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高等学校学科创新引智计划(111-2-12): 作品数：10被引量：79H指数：5; 导出分析报告; 相关作者：李桂源唐珂喻正源卢建红俞海波更多>>; 相关机构：中南大学中南大学湘雅二医院桂林医学院更多>>; 相关期刊：《Science China(Life Sciences)》《生物化学与生物物理进展》《中南大学学报（医学版）》《Signal Transduction and Targeted Therapy》更多>>; 相关主题：NASOPHARYNGEAL_CARCINOMA鼻咽癌METABOLISMGUTIMMUNITY更多>>; 相关领域：医药卫生生物学更多>>

Circular RNA circCCNB1 inhibits the migration and invasion of nasopharyngeal carcinoma through binding and stabilizing TJP1 mRNA被引量：5: 《Science China(Life Sciences)》2022年第11期2233-2247,共15页Mengyao Zhao Yian Wang Fenghua Tan Lingyun Liu Xiangchan Hou Chunmei Fan Le Tang Yongzhen Mo Yumin Wang Qijia Yan Zhaojian Gong Zheng Li Qianjin Liao Can Guo He Huang Xi Zeng Guiyuan Li Zhaoyang Zeng Wei Xiong Fuyan Wang; the National Natural Science Foundation of China(82002239,82072374 and 82073135);the Overseas Expertise Introduction Project for Discipline Innovation(111 Project,111-2-12);the Natural Science Foundation of Hunan Province(2021JJ41043 and 2021JJ30897);Central South University Graduate Research and Innovation Project(2021zzts0310)。; Nasopharyngeal carcinoma(NPC)is a malignant tumor that usually occurs in people from Southeast Asia and Southern China.NPC is prone to migration and invasion,leading to poor prognosis.A large number of circular RNAs(c...; 关键词：nasopharyngeal carcinoma circCCNB1 NF90 TJP1 migration and invasion

Long non-coding RNA AFAP1-AS1 accelerates lung cancer cells migration and invasion by interacting with SNIP1 to upregulate c-Myc被引量：9: 《Signal Transduction and Targeted Therapy》2021年第7期2225-2237,共13页Yu Zhong Liting Yang Fang Xiong Yi He Yanyan Tang Lei Shi Songqing Fan Zheng Li Shanshan Zhang Zhaojian Gong Can Guo Qianjin Liao Yujuan Zhou Ming Zhou Bo Xiang Xiaoling Li Yong Li Zhaoyang Zeng Guiyuan Li Wei Xiong; This study was funded by the National Natural Science Foundation of China(82073135,81903015 and 81772928);the Overseas Expertise Introduction Project for Discipline Innovation(111 Project,No.111-2-12);the Natural Science Foundation of Hunan Province(20191)50780 and 2019JJ50872).; Actin filament associated protein 1 antisense RNA 1(named AFAP1-AS1)is a long non-coding RNA and overexpressed in many cancers.This study aimed to identify the role and mechanism of AFAP1-AS1 in lung cancer.The AFAP1-...; 关键词：INVASION LUNG METASTASIS

The cross-talk between methylation and phosphorylation in lymphoid-specific helicase drives cancer stem-like properties: 《Signal Transduction and Targeted Therapy》2020年第1期670-683,共14页Na Liu Rui Yang Ying Shi Ling Chen Yating Liu Zuli Wang Shouping Liu Lianlian Ouyang Haiyan Wang Weiwei Lai Chao Mao Min Wang Yan Cheng Shuang Liu Xiang Wang Hu Zhou Ya Cao Desheng Xiao Yongguang Tao; supported by the National Natural Science Foundation of China[81672991 and 81874139 to S.L.,81872285 to Y.S.,81728014 to Y.T.,81672787 to Y.T.,81672307 to X.W,81772927 to D.X.];the National Basic Research Program of China[2015CB553903 to Y.T.];the Overseas Expertise Introduction Project for Discipline Innovation(111 Project,No.111-2-12);the Fundamental Research Funds for the Central Universities[2017zzts206 to N.L.].; Posttranslational modifications(PTMs)of proteins,including chromatin modifiers,play crucial roles in the dynamic alteration of various protein properties and functions including stem-cell properties.However,the roles ...; 关键词：CANCER residue PHOSPHORYLATION

Regulating tumor suppressor genes:post-translational modifications被引量：11: 《Signal Transduction and Targeted Therapy》2020年第1期1688-1712,共25页Ling Chen Shuang Liu Yongguang Tao; supported by the National Natural Science Foundation of China[81672787(Y.Tao),81874139 and 81672991(S.Liu)];the Overseas Expertise Introduction Project for Discipline Innovation(111 Project,No.111-2-12).; Tumor suppressor genes cooperate with each other in tumors.Three important tumor suppressor proteins,retinoblastoma(Rb),p53,phosphatase,and tensin homolog deleted on chromosome ten(PTEN)are functionally associated and...; 关键词：SUPPRESSOR TRANSLATIONAL PRECISE

