云南高校图书馆联盟文献共享服务平台- 国家重点基础研究发展计划(2014CB931900)

国家重点基础研究发展计划(2014CB931900): 作品数：15被引量：46H指数：4; 导出分析报告; 相关作者：张驰李晓毅王雅丽史祎诗李登宇更多>>; 相关机构：中国科学院大学更多>>; 相关期刊：《Science China(Life Sciences)》《Acta Pharmacologica Sinica》《Science China Chemistry》《Chinese Journal of Polymer Science》更多>>; 相关主题：POLYLYSINEDNACEOMNO2ENHANCED更多>>; 相关领域：医药卫生化学工程理学生物学更多>>

TRAIL-based gene delivery and therapeutic strategies被引量：7: 《Acta Pharmacologica Sinica》2019年第11期1373-1385,共13页Hui-hai Zhong Hui-yuan Wang Jian Li Yong-zhuo Huang; TRAIL(tumor necrosis factor-re I a ted apoptosis-inducing ligand),also known as AP02L,belongs to the tumor necrosis factor family.By binding to the death receptor 4(DR4)or DR5,TRAIL induces apoptosis of tumor cells wi...; 关键词：TRAIL GENE delivery GENE THERAPY DNA DRUG delivery systems NON-VIRAL VECTORS cancer THERAPY

DNA对纳米CeO_2线类氧化酶活性的影响: 《中国科学院大学学报（中英文）》2019年第2期275-279,共5页杨丁丁姚鑫; 国家自然科学基金(21271184);973项目(2014CB931900);中国科学院科学仪器发展项目(ZDKYYQ20170001)资助; 采用水热法合成纳米CeO_2线,使用透射电子显微镜、X射线衍射仪和拉曼光谱仪对其进行表征。使用傅里叶变换红外光谱仪和紫外可见分光光度计对DNA与纳米CeO_2线的相互作用进行分析,然后采用紫外可见分光光度法研究DNA对纳米CeO_2线类氧化...; 关键词：纳米CeO2线 DNA 紫外可见分光光度法类氧化酶活性抑制作用

两种不同纳米金修饰方法制备的Au/CeO_2复合物的抗氧化性能: 《中国科学院大学学报（中英文）》2019年第1期131-136,共6页法孟梅姚鑫; 国家自然科学基金(21271184);973项目(2014CB931900);中国科学院科学仪器发展项目(ZDKYYQ20170001)资助; 以水热法制备的CeO_2纳米棒为载体,分别采用溶胶法和沉积法对其进行纳米金修饰,得到两种不同纳米金修饰方法制备的Au/CeO_2复合物。在MV-Fenton体系中用紫外分光光度法对两种Au/CeO_2复合物的抗氧化性能进行研究。结果表明:溶胶法制备的...; 关键词：Au/CeO2复合物溶胶法沉积法抗氧化性能表面结构

超支化聚缩水甘油醚负载盐酸阿霉素纳米粒子的性能被引量：1: 《中国科学院大学学报（中英文）》2018年第4期481-486,共6页法孟梅刘旭王蔼廉张辽云姚鑫; 天然药物及仿生药物国家重点实验室开放基金(20120207);国家自然科学基金(21271184);973项目(2014CB931900);中国科学院"战略优先研究项目"(XDA 09030301)资助; 以缩水甘油为单体,采用阴离子聚合法一步合成分子量为5 000的超支化聚缩水甘油醚(HPG),将其作为药物载体负载盐酸阿霉素(DOX)。向载体中投入不同量的DOX,用扫描电子显微镜对载药纳米粒子进行表征,用荧光标准曲线测定法研究HPG对DOX的负...; 关键词：超支化聚缩水甘油醚药物载体阿霉素负载及释放纳米粒子

DNA与B-PDEAEA自组装过程的分子动力学模拟: 《中国科学院大学学报（中英文）》2018年第4期487-491,共5页黄须啟李晓毅; 国家自然科学基金(21274164);973项目(2014CB931900)资助; 通过分子动力学模拟,研究DNA/B-PDEAEA纳米颗粒的自组装过程。模拟结果表明,在自组装过程中静电相互作用是主要驱动力;在相同氮磷比的条件下,随着DNA碱基对数目的增加,更易于形成稳定的纳米颗粒。在相同碱基对数目的条件下,随着氮磷比...; 关键词：DNA 自组装分子动力学模拟

