MITOCHONDRIAL

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ANT2 functions as a translocon for mitochondrial cross-membrane translocation of RNAs被引量：2
《Cell Research》2024年第7期504-521,共18页Pengcheng Wang Lixiao Zhang Siyi Chen Renjian Li Peipei Liu Xiang Li Hongdi Luo Yujia Huo Zhirong Zhang Yiqi Cai Xu Liu Jinliang Huang Guangkeng Zhou Zhe Sun Shanwei Ding Jiahao Shi Zizhuo Zhou Ruoxi Yuan Liang Liu Sipeng Wu Geng Wang 
the Priority Research Program of the Ministry of Science and Technology of China(2017YFA0504600);the National Natural Science Foundation of China(91649103 and 32091159).
Bidirectional transcription of mammalian mitochondrial DNA generates overlapping transcripts that are capable of forming double-stranded RNA(dsRNA)structures.Release of mitochondrial dsRNA into the cytosol activates t...
关键词：FUNCTIONS checked RELEASE 
Mitochondrial PD-L1 modulates cancer immunotherapy被引量：1
《Cell Research》2023年第5期335-336,共2页Xiaoming Dai Jing Liu Wenyi Wei 
The expression and subcellular localization of immune checkpoint protein PD-L1 have been implicated to play an important role in cancer immunotherapy.In a recent paper published in Cell Research,Xie et al.report that ...
关键词：IMMUNOTHERAPY CANCER al. 
SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors被引量：6
《Cell Research》2022年第7期638-658,共21页Xiaomin Wang Ziqi Chen Jun Xu Shuai Tang Nan An Lei Jiang Yixiang Zhang Shaoying Zhang Qingli Zhang Yanyan Shen Shijie Chen Xiaojing Lan Ting Wang Linhui Zhai Siyuwei Cao Siqi Guo Yingluo Liu Aiwei Bi Yuehong Chen Xiameng Gai Yichen Duan Ying Zheng Yixian Fu Yize Li Liang Yuan Linjiang Tong Kun Mo Mingcheng Wang Shu-Hai Lin Minjia Tan Cheng Luo Yi Chen Jia Liu Qiansen Zhang Leping Li Min Huang 
supported by the National Natural Science Foundation of China(81821005,91957126,81903640,91957120);the Program of Shanghai Academic Research Leader(20XD1424800).
Muta nt isocitrate dehydrog en ase 1(mlDH1)drives tumorigenesis via produci ng on cometabolite R-2-hydroxyglutarate(R-2-HG)across various tumor types.However,mlDHl in hibitors appear only effective in hematological tu...
关键词：IDH1 1A1 ANGIOGENESIS 
Cuproptosis:a copper-triggered modality of mitochondrial cell death被引量：54
《Cell Research》2022年第5期417-418,共2页Daolin Tang Xin Chen Guido Kroemer 
Various heavy metals can induce regulated cell death through different subroutines.A recent study published in Science found that intracellular copper accumulation triggers the aggregation of mitochondrial lipoylated ...
关键词：DEATH ROUTINE PEROXIDATION 
Solution structure of the voltage-gated Tim23 channel in complex with a mitochondrial presequence peptide
《Cell Research》2021年第7期821-824,共4页Shu Zhou Maosen Ruan Yunyan Li Jing Yang Suwen Bai Christian Richter Harald Schwalbe Can Xie Bing Shen Junfeng Wang 
supported by the High Magnetic Field Laboratory of Anhui Province;This study was supported by grants from the Ministry of Science and Technology of China(Grant No.,2016YFA0400901);the National Natural Science Foundation of China(Grant No.,U1632274);Hefei Science Center of Chinese Academy of Sciences(Grant No.,2020HSC-CIP011);by iNEXT-Discovery,project number 871037,funded by the Horizon 2020 program of the European Commission.
Dear Editor,Most mitochondrial proteins are synthesized in the cytosol and transported into various mitochondrial subcompartments in a process that is mediated by intricate multimeric machineries.Tim23,the key compone...
