
In a recent manuscript in Science,Wang and coworkers discovered that metabolic inflexibility is required for proper mitochondrial function during liver regeneration.1 This study deepens our understanding of liver meta...
funded by Deutsche Forschungsgemeinschaft(DFG,German Research Foundation)[project number 439669440 TRR319 RMaP TP C01/C03 to M.H.TP B05 to M.-L.W.].
In a recent study published in Cell,Zhou et al.1 have characterized a highly unusual behavior of specialized stress granules(SG),driven by metabolism of UV-damaged pre-mRNA.These cytoplasmic SGs are characterized by a...
supported by National Natural Science Foundation of China(Nos.82074002,82274079,82274192,32100631);Shaanxi Key Science and Technology Plan Project(No.2023-ZDLSF-26);Macao Young Scholars Program(No.AM2023024);China Postdoctoral Science Foundation(No.2023T160061);Capital’s Funds for Health Improvement and Research(No.2024-4-40215);Natural Science Foundation of Zhejiang Province(No.LZ22H280001).
Accumulated evidence suggested that gut microbial dysbiosis interplayed with progressive chronic kidney disease(CKD).However,no available therapy is effective in suppressing progressive CKD.Here,using microbiomics in ...
supported by National Natural Science Foundation of China(82300957/82230024/82025008/82070844);Beijing Natural Science Foundation(7212123).
Nonalcoholic fatty liver disease(NAFLD)is a serious threat to public health,but its underlying mechanism remains poorly understood.In screening important genes using Gene Importance Calculator(GIC)we developed previou...