国家自然科学基金(30170270)

作品数:29被引量:141H指数:7
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相关作者:郑启新郭晓东刘勇段德宇杜靖远更多>>
相关机构:华中科技大学中山大学首都医科大学附属北京友谊医院郑州市骨科医院更多>>
相关期刊:《中国矫形外科杂志》《中华实验外科杂志》《Journal of Wuhan University of Technology(Materials Science)》《北京航空航天大学学报》更多>>
相关主题:转化生长因子Β1间充质干细胞PLGA成骨细胞基因修饰更多>>
相关领域:医药卫生生物学理学航空宇航科学技术更多>>
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加力燃烧室NO_x排放生成规律试验分析
《北京航空航天大学学报》2012年第8期1005-1009,共5页王琦 胡筱敏 
国家自然科学基金重点资助项目(69735101);国家自然科学基金资助项目(30170270)
实现航空发动机大推力通常采用加力燃烧室设计,燃烧室进气温度升高会同步导致排放尾气中NOx浓度提高.采用典型加力燃烧室主稳定器的V型结构试验件,测试加力燃烧前后(进口600℃,出口600~1200℃)燃烧室排放断面的NOx浓度分布,通过相同流...
关键词:NOX排放 加力燃烧室 断面浓度分布 生成抑制 
The Enhancement of Osteogenesis by Scaffold Based on Mineralized Recombinant Human-like Collagen Loading with rhBMP-2
《Journal of Wuhan University of Technology(Materials Science)》2009年第6期956-960,共5页吴斌 郑启新 
Funded by the National Natural Science Foundation of China(No.30170270);the National High-tech Research Program (863)(No. 2006AA320605)
A biomimetic scaffold based on mineralized recombinant collagen, nano-hydroxyapatite/recombinant human-like collagen/poly(lactic acid) (nHA/RHLC/PLA), was prepared with recombinant human bone morphogenic protein-2...
关键词:RHBMP-2 bone tissue engineering OSTEOGENESIS biomaterial 
Biomineralization of the Surface of PLGA-(ASP-PEG) Modified with the K_(16) and RGD-containing Peptide被引量:1
《Journal of Wuhan University of Technology(Materials Science)》2009年第5期768-771,共4页郝杰 郑启新 
Funded by the National Natural Science Foundation of China (No.30170270, 30200063)
K16 and RGD-containing peptide was used to modify the surface of three-dimensional PLGA-(ASP-PEG) matrix, then the modified PLGA-(ASP-PEG) was incubated in modified simulated body fluid (SBF). The biomineralizat...
关键词:BIOMINERALIZATION PLGA hydroxyapatite (HA) PEPTIDE 
Repair of Rabbit Femoral Defects with a Novel BMP2-derived Oligopeptide P24
《Journal of Huazhong University of Science and Technology(Medical Sciences)》2008年第4期426-430,共5页段智霞 郑启新 郭晓东 李长文 吴斌 伍卫刚 
the National Natural Sciences Foundation of China (Nos. 30470483, 30200063, 30170270);a Program for New Century Excellent Talents (NCET) in University from the Ministry of Education of China (No. 20045006071-10)
In this study, the bioactivity of a novel BMP2-derived oligopeptide P24 was investigated by using the model of rabbit femoral defect after loaded in the biodegradable poly (lactic acid / glycolic acid / asparagic aci...
关键词:BMP2 oligopeptide P24 bone regeneration PLGA-[ASP-PEG] 
含Arg-Gly-Asp肽与仿生PLGA-(ASP-PEG)材料结合的实验研究被引量:2
《生物医学工程学杂志》2008年第4期860-863,共4页宋玉林 郑启新 郭晓东 郝杰 
国家自然科学基金资助项目(30170270,30200063)
设计合成含Arg-Gly-Asp[Arg(R)-精氨酸,Gly(G)-甘氨酸,Asp(D)-天冬氨酸]的非病毒基因载体的肽(K16-GRGDSPC)(K-赖氨酸,S-丝氨酸,P-脯氨酸,C-半胱氨酸),用其作材料聚(丙交酯-co-乙交酯)-(天冬氨酸-聚乙二醇)交替预聚物[PLGA-(ASP-PEG)]...