关键词：SEQUENCE CONDUCTING structure 
Structure of the mitochondrial TIM22 complex from yeast
《Cell Research》2021年第3期366-368,共3页Yutong Zhang Xiaomin Ou Xuezheng Wang Dongjie Sun Xueyin Zhou Xiaofei Wu Qing Li Long Li 
Computation was supported by the High-performance Computing Platform of Peking University.Q.L.is supported by Beijing Outstanding Young Scientist Program(BJJWZYJH01201910001005).
Dear Editor,Mitochondria have more than 1000 proteins,most of which are encoded by nuclear DNA and imported from the cytosol.1 A large group of multi-spanning membrane proteins,the solute carrier proteins,are imported...
关键词：COMPLEX LIKELY IMPORTED 
Cryo-EM structure of the human mitochondrial translocase TIM22 complex被引量：1
《Cell Research》2021年第3期369-372,共4页Liangbo Qi Qiang Wang Zeyuan Guan Yan Wu Cuicui Shen Sixing Hong Jianbo Cao Xing Zhang Chuangye Yan Ping Yin 
This work was supported by funds from the Ministry of Science and Technology of China(2018YFA0507700);the National Natural Science Foundation of China(31722017);the Fok Ying-Tong Education Foundation(151021);the Fundamental Research Funds for the Central Universities(2662017PY031);This research was supported by Beijing Advanced Innovation Center for Structural Biology(to Dr.Chuangye Yan).
Dear Editor,Mitochondria are essential organelles in cellular metabolism,homeostasis,and apoptosis.1,2 Most mitochondrial proteins are synthesized as precursors in the cytosol and then imported into mitochondria by sp...
关键词：TRANS INNER COMPLEXES 
Mitochondrial replacement in macaque monkey offspring by first polar body transfer被引量：6
《Cell Research》2021年第2期233-236,共4页Zhanyang Wang Yuzhuo Li Xianfa Yang Yan Wang Yanhong Nie Yuting Xu Xiaotong Zhang Yong Lu Tikui Zhang Qiming Liu Naihe Jing Zhen Liu Qiang Sun 
the National Key R&D Program of China(2018YFC1003000 to Q.S.and Z.L.);the National Natural Science Foundation of China(31825018 to Q.S.);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB32060100 to Q.S.);the Shanghai Municipal Science and Technology Major Project(2018SHZDZX05 to Q.S.);the Shanghai Municipal Government Bureau of Science and Technology(18JC1410100 to Q.S.);Shanghai Young Talents Sailing Program(18YF1427500 to Z.L.).
Dear Editor,Mitochondrial DNA(mtDNA)mutations are materally inherited to the offspring and mitochondrial replacement therapy(MRT)provides.a promising approach for preventing mtDNA-related 1,2 diseases.First polar body...
关键词：MITOCHONDRIAL OFFSPRING REPLACEMENT 
Author Correction:Mitochondrial DNA synthesis fuels NLRP3 inflammasome被引量：1
《Cell Research》2018年第12期1202-1202,共1页Rebecca C.Coll Caroline L.Holley Kate Schroder 
In the initial published version of this article,there was a mistake in the title.The correct title should be "Mitochondrial DNA synthesis fuels NLRP3 activation".This correction does not affect the description of the...
关键词：AUTHOR CORRECTION MITOCHONDRIAL DNA SYNTHESIS fuels NLRP3 INFLAMMASOME 
Mitochondrial DNA synthesis fuels NLRP3 inflammasome被引量：3
《Cell Research》2018年第11期1046-1047,共2页Rebecca C. Coll Caroline L. Holley Kate Schroder 
Mitochondria-derived signals are associated with NLRP3 inflammasome activation. A recent study in Nature by Zhong et al. shows that inflammasome priming drives new mito- chondrial DNA synthesis, and proposes this to b...
关键词：Innate immunity 
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