MITOCHONDRIAL

作品数：880被引量：2426H指数：17
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相关领域：医药卫生生物学更多>>
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相关机构：北京大学中国科学院中国人民解放军总医院中国科学院遗传与发育生物学研究所更多>>
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Targeting metabolism to improve CAR-T cells therapeutic efficacy被引量：1
《Chinese Medical Journal》2024年第8期909-920,共12页Shasha Liu Yuyu Zhao Yaoxin Gao Feng Li Yi Zhang 
National Key Research and Development Program Intergovernmental Key Project for International Science and Technology Innovation Cooperation(No.2022YFE0141000);Natural Science Foundation of China(No.82203548);China Postdoctoral Science Foundation Project(No.2022M712894);Medical Science and Technology Project of Henan Province(No.LHGJ20220385);Major science and technology project of Henan Province(No.221100310100)
Chimeric antigen receptor T(CAR-T)cell therapy achieved advanced progress in the treatment of hematological tumors.However,the application of CAR-T cell therapy for solid tumors still faces many challenges.Competition...
关键词：CAR-T cell therapy METABOLISM Tumor microenvironment IMMUNOTHERAPY Mitochondrial fitness 
1,12-cyclic apelin-12 ameliorates Ang II and Apelin-13-induced cardiac hypertrophy by reducing mitochondrial oxidative damage被引量：1
《Chinese Medical Journal》2024年第6期749-751,共3页Xueqian Ouyang Wei Chen Guolong Peng Huimei Liu Sisi Fan Qin Li Liwen Wang Linxi Chen Lanfang Li 
supported by grants from the National Natural Science Foundation of China(No.81970431);the Hunan Provincial Natural Science Foundation of China(No.2023JJ50136)
To the Editor:Pathological cardiac hypertrophy is commonly stimulated by stress or induced by cardiovascular diseases,such as hypertension and myocardial infarction.A sustained pathological hypertrophic response can l...
关键词：HYPERTROPHY CARDIAC ANG 
Dihydroartemisinin-induced mitochondrial mRNA degradation and apoptosis in keloid fibroblasts被引量：1
《Chinese Medical Journal》2022年第13期1613-1615,共3页Qijie Li Ping Wu Yiqing Xia Dunshui Liao Yunxia Zuo Junliang Wu Qingjie Xia 
supported by China Postdoctoral Science Foundation(No.2019M653413),Post-Doctor Research Project,West China Hospital,Sichuan University(No.2018HXBH082);the Key Project Research and Invention Program of Science and Technology Department of Sichuan Province(No.2021YFS0245)。
To the Editor:Keloid is a type of proliferative fibroma that may form after trauma.It is characterized by an exacerbated proliferation and inhibited apoptosis of fibroblasts coupled with an imbalance between synthesis...
关键词：inhibited LUNG INHIBITING 
CHCHD2 maintains mitochondrial contact site and cristae organizing system stability and protects against mitochondrial dysfunction in an experimental model of Parkinson’s disease
《Chinese Medical Journal》2022年第13期1588-1596,共9页Lin Lu Hengxu Mao Miaomiao Zhou Yuwan Lin Wei Dai Jiewen Qiu Yousheng Xiao Mingshu Mo Xiaoqin Zhu Zhuohua Wu Zhong Pei Wenyuan Guo Pingyi Xu Xiang Chen 
supported by research grants from the National Natural Science Foundation of China(Nos.81901282,81870992,82071444);the Nature Science Foundation of Guangdong Province(Nos.2019A1515011189,2020A1515010985);the Technology Project of Guangzhou(Nos.202102020029,2019ZD09).
Background:Parkinson’s disease(PD)is the second most common neurodegenerative disease after Alzheimer’s dementia.Mitochondrial dysfunction is involved in the pathology of PD.Coiled-coil-helix-coiled-coil-helix domai...
关键词：CHCHD2 MICOS complex Mic10 Parkinson’s disease 
Electrical stimulation induces mitochondrial autophagy via activating oxidative stress and Sirt3 signaling pathway
《Chinese Medical Journal》2021年第5期628-630,共3页He-Ling Dong Hong-Yuan Wu Zhen-Xiang Tian Zhi Luo Yi-Fen Wu Jun Zhao 
This work was supported by grants from the National Youth Science Fund Project of National Natural Science Foundation of China(No.81803877);the Natural Science Foundation of Guangdong Province of China(No.2017A030310178).