Synthesis and evaluation of a paclitaxel-binding polymeric micelle for efficient breast cancer therapy被引量：6: 《Science China(Life Sciences)》2018年第4期436-447,共12页Jiajia Xiang Bihan Wu Zhuxian Zhou Shiqi Hu Ying Piao Quan Zhou Guowei Wang Jianbin Tang Xiangrui Liu Youqing Shen; supported by the National Natural Science Foundation of China (U1501243, 51603181);the National Basic Research Program (2014CB931900);the National Natural Science Foundation of China (51603181);the Fundamental Research Funds for the Central Universities (2016QNA4024) for financial support; Paclitaxel(PTX) is one of the most effective anticancer drugs for the treatment of various solid tumors, but its clinical use is limited by its poor solubility, low bioavailability, and severe systemic toxicity. Encap...; 关键词：paclitaxel delivery paclitaxel-binding phenethyl isothiocyanate dendritic polylysine polymeric micelles cancer drugdelivery enhanced stability prolonged blood circulation

Ultra-low charge transfer resistance carbons by onepot hydrothermal method for glucose sensing: 《Science China Materials》2017年第12期1234-1244,共11页胡博韬刘仁材陈靖容赵湛张淑真康沛伦; supported by the National Basic Research Program of China (973 Program,2014CB931900);UCAS Young Teacher Research Fund (Y55103NY00,Y55103EY00,and Y25102TN00);Beijing Natural Science Foundation (Z160002);The Chinese Academy of Sciences Key Project Foundation (KFZD-SW-202); Hydrothermal carbon （HTC） is typically well- dispersed, but it remains a great challenge for HTC to become conductive. Co-doping with heteroatoms has been confirmed to be an effective strategy to significantly promo...; 关键词：hydrothermal method glucose biosensor charge transfer resistance heteroatom doped carbon electrochemical behavior

Co-delivery of docetaxel and silibinin using pH-sensitive micelles improves therapy of metastatic breast cancer被引量：4: 《Acta Pharmacologica Sinica》2017年第12期1655-1662,共8页Xin-yue DONG Tian-qun LANG Qi YIN Peng-cheng ZHANG Ya-ping LI; The National Basic Research Program of China （2014CB931900）, the National Natural Science Foundation of China （81521005 81230029）, and the Youth Innovation Promotion Association of CAS （2015226） are gratefully acknowledged for financial support.; Breast cancer is the most vicious killer for women, and tumor metastasis is one of the leading causes of breast cancer therapy failure In this study, a new pH-sensitive polymer （polyethylene glycol-block-poly[（1,4-b...; 关键词：pH-sensitive polymer CO-DELIVERY MICELLE DOCETAXEL SILIBININ breast cancer mouse breast cancer cell line 4T1 metastasis

Albumin nanoreactor-templated synthesis of Gd_2O_3/CuS hybrid nanodots for cancer theranostics被引量：3: 《Science China Materials》2017年第6期554-562,共9页温茹吕小燕杨涛李誉唐永安柏欣柯亨特沈钧康陈华兵; financially supported by the National Natural Science Foundation of China (31422021, 51473109, and 81501585);National Basic Research Program of China (2014CB931900);Natural Science Foundation of Jiangsu Province of China (BK20150348);Natural Science Foundation of the Jiangsu Higher Education Institutions of China (15KJB310019);China Postdoctoral Science Foundation (2015M570475 and 2016T90496);Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD);Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-PsychoDiseases, Open Fund of CAS Key Laboratory of Nano-Bio Interface (16NBI02);Jiangsu Undergraduates Innovation and Entrepreneurship Program (20150285075Y); It remains a great challenge to explore the facile way to fabricate multi-component nanoparticles in theranostic nanomedicine. Herein, an albumin nanoreactor templated synthesis of theranostic Gd203/CuS hybrid nanodo...; 关键词：albumin nanoreactor NANODOT THERANOSTICS pho tothermal therapy magnetic resonance imaging

Core-shell Au@MnO2 nanoparticles for enhanced radiotherapy via improving the tumor oxygenation被引量：13: 《Nano Research》2016年第11期3267-3278,共12页Xuan Yi Lei Chen Xiaoyan Zhong Roulin Gao Yitao Qian Fan Wu Guosheng Song Zhifang Chai Zhuang Liu Kai Yang; This work was partially supported by the National Basic Research Program of China （973 Program, Nos. 2014CB931900 and 2012CB932600）, National Natural Science Foundation of China （Nos. 81471716 and 31400861）, the National Natural Science Foundation of Jiangsu Province （No. BK20140320）, and a Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions （PAPD）.; Local hypoxia in solid tumors often results in resistance to radiotherapy （RT）, in which oxygen is an essential element for enhancing DNA damage caused by ionizing radiation. Herein, we developed gold@manganese diox...; 关键词：enhanced radiotherapy RADIOSENSITIZER HYPOXIA high-Z element core-shell structure

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