Demystifying the manipulation of host immunity, metabolism, and extraintestinal tumors by the gut microbiome被引量：30: 《Signal Transduction and Targeted Therapy》2019年第1期264-297,共34页Ziying Zhang Haosheng Tang Peng Chen Hui Xie Yongguang Tao; This work was supported by the National Natural Science Foundation of China(81672787[Y.T.]);the National Basic Research Program of China(2015CB553903[Y.T.]);an the Overseas Expertise Introduction Project for Discipline Innovation(111 Project,No.111-2-12).; The trillions of microorganisms in the gut microbiome have attracted much attention recently owing to their sophisticated and widespread impacts on numerous aspects of host pathophysiology.Remarkable progress in large...; 关键词：METABOLISM IMMUNITY MANIPULATION

稳定转染NOR1抑制5-8F细胞片状伪足形成和Wnt信号通路被引量：2: 《生物化学与生物物理进展》2012年第9期887-892,共6页向波王卫李文娟唐珂曾朝阳李小玲李桂源; 国家自然科学基金(81000883;81272254;81102065;30971147;81171930;30871282);高等学校学科创新引智计划(111-2-12);湖南省科技计划(2011FJ3111;10JJ7003);中南大学自由探索计划(201012200017;2011QNZT138);中南大学研究生教育创新工程(2010ssxt048;CX2011B051)资助项目~~; 细胞骨架是真核细胞中的蛋白纤维网络结构,不仅与保持细胞形态结构有关,而且影响细胞黏附和细胞运动.NOR1是从鼻咽癌中克隆得到的新基因,在鼻咽癌组织和细胞系中表达下调.本研究建立了NOR1稳定表达的鼻咽癌5-8F细胞系.过表达NOR1引起高...; 关键词：NOR1 鼻咽癌片状伪足 WNT信号通路

Nasopharyngeal carcinoma:Advances in genomics and molecular genetics被引量：13: 《Science China(Life Sciences)》2011年第10期966-975,共10页ZENG ZhaoYang HUANG HongBin ZHANG WenLing XIANC Bo ZHOU Ming ZHOU YanHong MA Jian YI Mei LI XiaYu LI XiaoLing XIONG Wei LI GuiYuan; supported by the National Natural Science Foundation of China (Grant Nos.30871282,30871365,30971147,81000883,81000972,81071644,81071686,81071756,81171930,81171931,81171934,81171988,81172189,81101509,and 81102065);the 111 Project (Grant No.111-2-12);the Natural Science Foundation of Hunan Province (Grant Nos.10JJ7003,11JJ1013,11JJ22043 and 11JJ4072);the Fundamental Research Funds for the Central Universities; Nasopharyngeal carcinoma （NPC） is a squamous-cell carcinoma that arises in the epithelial lining of the nasopharynx [1]. This neoplasm has a notable ethnic and geographic distribution, being of high prevalence in so...; 关键词：鼻咽癌分子遗传学基因组学全国人民代表大会病毒DNA EB病毒鳞状细胞癌地域分布

EB病毒潜伏感染基因组在上皮肿瘤细胞克隆扩增中的保留(英文): 《中南大学学报（医学版）》2011年第7期624-630,共7页晏其佳俞海波卢建红喻正源左埒莲李桂源; supported by the Project of Development and Reform Commission of Hunan Province(2009-13910);the 111 Project(111-2-12),P.R.China; 目的:探讨EBV感染的上皮细胞在克隆扩增过程中细胞中EBV基因组保留或丢失的实质。方法:使用EBV潜伏感染的上皮肿瘤细胞系293-EBV,其中的EBV基因组通过绿色荧光蛋白(green fluores-cent protein,GFP)示踪,经过多次传代使细胞的GFP表达强...; 关键词：EB病毒基因组潜伏感染上皮肿瘤细胞克隆扩增保留

GFP示踪观察移植瘤原代培养细胞的生长规律被引量：2: 《生物化学与生物物理进展》2011年第6期563-567,共5页左埒莲卢建红俞海波喻正源晏其佳何威唐珂李桂源; 国家重大科学研究计划(2006CB910502);湖南省发改委研发项目(2009-13910);高等学校学科创新引智计划(111-2-12)~~; 采用GFP稳定表达的细胞系(293-BAC)接种裸鼠形成移植瘤.取肿瘤组织进行原代培养,通过GFP示踪和细胞形态学变化,观察了肿瘤组织中细胞的生长规律.肿瘤细胞释放并生长在组织块附近,向周围空间延伸.种植时散落的薄层组织细胞则直接贴壁生长...; 关键词：移植瘤原代培养生长 GFP示踪

组织微阵列技术研究肿瘤转移相关基因在鼻咽癌中的表达与临床意义被引量：11: 《生物化学与生物物理进展》2009年第5期616-623,共8页范松青张文玲徐丽娜周艳宏李桂源; 国家重大科学研究计划(973)(2006CB910502,2006CB910504);国家高技术研究发展计划(863)(2007AA02Z170);高等学校创新引智计划(111-2-12);湖南省自然科学基金(06JJ2013)资助项目~~; 利用高通量组织微阵列结合免疫组化检测MT1-MMP、MT2-MMP、Ezrin、nm23-H1、E-cad和TIMP-2在鼻咽癌组织中的蛋白质表达,探讨肿瘤转移相关基因异常表达在鼻咽癌侵袭转移中的作用,筛选鼻咽癌转移相关分子标志物.结果发现,鼻咽癌组织存在MT...; 关键词：肿瘤转移相关基因鼻咽癌组织微阵列免疫组化

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