To the Editor:Mitochondrial function is one of the most cutting edge fields in the current research and further study is needed to investigate the specifc signaling mechanisms of mitochondrial function.A previous stud...
关键词：STIMULATION metabolism OXIDATIVE 
Mitochondrial transfer from bone-marrow-derived mesenchymal stromal cells to chondrocytes protects against cartilage degenerative mitochondrial dysfunction in rats chondrocytes被引量：3
《Chinese Medical Journal》2021年第2期212-218,共7页Rui Wang Talatibaike Maimaitijuma Yuan-Yuan Ma Yang Jiao Yong-Ping Cao 
supported by a grant from the Scientific Research Seed Fund of Peking University First Hospital(No.2018SF020)。
Background:Previous studies have reported that mitochondrial dysfunction participates in the pathological process of osteoarthritis(OA).However,studies that improve mitochondrial function are rare in OA.Mitochondrial ...
关键词：Mitochondrial transfer Osteoarthritis Mitochondrial dysfunction CHONDROCYTE BM-MSCs 
Multisystem involvement in Chinese patients with neuromyopathic phenotype of mitochondrial trifunctional protein deficiency被引量：1
《Chinese Medical Journal》2020年第11期1358-1360,共3页Cui-Jie Wei Xing-Zhi Chang Lin Ge Xiao-Na Fu Yan-Bin Fan Jie-Yu Liu Shuang Wang Hai-Li Li Yan-Ling Yang Hui Xiong 
This work was supported by grants from the National Key Research and Development Program of China(No.2016YFC0901505);the National Natural Science Foundation of China(No.81571220);the Beijing Key Laboratory of Molecular Diagnosis and Study on Pediatric Genetic Diseases(No.Z141107004414036,BZ0317).
Mitochondrial trifunctional protein(MTP)is a multienzyme complex,which catalyzes the last three steps of mitochondrial p-oxidation of the long-chain fatty acids.Structurally,MTP consists of four a-subunits and four P-...
关键词：INVOLVEMENT HEPATIC PATIENTS 
Overexpression of transcription factor EB regulates mitochondrial autophagy to protect lipopolysaccharide-induced acute lung injury被引量：9
《Chinese Medical Journal》2019年第11期1298-1304,共7页Wei Liu Cong-Cong Li Xi Lu Li-Yan Bo Fa-Guang Jin 
Natural Science Foundation of China (No.81600053).
Background:Acute lung injury (ALI) is characterized by an acute inflammatory process, and oxidative stress in the lung tissue leads to a lack of effective therapeutics. This study aimed to identify whether the overexp...
关键词：Transcription factor EB MITOCHONDRIAL AUTOPHAGY Acute lung injury Inflammation MITOCHONDRIAL damage 
Mortality in mitochondrial encephalomyopathy,lactic acidosis,and stroke-like episodes does not depend on levetirazetam alone被引量：1
《Chinese Medical Journal》2019年第12期1512-1512,共1页Josef Finsterer 
We appreciated reading the article by Zhang et al[1] about a retrospective study of 102 mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) patients with epilepsy in which disability and...
关键词：MORTALITY in MITOCHONDRIAL ENCEPHALOMYOPATHY levetirazetam ALONE 
Activated mTOR signaling pathway in myofibers with inherited metabolic defect might be an evidence for mTOR inhibition therapies被引量：1
《Chinese Medical Journal》2019年第7期805-810,共6页Jing-Wei Lyu Xue-Bi Xu Kun-Qian Ji Na Zhang Yuan Sun Dan-Dan Zhao Yu-Ying Zhao Chuan-Zhu Yan 
Background:Abnormally activated mechanistic target of rapamycin(mTOR)pathway has been reported in several model animals with inherited metabolic myopathies(IMMs).However,the profiles of mTOR pathway in skeletal muscle...
关键词：MTOR pathway MITOCHONDRIAL MYOPATHY Lipid storage DISEASE Pompe DISEASE 
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