关键词:ARG-GLY-ASP 仿生 表面修饰 组织工程 
PLGA-[ASP-PEG]三嵌段基质材料对骨髓间充质干细胞黏附增殖及诱导成骨分化的研究被引量:4
《中国骨伤》2008年第4期282-284,共3页段智霞 郑启新 郭晓东 白玉 袁泉 陈顺广 
国家自然科学基金(编号:30170270;30200063;30470483);武汉市青年科技晨光计划(编号:20045006071-10)
目的:探讨聚乳酸聚乙醇酸共聚物(poly lactic acid-co-glycolic acid,PLGA)-天冬氨酸(asparagic acid,ASP)-聚乙二醇(poly ethylene glycol,PEG)三嵌段多元共聚物上骨髓间充质干细胞(mesenchymal stem cells,MSCs)的黏附、增殖及成骨分...
关键词: 组织工程 细胞黏附 细胞增殖 
转化生长因子-β基因转染骨髓基质干细胞在多肽修饰的聚乳酸-羟基乙酸上生长情况的研究
《中华创伤骨科杂志》2008年第1期54-58,共5页李长文 郑启新 郭晓东 全大萍 赵洁 
国家自然科学基金项目(30170270,30200063,30470483)
目的探讨转转化生长因子-β(TGF-β)基因的骨髓基质干细胞(BMSCs)在RGD多肽表面修饰的聚乳酸-羟基乙酸(PLGA)材料上的增殖、黏附、分化情况,以研究TGF-β基因和RGD多肽在调控种子细胞生物学行为方面的作用。方法将GRGDSPC多肽共...
关键词:组织工程  修饰 TGFΒ 骨髓细胞 
Experimental Research on Ectopic Osteogenesis of BMP2-derived Peptide P24 Combined with PLGA Copolymers被引量:4
《Journal of Huazhong University of Science and Technology(Medical Sciences)》2007年第2期179-182,共4页段智霞 郑启新 郭晓东 袁泉 陈顺广 
This project was supported by grants from the National Natural Sciences Foundation of China (Nos. 30470483,30200063, 30170270);a grant from Chengguang Program for Young Scientists of Wuhan Municipal Government (No. 2004500607110)
To experimentally evaluate the ectopic osteogenetic capacity of synthesized BMP2-derived peptide P24 combined with poly lactic-co-glycolic acid (PLGA), Wistar rats were divided into two groups: group A, in which BM...
关键词:BMP2-derived peptide P24 PLGA ectopic osteogenesis 
Biocompatibility of Tri-block Bone-matrix Material in vitro
《Journal of Wuhan University of Technology(Materials Science)》2007年第2期284-287,共4页段德宇 
the National Natural Science Foundation of China(No.30200063,30470483,30170270);the Excellent Youth Foundation of Wuhan Science and Technology Committee(No. 20045006071-10)
To evaluate the biocompatibility of poly(lactic acid/glycolic acid/ asparagic acid-copolyethylene glycol)(PLGA-[ASP-PEG]) tri-block copolymer in vitro, L929 fibroblast was co-cultured with the copolymer for cytoto...
关键词:tissue engineering biomaterial polylactic acid(PLA) BIOCOMPATIBILITY 
转化生长因子β1基因修饰成骨细胞复合仿生基质材料治疗骨缺损(英文)
《中国临床康复》2006年第29期167-169,i0006,共4页段德宇 郑启新 邵增务 王洪 刘勇 
国家自然科学基金资助项目(30170270)~~
背景:通过分子生物学技术与组织工程技术相结合以修复骨缺损,是骨科当前重要的研究方向之一。转化生长因子β1作为重要的骨形成因子,在骨代谢和骨损伤修复中发挥着极为重要的作用。目的:观察转化生长因子β1基因修饰的成骨细胞复合仿生...
关键词:转化生长因子Β 转染 成骨细胞 创伤和损伤 仿生材料 
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